ID A0A093PM48_9PASS Unreviewed; 1244 AA.
AC A0A093PM48;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|ARBA:ARBA00032044, ECO:0000256|RuleBase:RU365061};
DE Flags: Fragment;
GN ORFNames=N305_03396 {ECO:0000313|EMBL:KFW77511.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW77511.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW77511.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW77511.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
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DR EMBL; KL669997; KFW77511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093PM48; -.
DR STRING; 328815.ENSMVIP00005004281; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR PRINTS; PR01365; TELOMERASERT.
DR SMART; SM00975; Telomerase_RBD; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:KFW77511.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 712..1047
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW77511.1"
FT NON_TER 1244
FT /evidence="ECO:0000313|EMBL:KFW77511.1"
SQ SEQUENCE 1244 AA; 143619 MW; 7EFE93557F63C632 CRC64;
FLQLSSQNEV ITRVVQRLCE KGKKNVLAYG YSLVDENSSP FQIIPLSNIC SYLSNTSTET
LRISGLWETL LSRIGDDVMM YLLEHCAIFM LVPPSNCYQV CGQPIYELIS QNVDSFPVFV
KQRVSKHKCN SLLDYVQKRL SFHRKYLSKS HRWQCRQRLE DNVSSMGNKK NSNIRSLVSS
YQYSAKDVSK ASKQIRVVTE HLEKTNSYSL CLSSTAPSLK RKLHREQLEI PAKRAKVEEK
VRDEKACKLT PHVNQSSSKR YETGYVASHP ESLIKNNHIS QRSNSAMSGP SLVHTSHDRK
KFVAGESFLL QGVQSNKPLK SSIEMQAESH RKGVEMHMCE PQVNSVQIKP VEGNSSKCRK
QESPLHNLAK KLPNRLLRSA VYIDRKSLLY SQRSFQECFP KSFSLNRLQG CQAGGRRLIE
TIFLSRNLLE QRRNQSLPHR RWRKKRLPKR YWQMRPIFQK LLKNHGKCPY LALLKKNCPV
RISESGRKTN LPRQAEVREP AEQFGKEPTK CVTSSKCESG HSVVSGNLRA PLAKSVCGEL
QSEKQNPGEV CDSALRELLK QHSSHWQVYM FVRECMEHVI PAELWGSNHN KCRFLKNVKA
FISRGKFAKL SLQELMWKMR VNDCMWLRLG KGDHFVPADE HCFREELLAK FLYWLMDTYV
VGLLRSFFYI TETMFQKNML FYYRKFIWGK LQNIGIRNHF ARVRLRPLSS KEMEAVRQKK
FVLMASKLRF IPKLNGLRPI VKVKGVVEAQ AFSRESREKK MHHYNTQLKN LFSVLNYERT
INTSFLGSSV FGKDDIYKTW KQFVMKVLES GGEIPHFYCV KADVSRAYDS IPHDKLVEVI
SRILKPEKRT VYCIRRYAVI MITTSGKARR LYRRHVSTFK DFKPDMKHFV SHLQETTSLQ
NAIVVEQSLT FNETSTSMFN FFLQTIHNNI LEIGNRYYLQ CCGIPQGSIL STLLCSLCYG
DMENKLLCGV QQDGVLIRLI DDFLLVTPHL SQARTFLRTL AAGIPEYGFL INPNKTVVNF
PVDDIPGCPK FKQLPDCRLI PWCGLLLDIQ TLEVYCDYSS YSYTSIRSSL SFNSSRTAGK
NMKHKLIAVL KLKCHCLFLD LQINSLRTVL INIYKIFLLQ AYRFHACVLQ LPFNQQVRKN
PYFFLRIISE TASCCYGILK AKNAGIALDN KGASDMFPSE AAEWLCYHAF IVKLSNHKVV
YKCLLTPLKI CKMQLFRKIS KDTMALLKTV TEPSLCQDFK TILD
//
