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Database: UniProt
Entry: A0A093PY01_9PASS
LinkDB: A0A093PY01_9PASS
Original site: A0A093PY01_9PASS 
ID   A0A093PY01_9PASS        Unreviewed;      1130 AA.
AC   A0A093PY01;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-DEC-2019, entry version 34.
DE   RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
DE            EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
DE   Flags: Fragment;
GN   ORFNames=N305_02285 {ECO:0000313|EMBL:KFW79090.1};
OS   Manacus vitellinus (golden-collared manakin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX   NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW79090.1, ECO:0000313|Proteomes:UP000053258};
RN   [1] {ECO:0000313|EMBL:KFW79090.1, ECO:0000313|Proteomes:UP000053258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW79090.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC         Evidence={ECO:0000256|RuleBase:RU362096,
CC         ECO:0000256|SAAS:SAAS01115681};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|RuleBase:RU362096}.
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DR   EMBL; KL670487; KFW79090.1; -; Genomic_DNA.
DR   Proteomes; UP000053258; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042393; F:histone binding; IEA:InterPro.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13333; FERM_C_JAK2; 1.
DR   CDD; cd05078; PTK_Jak2_rpt1; 1.
DR   CDD; cd14205; PTKc_Jak2_rpt2; 1.
DR   CDD; cd10379; SH2_Jak2; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR041155; FERM_F1.
DR   InterPro; IPR041046; FERM_F2.
DR   InterPro; IPR041381; Jak1_PHL_dom.
DR   InterPro; IPR037838; JAK2_FERM_C-lobe.
DR   InterPro; IPR035860; JAK2_SH2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR035588; PTK_Jak2_rpt1.
DR   InterPro; IPR035589; PTKc_Jak2_rpt2.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
DR   InterPro; IPR020693; Tyr_kinase_non-rcpt_Jak2.
DR   Pfam; PF18379; FERM_F1; 1.
DR   Pfam; PF18377; FERM_F2; 1.
DR   Pfam; PF17887; Jak1_Phl; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 2.
DR   PIRSF; PIRSF000636; TyrPK_Jak; 1.
DR   PRINTS; PR01823; JANUSKINASE.
DR   PRINTS; PR01825; JANUSKINASE2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00219; TyrKc; 2.
DR   SUPFAM; SSF47031; SSF47031; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000636-2,
KW   ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00990534};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00987901,
KW   ECO:0000313|EMBL:KFW79090.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000636-2,
KW   ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00987259};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Transferase {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00989498};
KW   Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096,
KW   ECO:0000256|SAAS:SAAS00897698}.
FT   DOMAIN          36..378
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          399..480
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          543..807
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          847..1126
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   NP_BIND         853..861
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT   COILED          340..360
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   ACT_SITE        974
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
FT   BINDING         880
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000636-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW79090.1"
FT   NON_TER         1130
FT                   /evidence="ECO:0000313|EMBL:KFW79090.1"
SQ   SEQUENCE   1130 AA;  130020 MW;  C2A87F51AEF81307 CRC64;
     TMACLTMTDM ESTATASVHQ NGDIHGNTSA PRQTEPLLQV YLYHSPGKTG EDYLQFPAGE
     YVAEELCAVA CKACGIMPVY HNMFALMSET DRMWYPPNHT FHVDEATRLK LIYRIRFYFP
     HWYCSGTNRA YRYGILRGAE SPVLDDLVMS YLFAQWRADF LEGWVQMPVT HETQEECLGM
     AVLDMMRVAK EKDETPLAIY NSVSYKTFLP KCVRAKIQDY HILTRKRIRY RFRKFIQQFG
     QCKATARNLK LKYLINLETL QSAFYSEVFE VKEPGGGPGE ESFATIVITG NGGIQCSRGK
     LKDCETLAEQ DLQTYCDFPD IIDVSIKQAS QEGSSERRIV TIHKQDSKNL EAEFQSLREA
     LSFVSLIDGY YRLTADAHHY LCKEVAPPSV LENIQSNCHG PIFMDFAISK LKKAGNQTGF
     YVLRCSPKDF KKYFLTFAIE RDNTTDYKHC LITKNENGEY NLSGTKRSFS NLKDLLTCYQ
     TETVRSDSII FQFIKCCPPK PKDKSNLLVF RSNSVSDVPS SPTLQRHNNV NQMVFHKIRN
     EDLIFEESLG QGTFTKIFKG VRKEVGDYGQ LHQTEVLLKV LDKVHRNYSE SFFEAASMMS
     QLSYKHLVLN YGVCVCGEEN ILVQEYVKFG SLDTYLKKNK NIINILWKLE VAKQLALAMH
     FLEDKGLVHG NVCAKNILLI REEDRKSGSL PFIKLSDPGI SITVLPRDIL LERIPWVPPE
     CIENPKQLSL ATDKWSFGTT LWEICSGGDK PLSALDSSRK LQFYEDRHQL PAPNWTELAN
     LINNCMDYEP DFRPSFRAII RDLNSLFTPD YELLTESDML PNMRIGALGF SGAFEDRDPT
     QFEERHLKFL QQLGKGNFGS VEMCRYDPLQ DNTGEVVAVK KLQHSTEEHL RDFEREIEIL
     KSLQHDNIVK YKGVCYSAGR RNLRLIMEYL PYGSLRDYLQ KHKERLDHKK LLLYASQICK
     GMEYLGTKRY VHRDLATRNI LVENENRVKI GDFGLTKVLP QDKEYYKVKE PGESPIFWYA
     PESLTESKFS VASDVWSFGV VLYELFTYID KSKSPPAEFM RMIGNDKQGQ MIVFHLIELL
     KNNGRLPRPD GCPDEIYAIM KECWNNNVAQ RPTFRDLAQR VDHIRENMGG
//
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