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Database: UniProt
Entry: A0A093PNE3_PHACA
LinkDB: A0A093PNE3_PHACA
Original site: A0A093PNE3_PHACA 
ID   A0A093PNE3_PHACA        Unreviewed;      1164 AA.
AC   A0A093PNE3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE            Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE            EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
DE   Flags: Fragment;
GN   ORFNames=N336_05678 {ECO:0000313|EMBL:KFW75770.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW75770.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW75770.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW75770.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-
CC         octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00023371};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328;
CC         Evidence={ECO:0000256|ARBA:ARBA00023371};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC         phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:456216; EC=2.7.1.107;
CC         Evidence={ECO:0000256|RuleBase:RU361128};
CC   -!- PATHWAY: Lipid metabolism; glycerolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00005175}.
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC       {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}.
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DR   EMBL; KL413555; KFW75770.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093PNE3; -.
DR   UniPathway; UPA00230; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd20847; C1_DGKdelta_rpt1; 1.
DR   CDD; cd20893; C1_DGKdelta_rpt2; 1.
DR   CDD; cd13274; PH_DGK_type2; 1.
DR   CDD; cd09575; SAM_DGK-delta; 1.
DR   Gene3D; 2.60.200.40; -; 1.
DR   Gene3D; 3.30.60.20; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR047478; C1_DGKdelta_rpt1.
DR   InterPro; IPR047477; C1_DGKdelta_rpt2.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR037606; DGK-delta_SAM.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR   PANTHER; PTHR11255:SF30; DIACYLGLYCEROL KINASE DELTA; 1.
DR   Pfam; PF00130; C1_1; 2.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50146; DAGK; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361128};
KW   Kinase {ECO:0000256|RuleBase:RU361128, ECO:0000313|EMBL:KFW75770.1};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|RuleBase:RU361128};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          1..94
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          111..161
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          183..234
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          265..400
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   DOMAIN          1095..1158
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          502..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW75770.1"
FT   NON_TER         1164
FT                   /evidence="ECO:0000313|EMBL:KFW75770.1"
SQ   SEQUENCE   1164 AA;  130205 MW;  A5A6FA518D424BB3 CRC64;
     TIIKEGMLMK QTSSFQRWKR RYFKLRGRTL YYAKTAKSII FDEVDLTDAS VAESSTKNVN
     NSFTVITPCR KLILCADNRK EMEDWIAALK TVQNREHFES TQYSMDHFSG MHNWYACSHA
     RPTYCNVCRE ALSGVTSHGL SCEVCKFKAH KRCAVRATNN CKWTTLASIG KDIIEDEDGI
     SMPHQWLEGN LPVSAKCTVC DKTCGSVLRL QDWRCLWCKA MVHTACKELL PNKCPLGLCK
     VSVIPPTALN SIDSDGFWKA TCPPSCTSPL LVFVNSKSGD NQGVKFLRRF KQLLNPAQVF
     DLMNGGPHLG LRLFQKFDTF RILVCGGDGS VGWVLSEIDS LNLHKQCQLG VLPLGTGNDL
     ARVLGWGSAC DDDTQLPQIL EKLERASTKM LDRWSIMVYE TKLPRQASTS TVTEDFSEDS
     EKILFYEDSV AAHLSKILTS DQHSVVISSA KVLCETVKDF VARVGKAYEK ATESSEESEV
     MARKCSVLKE KLDSLLKTLN DESQASSCLP NPPPTIAEET EDGDGSGSAC DSSSDRSVGS
     SCTARPQIFR PREQLMLRAN SLKKAIRQII EHAEKAVDEQ NAQTQEQEGF LLSLSASEEG
     KELRNEDKIS LQSSHSSSYG VSKGRSQRKV SKSPCERLIS KGSLSLGSSA SLPPQTGNRD
     NLPMLNTKIL YPNIRAGMSG SLPGSSVISR LLIHADPFNS EPENLECYTE KCVMNNYFGI
     GLDAKISLDF NNKRDEHPEK CRSRTKNMMW YGVLGTKELL HRTYKNLEQK VLLECDGRPI
     PLPSLQGIAV LNIPSYAGGT NFWGGTKEDD TFTAPSFDDK ILEVVAVFGS MQMAVSRVIN
     LQHHRIAQCR TVKIAILGEE GVPVQVDGEA WIQPPGYIWI VHKNRAQTLT RDRAFESTLK
     SWEDKQKCEL SRPSSFSLQP EIMSEEESTQ INQFGQAAGA LIHSIREIAQ SYQDMEQELA
     HAVNASSKSM DKVYAKSKST EGLNCSLVVE MVNNVKALHN ETELLLAGKM ALQLDPPQKE
     QLQAALADMD LQLRKLADIP WLWQLMEPCD EENQMLDYSK RSRSGKFRLV TKFKKEKNNK
     NKETHSSMGL PVHLWGTEEV AAWLEHLSLC EYKDIFIRHD VRGSELLHLE RRDLKDLGVT
     KVGHMKRILH GIKELSRSTP ANEV
//
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