ID   A0A093RE66_PHACA        Unreviewed;       529 AA.
AC   A0A093RE66;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE   AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
GN   ORFNames=N336_06061 {ECO:0000313|EMBL:KFW94337.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW94337.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW94337.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW94337.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004573}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
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DR   EMBL; KL441609; KFW94337.1; -; Genomic_DNA.
DR   RefSeq; XP_009509197.1; XM_009510902.1.
DR   AlphaFoldDB; A0A093RE66; -.
DR   GeneID; 104050100; -.
DR   KEGG; pcao:104050100; -.
DR   CTD; 7299; -.
DR   OrthoDB; 70287at2759; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..529
FT                   /note="Tyrosinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001890411"
FT   TRANSMEM        474..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          202..219
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          383..394
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   529 AA;  60256 MW;  244011EC34F7EACA CRC64;
     MLLFAMGFLL VILQPSTGQF PRACANRQSL LRKECCPPWD GDGSPCGELS SRGSCQNILL
     SQAPLGPQFP FTGVDDREDW PSVFYNRTCK CEGNFMGFNC GECKFGFSGP NCTERRLRTR
     RNIFQLTTSE KDKFLAYLNL AKNTPSQDYV IATGTYTQMN NGSNPMFRSI NVYDLFVWMH
     YYASRDTLLG GSNVWQDIDF AHEAPGFLPW HRVFLLIWER EMQKITGDEN FTIPYWDWRD
     AEDCVVCTDE YMGGRHPTNP NLLSPASFFS SWQVICTRSE EYNSQQALCN ATGEGPILRN
     PGNNDKSRTP RLPSSAEVEF CLSLTQYESG SMDKMANYSF RNTLEGFADP RTAISNISQS
     GLHNALHIYM NGSMSQVQGS ANDPIFVLHH AFVDSIFERW LRRHRPMLEV YPAANAPIGH
     NRENYMVPFI PLYRNGEFFK PSRELGYDYA YLQEPALDSF QEFLIPYLEQ ARQIWAWLVG
     AAMIGGIITA VLTGLILACR KKRRGTSSEI QPLLIESEDY NNISYQSNF
//