ID A0A093Q060_9PASS Unreviewed; 559 AA.
AC A0A093Q060;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Complement component C8 alpha chain {ECO:0000313|EMBL:KFW82041.1};
DE Flags: Fragment;
GN ORFNames=N305_06904 {ECO:0000313|EMBL:KFW82041.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW82041.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW82041.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW82041.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KL671386; KFW82041.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Q060; -.
DR STRING; 328815.ENSMVIP00005011866; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 110..473
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 526..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 71..83
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 90..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW82041.1"
FT NON_TER 559
FT /evidence="ECO:0000313|EMBL:KFW82041.1"
SQ SEQUENCE 559 AA; 63056 MW; 649BD540A72964B4 CRC64;
RSSRDVNSPA PVDCQLSQWS GWTDCFPCQE KKHRYRRLVQ PAKFAGRRCA GHLWDEQTCH
AETTCTEPPS CGKDFRCEET GRCIKRHLVC NGERDCRDGS DEENCEDEDT ESPCKDLFPI
PGSIKAVQGY NILTQEERQF VYDPEFFGGQ CEYVYNGEWR ELKYDAACER LYYGDDEKYF
RKPYNFHIYQ FLAHADSGFT FEFYDDSKDL LDALKNHKSK TMGFTIGIGP AGSDILVNLG
LTLSGAKGSL KNFTEYTAKD LAFIRAVTKV QTARFKMRRD NIVLHEDVLL SLQELPDTYN
YGMYAKFIND YGTHFMTSGT MGGIFEYILV INKEEMRRKA VTGEEIGACI GLSLGLTASE
NKLDLNASVS YSDCQKKGFL KTGRESHSAV VEDIIPRIRG GDTSYSGGLL NSWDGNMYRH
WGRSLKYNPA VIDFELQPIH EILRRSNLGD METKRQNLKR ALDEYLLEFN ACRCGPCQNN
GEPILVGDTC SCQCNAGSRG PACEQTERRG GVTDGRWSCW SGWSPCQAGT SRRSRQCTNP
APQNGGQPCT GRPLQSRAC
//
