ID A0A093Q6S3_9PASS Unreviewed; 778 AA.
AC A0A093Q6S3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 {ECO:0000313|EMBL:KFW84301.1};
DE Flags: Fragment;
GN ORFNames=N305_11638 {ECO:0000313|EMBL:KFW84301.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW84301.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW84301.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW84301.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; KL672038; KFW84301.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093Q6S3; -.
DR STRING; 328815.ENSMVIP00005022980; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 79..138
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 166..346
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 368..473
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 478..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 726..767
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 478..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW84301.1"
FT NON_TER 778
FT /evidence="ECO:0000313|EMBL:KFW84301.1"
SQ SEQUENCE 778 AA; 87988 MW; E3B648945D51E98A CRC64;
TFDANDLYQG QNFSKVLSSL VALNKVTADI GLGSDSVCAR PSSHRIKSFD SLGSQSLHSR
TSKLFQGQYR SLDMTDNGNH QLVVRAKFNF QQTNEDELSF SKGDIIHVTR VEEGGWWEGT
LNGKTGWFPS NYVREIKSNE KPVSPKSGTL KSPPKGFDTS AINKSYYNVV LQNILETENE
YAKELQTMLS NYLRPLQASE KLTLANTSYL MGNLEEISSF QQMLVQSLEE CTKLPEAQQR
VGGCFLNLMP QMKSLYLTYC ANHPSAVNVL TEHSEELGEF MEMKGANSPG ILVLTTGLSK
PFMRLDKYPT LLKELERHME DYHPDRPDIQ KSMTAFKNLS AQCQEVRKRK ELELQILTEA
IRCWEGEDIK TLGNVIYMSQ VMIQCAGSEE KNERYLLLFP NILLMLSASP RMSGFIYQGK
LPMTGMTITK LEDSENHKNA FEISGNMIER ILVSCNNQQD LHEWVDHLQR QTKVTTVGNP
TIKPHSVPSH TLPSHPVTPS SKHSDSKPIP LTPAYHTLPH PSHHGTPHTT INWGPLEPPK
TPKPWSLSCL RPAPPLRPSA ALCYKEDLSK SPKTMKKLLP KRKPERKPSD EEFALRKSTA
ALEEDAQILK VIEAYCTSAK TRQTLNSTWQ GTDLMHNHVL ADDDQSSLDS LGRRSSLSRL
EPSDLSEDSD YDSIWTAHSY RMGSTSRSCK ESAPQVLLPE EEKIIVEETK SNGQTVIEEK
SLVDTVYALK DEVQELRQDN KKMKKSLEEE QRARKDLEKL VRKVLKNMND PSWDETNL
//
