ID A0A093R974_PYGAD Unreviewed; 1320 AA.
AC A0A093R974;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE Flags: Fragment;
GN ORFNames=AS28_14473 {ECO:0000313|EMBL:KFW67584.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW67584.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW67584.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW67584.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; KL225117; KFW67584.1; -; Genomic_DNA.
DR STRING; 9238.A0A093R974; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF407; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 290..657
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 298..361
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 862..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW67584.1"
FT NON_TER 1320
FT /evidence="ECO:0000313|EMBL:KFW67584.1"
SQ SEQUENCE 1320 AA; 150483 MW; BB52C4BFB5A090DE CRC64;
STFFQFGASI QQEAIVMLKI MQDYDWHVFS LVTTTFPGYQ DFINVIKTTV ENSFVGWDMQ
NIIVLDTAFG DAKTQIQLKK IHSSVILLYC SKDEAVYILD EARSLGLTGY DFFWIVPSLV
SGNTEITPKE FPSGLISASY DEWDYSLEAR VRDGLGIIAT AASAMLEKYS FIPEAKTSCY
GQLEKNDRPS HTLHKFMMNV TWEGKDLSFT ADGYQAHPRL VVIVLNNDRE WEKVGKWENN
SLSLKYSVWP RYSSFADSDP DDNHLSIVTL EEAPFVIVED VDPLMESCQK NTVPCRKFVK
INNSTNEGTN VKKCCKGFCI DILKKLSKTV KFTYDLYLVT NGKHGKKVNN VWNGMIGEVV
YHRAVMAVGS LTINEERSEV VDFSVPFVET GISVMVSRSN GTVSPSAFLE PFSASVWVMM
FVMLLIVSAM AVFIFEYFSP VGYNRNLAQG RDPHGPSFTI GKAVWLLWGL VFNNSVPVQN
PKGTTSKIMV SVWAFFAVIF LASYTANLAA FMIQEEFVDQ VTGLSDKKFQ RPYDYSPPFR
FGTVPNGSTE RNIRNNYPDM HLYMTKYNQK GVEDALVSLK TGKLDAFIYD AAVLNYKAGR
DEGCKLVTIG SGYIFATTGY GIALQKGSPW KRQIDLALLQ FVGDGEMEEL ETLWLTGICH
NEKNEVMSSQ LDIDNMAGVF YMLAAAMALS LITFVWEHLF YWKLRFCFTG VCSDRPGLLF
SISRGIYSCI HGVHIEEKKK SPDFTLTNSQ TNMLKLLRTA KNMTNINPSR INSPKRTADF
IQRGSLIMDM VMDKGNLIFS DNRSFQTKDN FFGDNMSELQ TLPGNRHKDN LNNYVFQGQH
PLTLNESNPN TVEVAVTAEA KVNSRPRQLW RKSVESLRQE SVRQSQGSQR ENGSDENRQL
SVKSQRYLPE EIVHSDVSET SSRATCHMEP ENNNKHHKTK DNFKKRTVAS KYPKDCSEVE
LTYLKTKQSS PRDKIYTIDA DKEPGFRLDT PQYIENIVLP ETIEFPDVYQ DHNDNYRKAE
HADRTPLHNE DSLPNNDQYK LYAKHYTLKD KNASLVDMND RYRQNSTHCR SCLSNLPTYA
GHYSSRSPYK CDACLRMGNL YDIEEDQMLQ DTTNLSLPEE IDEHSWSQNN ALQYHKKNKL
RISRQHSFDN IADKSREIDI GRPSRSISLK EREKFLQSSP YASMFSVPSS KLLSNKTSLL
THALEDSKRS KSLYPVHSDD NPFLHSYGDD QHLSLRRSPA DLYKHSLPTR GRNDNYLRSS
IKSTASYCSR DGRIHNDMYI SEHVLPYVAN RNSLYSTPRV LNSCSNRRVY KKRPSIESDV
//
