ID A0A093R2J0_PYGAD Unreviewed; 1425 AA.
AC A0A093R2J0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 6 {ECO:0000313|EMBL:KFW65239.1};
DE Flags: Fragment;
GN ORFNames=AS28_05593 {ECO:0000313|EMBL:KFW65239.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW65239.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW65239.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW65239.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KL224878; KFW65239.1; -; Genomic_DNA.
DR STRING; 9238.A0A093R2J0; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 877..1066
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1095..1189
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1228..1287
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1339..1425
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..855
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW65239.1"
FT NON_TER 1425
FT /evidence="ECO:0000313|EMBL:KFW65239.1"
SQ SEQUENCE 1425 AA; 159553 MW; 10E56682E02CC858 CRC64;
FPSFLEIKKP PVAPKPKFVV GHKATPPPVA PKPDIVLSGV IQAARKTKPA IAPKPKVLKS
SSVPEVKPPS STRKSTKSFE EHRGDSSQTL DHLNYKNEAL EGSTDNTAYI LPMSSCKFEC
LHKLGNGDTT CKTQIIFEHL ENLENIKVGE KNALTLGDSH NEKLANRNQV VLKASILEEK
LKDVLTHSVF PNSSPVRHRY ADKLDKGDGS SSKNNLKIEF MELVQSSLSS EVAIGKQQNT
NSKLTADEFR MSEICPSLTE NNHSCSCPLD QEILENENLS SNSTFSGEMG MKADADKTSS
ETSSVLSLKV LPIPKPRKPR AACLVRQDGI DTTGEGTKGP CNSERDSFGL AEQSFKKPAK
INILGQSVCY NNNTEVLHPE KCEITQSNAD RMHQVKEPAT EESTSQNLLP HLSHKTSDLV
ESVECSLDAD HDLVNSMDEM TDDTSMLDAV DKRTNFVRCD TLSMSLPKQL KLTSSQHSSA
SNSLHVSPQK LEDKEVKIKD ESSPKIVPKK PQRHSLPAAG LLKKAASAEL VEKSSYTSNE
DKSNSVLEGS HFACPPAKER CVLSSCDMPK RSSEKPVWKL PHPILPFSGN SESLKTANIA
TSFNHLTVVT KPRAKSLSSV DMERTDKPCK DHQKKNSLKK FLNIKLSVCL MKSDFQKFLS
KGSQSMDSAI ANLSTGDGHG SGSNRNIASV GSERKAKSAK AHSVEISSPA LQKKRQRNRS
QPEMRSNQRL ESLDGHVLSG ENLSQMHLNS VTSTCAPEYE NVRHYEEIPE YENLPFAMGA
RRNLCFEWQN SSSVEDQSPG FYEVEDACEA TNRRLRLGRS LEEHHGHPNV VMGDLQSDED
DIMNSSDEDD DTNSDSSKGE PDPQEYKQSK AAGKKTKVYH IAKEIMSSEK VFVDVLKLLH
IDFRDAVAHA SRQLGKPVIE DRILNQILYY LPQLYELNRD LLRELEERLS HWLEHQRIAD
IFVKKGPYLK MYSTYIKEFD KNVALLDEQC KKNAGFASVV KDFEMSPRCA SLALKHYLLK
PVQRIPQYRL LLTDYLKNLL EESADYRDTQ DALAVVIEVA NHANDIMKQG DNFQKLMQIQ
YSLNGHHEIV QPGRVFLKEG TLMKLSRKVM QPRMFFLFND ALLYTTPVQS GMYKLNNMLS
LAGMKVKKPT QEAYQNELNI ESVERSFILS ASSATERDEW LEAISKSIED YTKKRITFNP
SKSLEEADPE KQEEDSPLGS KAPIWIPDTR ATMCMICTSE FTLTWRRHHC RACGKIVCQA
CSSNKHGLDY MKNQPARVCD HCFRELQKQD NQCTPKSGSP VNHKSPSSAL STVLHSIPSG
RKQKKIPAAL KEVSANTEDS TMSGYLHRSK GSKKPWKHLW FVIKNKVLYT YAASEDVAAL
ESQPLLGFTV SEVKDENSES RVFHLLHKNT LFYIFKADDP HSAQK
//
