ID A0A093Q5F8_9PASS Unreviewed; 582 AA.
AC A0A093Q5F8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
DE Flags: Fragment;
GN ORFNames=N305_10081 {ECO:0000313|EMBL:KFW84193.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW84193.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW84193.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW84193.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; KL672030; KFW84193.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Q5F8; -.
DR STRING; 328815.ENSMVIP00005023509; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:KFW84193.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 212..407
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 428..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW84193.1"
FT NON_TER 582
FT /evidence="ECO:0000313|EMBL:KFW84193.1"
SQ SEQUENCE 582 AA; 63880 MW; AAC98E24C8ADBE71 CRC64;
LVSISVRGSE GLYMVNGPPS FTESSAFQRD SGKNCKAVTF SKDGSLFAWC NGEKVNVVNV
TRAELLRSFD LPKAVCLEFS PKNNVLATWQ AYATGKDGTA GVANLQLHDL RTGKCLKSFI
QKKMQNWCPC WADDESICAR NVNNEVHFFE NNNFNTIANK LHLQKVSDFV LSPGAQPTKV
AVYVPGSKGA PSFVRLYQYP NFGGPQSALA NKSFFKADRV TMLWNKKATA VLVVASTEVD
KTGASYYGEQ TLHYIAANGE SAVVQLPKNG PIYDVAWSPN SLEFCAVYGF MPAKATIFNL
KCDPVFDFGT GPRNAAYYSP HGHILVLAGF GNLRGQMEVW DVKNYKLISK PVASDSTYFA
WCPDGEHIVT ATCAPRLRVG NGYKVWHYTG SVLHTYEVPS NEEMWQVSWQ PFPDGVFPER
AVRYQAVPSE VPGAEPKPAQ AYRPPALRNK PVTSSKLHED EPPQNMKPPL GGGDKPLSKT
ALKNQRKHEA KKAAKQEAKA DANQGPAQAP AAQNAPRNAV PATTTGDPEV DKKIKNLKKK
LKAIEQLKEQ AAAGKQLEKN QVEKIQKEAA LLKELEDLEL GV
//
