ID   A0A093PNR1_9PASS        Unreviewed;       165 AA.
AC   A0A093PNR1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
DE   Flags: Fragment;
GN   ORFNames=N305_09763 {ECO:0000313|EMBL:KFW75895.1};
OS   Manacus vitellinus (golden-collared manakin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX   NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW75895.1, ECO:0000313|Proteomes:UP000053258};
RN   [1] {ECO:0000313|EMBL:KFW75895.1, ECO:0000313|Proteomes:UP000053258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW75895.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC       leukemic cells. Its activities include the induction of hematopoietic
CC       differentiation in normal and myeloid leukemia cells, the induction of
CC       neuronal cell differentiation, and the stimulation of acute-phase
CC       protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; KL669224; KFW75895.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093PNR1; -.
DR   STRING; 328815.ENSMVIP00005009106; -.
DR   Proteomes; UP000053258; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003624; Leukemia_IF.
DR   InterPro; IPR001581; Leukemia_IF/oncostatin.
DR   PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR   PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR   Pfam; PF01291; LIF_OSM; 1.
DR   PRINTS; PR01883; LEUKAEMIAIF.
DR   SMART; SM00080; LIF_OSM; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053258}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW75895.1"
FT   NON_TER         165
FT                   /evidence="ECO:0000313|EMBL:KFW75895.1"
SQ   SEQUENCE   165 AA;  18739 MW;  0F2734B4526203DA CRC64;
     CRSNVQEQTR RQGALLNATA QDLFSLYLKC QGEPFSSESD KLCNPTGIFF PAFRVNRTSE
     RKEVMVAMYK LFTFLNASLG NITRDQEELN PTAKELLDRL HNTTKTTRGL ISNLTCLLCK
     NYNIFQVDVR YGESSKGKSA FKKKQQGCQV LRKYVQVIGQ AARVL
//