ID A0A093R4G3_PHACA Unreviewed; 1259 AA.
AC A0A093R4G3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:KFW95631.1};
DE Flags: Fragment;
GN ORFNames=N336_08431 {ECO:0000313|EMBL:KFW95631.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW95631.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW95631.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW95631.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KL446713; KFW95631.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093R4G3; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 241..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1098
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1209..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 602..767
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW95631.1"
FT NON_TER 1259
FT /evidence="ECO:0000313|EMBL:KFW95631.1"
SQ SEQUENCE 1259 AA; 140679 MW; 85DA2C7477C6D621 CRC64;
VLSQLCVWYG ECGVASGDKR YNCAYDGPPI ALPKDGYDLM QELCPGFFFG NVSTCCDVRQ
LQTLKNNLQL PLQFLSRCPS CFYNLINLFC ELTCSPNQSD FLNVTSTIPY YDPILKENKS
SITELQYFVG ESFANAMYNA CKDVEAPSSN VKALGLLCGK DVKDCNATNW IEYMFSKDNG
QTPFSIIPIF SDVPVHGMNP MNNATKGCNE SVDDSTGPCS CQDCSIVCGP KPQPPPSPAP
WLLFGLDAVY IIMWISYMGF LLVFFALVFG VWCYRRRHFV SEYTPIDSNV TFSVNSRLDN
GKITCGERLG ERFENGLRMT FTSWGAFCVR NPRPVILFSV VFVAMCCSGF VYVKATTNPV
DLWSAPSSQA RKEKEYFDTH FGPFFRTEQL IIQAPNSHPD TYSPYPSGSD VPFGPPLSKE
ILHQVLNLQD AIVNITASFD NETVMLKDIC LAPLAPYNNN CTILSVLNYF QNSHSVLDHT
IGDEFFVYAD YHTHFLYCVR APASLNDTSM LHDPCLGTFG GPVFPWLVLG GYDDDNYNNA
TALVITFPVN NYYNDSRKLM KALAWEKEFI NFVKNYKNPN LTIAFSAERS IEDEINRESK
GDISTVLISY IVMFLYISIA LGHIQSCRRL LVDSKISLGI AGILIVLSSV ACSVGIFSYF
GIPLTLIVIE VIPFLVLAIG VDNIFIIVQT LQRDERLEGE TLDKQIGRVL GDVAPSMFLS
SFSETVAFFL GTLSTMPAVR TFSLFAGMAV LIDFILQVTC FVSLLGLDIK RQERNRLDIL
CCIKSNEETS SVQRSESILF LFFKNLYSPY LLKDWMRPIV VAVFVGVLSF STAVMHNVEI
GLDQSLSMPG DSYVMDYFSQ LSKYLHAGPP VYFVLEEGHN YTSLEGQNMV CGGMGCNNDS
LVQQVFNAAE IGSYTRIGYA PSSWIDDYFD WVKPQSSCCR VYNTTGQFCN ASVTDPSCTR
CRPLTQEGKQ RPQGKDFMTF LPMFLSDNPN PKCGKGGHAA YNSAVNFINN KSDVGATYFM
TYHTVLKTSS DFIDAMKKAR IIADNITETM GIKEKNYRVF PYSVFYVFYE QYLTIVHDAI
FNLCISLGSI FLVTTVLLGF EVWAAVIISV TIAMIIINMF GVMWLWSISL NAVSLVNLVM
SCGIAVEFCS HVTRAFTVST KGSRVERAEE ALSHMGSSVF SGITLTKFGG IVVLAFSKSQ
IFQIFYFRMY LAMVLLGATH GLIFLPVLLS YIGPSVNKAK TRAAQERTRG TERERLFYF
//
