ID A0A093R097_PYGAD Unreviewed; 856 AA.
AC A0A093R097;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Low-density lipoprotein receptor-related protein 8 {ECO:0000313|EMBL:KFW64449.1};
DE Flags: Fragment;
GN ORFNames=AS28_09463 {ECO:0000313|EMBL:KFW64449.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW64449.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW64449.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW64449.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KL224816; KFW64449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093R097; -.
DR STRING; 9238.A0A093R097; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KFW64449.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFW64449.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 775..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 412..458
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 459..501
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 502..545
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 546..590
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 4..16
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 11..29
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 66..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 85..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 92..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 104..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 124..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 131..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 170..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 189..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 209..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 216..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 228..243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 257..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 331..341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW64449.1"
FT NON_TER 856
FT /evidence="ECO:0000313|EMBL:KFW64449.1"
SQ SEQUENCE 856 AA; 94676 MW; FC67F34174D65767 CRC64;
KKTCAESDFT CDNGHCIPAR WKCDGEEECP DGSDESEAAC TKQVCPAEKI SCGDLSNKCI
PSSWRCDGQK DCESGIDEAG CTPACSPNEF QCSNKSCISM IFVCDGDNDC GDGSDERKCS
PLTCNPNEFQ CNNSVCIPEL WVCDNQPDCE DQSDESIEKC GYDAKALNTC AAHEFQCSNG
ECIHLNWKCD GDEDCKDKSD EQDCPLVTCQ PDEFQCGDGT CIHGAKQCDK VHDCPDNSDE
AGCVQESACE SPSKFQCKSG ECIDGGKVCD SHRDCRDWSD EPLKECGINE CSMNNGGCSH
ICKDLKIGYE CECPLGYKLL DKKTCGDIDE CENPDACSQI CINYKGDYKC ECYEGYEMDT
LSKNCKAVGK SPYLIFTNRH EVRKIDLVKR DYSRIIPMLK NVVALDVEVS TNRIYWCDLF
YRKIYSAYID KASDTAEQVI LIDSQLNSPE GLAIDWVHKN IYWTDSGNKT ISVATADGSR
RRTLFNSDLS EPRAIAVDPT RRFMYWSDWG DKAKIEKAGL NGVGRQVLVT DNIEWPNGIT
LDLLNQRLYW VDSKLHSLSC IDFNGSNRKV LISSVDDLSH PFGLAVFEDR VFWTDLENEA
IFSANRLNGL DISILAENLN NPHDIVVFHE LKQPKAPDSC ELSPQPNGGC EYLCLPAPQI
SPHSPKYTCA CPDNMWLGPD MKKCYKDLPT TSTTVLVSTT TASRTASTTT IATVIGSANN
TTEVVPKPVS EATITTPSFP LPSTTSILID SEMTTGNSNL SQHYANNDQG FDSTVTAAVI
GIVIPVVVIG LLCMGGYLIW RNWKRKNTKS MNFDNPVYRK TTEEEDEDEI HIGRTAQIGH
VYPARVALSL EDDGLP
//
