ID A0A093SZ64_9PASS Unreviewed; 656 AA.
AC A0A093SZ64;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
DE Flags: Fragment;
GN ORFNames=N305_06086 {ECO:0000313|EMBL:KFW87789.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW87789.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW87789.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW87789.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; KL693574; KFW87789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093SZ64; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 175..613
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW87789.1"
FT NON_TER 656
FT /evidence="ECO:0000313|EMBL:KFW87789.1"
SQ SEQUENCE 656 AA; 75986 MW; B406815D7C768375 CRC64;
EIHIKEPIEK EVNPRLLPGE LLLCEASTVY KYMQEDGSNR GAYGKLVCTN FKISFLDDDS
ASDDNEPEFK NKIVGENDIT LQCVDQIYGV YDEKKKLLTG QLRKYPERLI IYCKDLRVFN
FCLRYTKEEE VKRIVSGIVH HSQTPKLLKR LFLFSYASAA PNNTGKYGRN QTVMFDTLED
WRDELERTKG NVKYKAVITN EGYRVSEKLP LYFVVPICIS EESILKYEGR AIPIWCWSCH
NGAALLKMSA FPKEQDDSTS QMQKAFLDGI YKTISKPPYE LLKVDDLSSS LPSLQDIQTA
YTRFKQLFLI DNSTDFWATD VKWFSLLEST NWLEIIRRVL KKAIEVAECL ERQHTNVLLI
EETATDLCCV ISSLVQVMMD SYSRTKSGFQ SLIQKEWVIG GHSFLDRCNH LRKSEKEEAP
VFLLLLNCVW QLVQQYPPAF EFTETYLTVL SDSLYVPVFS TFFFNSQHQR DTSTSGESLK
TQSGPFRFLT VWDWSVQFDP KAQAFLNNSF YAEKPKPDKS QRKTTRFKHQ RQLSLPLTQA
KPSTKRGFFR EETDHLIKNI LGRRIGKFIN SSDEPPNNLR EFYDSWHSKP VDYHGLLLPR
IDGPEIKVWA QRYLRWIPEA QLHGGGTIAI TAKILDLMEE VQSLQVKIEE EHSQAV
//
