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Database: UniProt
Entry: A0A093RGV8_PHACA
LinkDB: A0A093RGV8_PHACA
Original site: A0A093RGV8_PHACA 
ID   A0A093RGV8_PHACA        Unreviewed;       676 AA.
AC   A0A093RGV8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
DE   Flags: Fragment;
GN   ORFNames=N336_08799 {ECO:0000313|EMBL:KFW95212.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW95212.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW95212.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW95212.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC       {ECO:0000256|RuleBase:RU363067}.
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DR   EMBL; KL445040; KFW95212.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093RGV8; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.450.40; -; 2.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   InterPro; IPR023174; PDEase_CS.
DR   PANTHER; PTHR11347:SF23; CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00065; GAF; 2.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS00126; PDEASE_I_1; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   3: Inferred from homology;
KW   cGMP {ECO:0000256|ARBA:ARBA00022535};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363067};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR623088-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238}.
FT   DOMAIN          483..676
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   ACT_SITE        559
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-1"
FT   BINDING         563
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT   BINDING         599
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT   BINDING         600
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT   BINDING         600
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW95212.1"
FT   NON_TER         676
FT                   /evidence="ECO:0000313|EMBL:KFW95212.1"
SQ   SEQUENCE   676 AA;  78414 MW;  4B341C65AB3E124F CRC64;
     VNKDAVEKYL ENNPQFAKEY FDRKMRAEVL GSIFKVSPGE VKEGVSFKDM SRLEECNILF
     ELITEIQDEG GVMEKIVHKA LQRLAQLLTA DRCSMFICRS RNGIPEVATR LLNVTPTSSF
     EENLVNPDNE TVFPLDIGIA GWVAHTKKFF NIPDVKKNNH FSDFLDKKTG YTTISMLATP
     IMQGKEVLAV VMALNKLNAT EFSKEDEEVF KKYLNFIALA LRSHHTSYLY NIESRRSQML
     LWSANKIFEE LTDIERQFHK ALYTIRMYLN CERYSVGLLD MTKEKEFYDE WPIRLGEAEP
     YKGPKTPDGR EVNFYKIIDY ILHGKEEIKV IPSPPADHWC LASGLPTYVA ENGFICNMMN
     APADEYFTFQ KGPVDETGWV IKNVLSLPIV NKKEEIVGVA TFYNRKDGKP FDEYDEQIIE
     TLTQFLGWSV LNTDTYDKMN KLENRKDIAQ EMLMYQTKAT PSEVQSILKY KEKLNVNSTE
     DCDEKDLIRI LKEELPDPKD LELYEFRFSD FPVTEHGLIT CGIRLFFEIN VVEKFKVPAE
     VLTRWMYTVR KGYRDITYHN WRHGFNVGQT MFTLLMTGKI KKYYTDLEAF AMVAAAFCHD
     IDHRGTNNLY QMKSAAPLAK LHGSSILERH HLEYSKTLLQ DESLNIFQNL NKRQFETVLH
     LFEVAIIATD LALYFK
//
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