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Database: UniProt
Entry: A0A093QKY2_PHACA
LinkDB: A0A093QKY2_PHACA
Original site: A0A093QKY2_PHACA 
ID   A0A093QKY2_PHACA        Unreviewed;       683 AA.
AC   A0A093QKY2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   05-JUN-2019, entry version 23.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
DE   Flags: Fragment;
GN   ORFNames=N336_07166 {ECO:0000313|EMBL:KFW89221.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Pelecaniformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW89221.1};
RN   [1] {ECO:0000313|EMBL:KFW89221.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW89221.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01047428}.
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DR   EMBL; KL421962; KFW89221.1; -; Genomic_DNA.
DR   MEROPS; C19.073; -.
DR   GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01045286,
KW   ECO:0000313|EMBL:KFW89221.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       24     85       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      260    666       USP. {ECO:0000259|PROSITE:PS50235}.
FT   ZN_FING      24     85       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
FT   REGION      312    332       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A093QKY2}.
FT   COILED      168    202       {ECO:0000256|SAM:Coils}.
FT   NON_TER     683    683       {ECO:0000313|EMBL:KFW89221.1}.
SQ   SEQUENCE   683 AA;  78665 MW;  640D8872C0057D62 CRC64;
     MDRCKHVGRL RLAQDHSILN PQKWHCVDCQ TTESIWACLK CSHVACGRYI EEHALKHFEE
     TRHPLAMEVN DLYVFCYLCE DYVLNDNPEG DLKLLRSSLS AIKSQKHDPS TRSGRTLRSM
     ALGEDMCSHQ RSPQGQSQML TALWHRRQSL LAKALRTWFE KSSRGQLKLK EKKELEELEK
     KKEAARQRRQ EVKRQLLEEL ANTPPRKSAR LLSHVHRENL IPRKFREVAT ASPTSRQMQS
     SRFKQFYSIR RKPLMTPGVT GLRNLGNTCY MNSILQVLSH LQKFRECFLT LDLCETEELL
     AKTVNGKSRM PGKLANGSAA NESGKTDKVG SYGTQSLPAG LNGGSSISRS LELIQPKEPS
     SKHISLCHEL HTLFRVMWSG KWALVSPFAM LHSVWSLIPA FRGYDQQDAQ EFLCELLDKV
     QQELESEGTK RRILIPFSQR KLTKQVLKVV NTIFHGQLLS QVTCITCNYK SNTVEPFWDL
     SLEFPERYHS IEKGIIPVNQ TECMLTEMLA KFTETEALEG RIYACDQCNS KRRKSSPKPL
     VLSEAKKQLM IYRLPQVLRL HLKRFRWSER NHREKIGVHV LFDQVLNMEP YCCRDSLSSL
     DKETFVYDLS AVVMHHGKGF GSGHYTAYCY NTEGGFWVHC NDSKLNVCSV EEVCKTQAYI
     LFYTQRTVQD KARISEKQLQ AQV
//
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