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Database: UniProt
Entry: A0A093S8L3_PHACA
LinkDB: A0A093S8L3_PHACA
Original site: A0A093S8L3_PHACA 
ID   A0A093S8L3_PHACA        Unreviewed;       454 AA.
AC   A0A093S8L3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 8 {ECO:0000313|EMBL:KFW79169.1};
DE   Flags: Fragment;
GN   ORFNames=N336_11100 {ECO:0000313|EMBL:KFW79169.1};
OS   Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC   Phalacrocorax.
OX   NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW79169.1, ECO:0000313|Proteomes:UP000053238};
RN   [1] {ECO:0000313|EMBL:KFW79169.1, ECO:0000313|Proteomes:UP000053238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW79169.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR   EMBL; KL415212; KFW79169.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093S8L3; -.
DR   MEROPS; M12.208; -.
DR   Proteomes; UP000053238; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR   PANTHER; PTHR11905:SF20; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 2.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00068}; Integrin {ECO:0000313|EMBL:KFW79169.1};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT   DOMAIN          131..328
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   DOMAIN          329..415
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   ACT_SITE        267
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         266
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         270
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         276
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   DISULFID        387..407
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW79169.1"
FT   NON_TER         454
FT                   /evidence="ECO:0000313|EMBL:KFW79169.1"
SQ   SEQUENCE   454 AA;  49796 MW;  1D8A00D372FF9F4E CRC64;
     RELLGQHYTE THYSADGTEI VEKPDVLDHC FYQGYVQDYA DSAASISTCG GLSGFFRVNE
     TTFLLEPLEK DASGLHAVYR AAHLRGKRST CQEAGDTLEY DHAPKIPAAM KLYRWVKDCF
     SSFSPLHKGP RYVELVLVVD NEEFRKHKDL RAVQNRMKEI VNHVDKVSPG AWIFPPCYEP
     QCQHRHECMA VGPKEHVTAA SQLSRWREAE LLQRKPHDNA QLITGIDFHG TTVGLAKKLV
     MCTRDSGGVN QDHSTNPIGA ASTMAHEMGH NLGMSHDEDI AGCHCPVPKA DGGCVMAASV
     GLVYPKLFSR CSEQDMWQFL GDPRTGCLGP VCGNQFVERG EQCDCGTPEE CLDHCCNATT
     CQLSEGAECA QGDCCQDCKV KAAGSLCRAS KNDCDLPEHC SGLSAECPED VFQENGISCQ
     NGNGYCYNGA CPSHGEQCRT LWGTEAQVAP DVCF
//
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