ID A0A093PLS7_PYGAD Unreviewed; 1863 AA.
AC A0A093PLS7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=AS28_10863 {ECO:0000313|EMBL:KFW73112.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW73112.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW73112.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW73112.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL225506; KFW73112.1; -; Genomic_DNA.
DR STRING; 9238.A0A093PLS7; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14629; R-PTP-F-2; 1.
DR CDD; cd14626; R-PTPc-F-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFW73112.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1217..1240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..92
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 104..193
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 201..283
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 290..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 483..572
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 577..674
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 679..778
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 779..873
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 877..969
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 973..1057
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1308..1563
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1483..1554
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1595..1854
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1772..1845
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW73112.1"
FT NON_TER 1863
FT /evidence="ECO:0000313|EMBL:KFW73112.1"
SQ SEQUENCE 1863 AA; 208788 MW; C85B0FDF1A1A6D85 CRC64;
KPTFMKAPED QIGISGGVAS FVCQATGEPK PRITWMKKGK KVSSQRFEVI EFDDGSGSVL
RIQPLRVHRD EAIYECTATN SVGEINTSAK LTVLEEDHLP AGFPTIDMGP QLKVVEKART
ATMLCAASGN PDPEISWFKD FLPVDTATSN GRIKQLRSGA LQIENSEESD QGKYECVATN
SAGTRYSAPA NLYVRVRRVA PRFSIPPSNH EVMPGGSVNL TCVAVGAPMP YVKWMAGVEE
LTKEDEMPVG RNVLELNNIM QSANYTCVAI SSLGMIEATA QITVKALPKP PTEPLVTETT
ATSVTLTWDS GNSDPISYYV IQYKPKSLEG QFQEVDGVAT TRYSIGGLSP FSEYEFRVIA
VNNIGRGPPS ELVEARTGEQ APSSPPLKVQ ARMLSASTML VQWEQPEEPN GQIRGYRVYY
TTDPHLPLSM WQKHNTDDSH LTTVGSLITG TTYSIRVLAF TSVGDGPPSD IIQVKTQQGV
PAQPADFQAE AESDTRILLT WLPASQERIT KYELLYWEGE DGTQQKVEFD PTSSYAVEGL
KPDTLYKFRL GARSELGVGV YTPMIEARTA QSTPSAPPQE VECVSTSSTT IRVSWVPPPA
QSRNGVITQY SIAYQAVEGD DNTKHVVDGI GREHSSWEIK DLEKWTEYKV WVRAHTDVGP
GPESIPVHVR TDEDVPSAPP RKVEVESVNS TAIRVSWKLP ISNKQHGQIR GYQVTYVKLE
NNEPRGQPVI KDVMLSEAQE TVIGGLLPET TYSVTVAAYT TKGDGARSKP KVITTTGAVP
GKPTMMISTT AMNTALIQWH PPKEMVGELL GYRLQYRRLD EEKINTIDFG KRDHHYTVTN
LHKGATYLFK LSAKNRAGPG EEFEKEITTA EDVPSGFPQN LRVVGLTTST TEVAWDPPVL
AERNGKIVNY TVVYRDINSQ QDLVNITKDT SITLMNLKPD TTYDIKVRAR TNKGVGPLSP
SIQSRTMPVE QVFAKNFRVN AVMKTSVLLS WEVPDSYKSA VPFKILYNSQ SVEVDGHSMK
KLISDLQPDT DYSFVLMNRG SSAGGLQHLV SIRTAPDVLQ SKPIATNKYI QEGKFTLTLP
KVQTTVPVRW YYIVVVPADQ STSSPTARWR TPDEMELDQL LEAISQGSQS RRQRRQADRL
KPYIAAQMDL LPETFTLGDE KNYKGFYNKP LSQDLSYRCF VLASLEDGDT KRYAASPYSD
EIVMEVASAK QQDEPEMLWV MGPVLAVILI IIIVIAILLF KRKRAHSPSS KDEHSIGLKD
SLLAHSSDPV EMRRLNYQTP GMRDHPPIPV TDLADNIDRL KANDGLKFSQ EYESIDPGQQ
FTWENSNLEV NKPKNRYANV IAYDHSRVIL TSIDGVPGSD YINANYIDGY RKQNAYIATQ
GPLPETLSDF WRMVWEQRTA TIVMMTRLEE KSRVKCDQYW PSRGTETYGM IQVTLLDTVE
LATYTVRTFA LYKNGSSEKR ELRQFQFMAW PDHGVPEYPT PILAFLRRVK ACNPPDAGPM
VVHCSAGVGR TGCFIVIDAM LERMKHEKTV DIYGHVTCMR SQRNYMVQTE DQYIFIHEAL
LEAATCGNTE VPARNLFAHI QKLTQVPPGE SVTAMELEFK LLANSKAHTS RFISANLPCN
KFKNRLVNIM PYELTRVCLQ PIRGVEGSDY INASFIDGYR QQKAYIATQG PLAETTEDFW
RMLWEHNSTI VVMLTKLREM GREKCHQYWP AERSARYQYF VVDPMAEYNM PQYILREFKV
TDARDGQSRT IRQFQFTDWP EQGVPKTGEG FIDFIGQVHK TKEQFGQDGP ITVHCSAGVG
RTGVFITLSI VLERMRYEGV VDMFQTVKTL RTQRPAMVQT EDQYQLCYRA ALEYLGSFDH
YAT
//