ID A0A093QIL6_9PASS Unreviewed; 1024 AA.
AC A0A093QIL6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0000313|EMBL:KFW86210.1};
DE Flags: Fragment;
GN ORFNames=N305_13015 {ECO:0000313|EMBL:KFW86210.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW86210.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW86210.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW86210.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL672547; KFW86210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093QIL6; -.
DR STRING; 328815.ENSMVIP00005020806; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258}.
FT DOMAIN 39..317
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 521..712
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 741..838
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 915..1012
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 851..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 623..653
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 864..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW86210.1"
FT NON_TER 1024
FT /evidence="ECO:0000313|EMBL:KFW86210.1"
SQ SEQUENCE 1024 AA; 118168 MW; 524802F536AA4827 CRC64;
TPGSRLGAQK TAGVSTLESG QNLSAAMASS PARAHERDLP VRIRMLDNTV EVLDIESKCY
GQTLLTEVYK HLNLIESDYF GIEFQNIQSY WIWLEPMKPV IKQVRRPKTT MLRLAVKFFP
PDPGQLQEEY TRYLFALQIK RDLAEERLTC SDNTAALLVS HLLQSEIGDF DESEDREHLK
TNQYLPNQER IEGKILEFHK KHVGQTPAES DFQVLEIARK LEMYGIRFHL ASDREGTKIN
LAVSHMGVLV FQGNTKINTF NWSKVRKLSF KRKRFLIKLH PEGPYQDTLE FLLGSRDECK
NFWKICVEYH TFFRLFDQPK PKAKAVFFTR GSSFRYSGRT QKQLVDYIKD SGMKRTPYER
RHSKVRASTR ASNADVPKQV SSAVLLVWWS GAWTNSFLSG LELKGSEFSK CMSESPRLTT
DALQQNAVSA QSSPDRYSTE AVDMNMEEEF EFEEGSLPVD HPELSSLVLK SPLGLTPAFQ
VNLNTAAQGS SPLLSPVLSD AGGARVEEDD EMKRKRYPSD KAYFIAKEIL ATERTYLKDL
EVITVWFRSA VIKENAMPEG LMTLLFSNID PIYEFHRGFL KEIEQRLSLL EGRSNAHVKG
DYQRIGDVML RNMRILKEFT SYLQKHDEVL TELEKATKRL KKLEMVYKEF ELQKVCYLPL
NTFLLKPIQR LMHYKLILGR LCKHYTAEHR DFADCRNALK EVTEMTSQLQ NSLIRLENFQ
KLTELQHDLI GIDNLTAPGR EFIREGCLYK LTKKGLQQRM FFLFSDMLLY TSKGVTGTNQ
FKIHGHLSLH GMLVEESENE WAVPHCFTIY SAQKTIVVAA STRLEMGKWM EDLNVAIEMA
KKSTEKSEML LENSVCNRSN RSSDEVSLEQ ESEDDIHSSR SSLDRQSHHR ANTTMHVCWY
RNTSVSMTDH SVAVENQLSG YLLRKFKNSN GWQKLWVVFT NFCLFFYKTH QDDYPLASLP
LLGYTVSSPV EADGIQKDYV FKLQFKSHVY FFRAESKYTF ERWMEVIKRA TSSPARSSLL
LPKE
//
