ID A0A093TEG4_PHACA Unreviewed; 425 AA.
AC A0A093TEG4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dorsalin-1 {ECO:0000313|EMBL:KFW92744.1};
DE Flags: Fragment;
GN ORFNames=N336_09575 {ECO:0000313|EMBL:KFW92744.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW92744.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW92744.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW92744.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL435534; KFW92744.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093TEG4; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19400; TGF_beta_BMP9; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF157; GROWTH_DIFFERENTIATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001891383"
FT DOMAIN 313..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 283..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW92744.1"
FT NON_TER 425
FT /evidence="ECO:0000313|EMBL:KFW92744.1"
SQ SEQUENCE 425 AA; 47879 MW; ED4E88C47C5188CC CRC64;
FGVLAALSIC NIIACLTRGK PLEDWDKLSA MGKSDAQFHD PGEVEDETHF NFKSFLENMK
TDLLRSLNLS KVPSQVKTKE EPPQFMIDLY NRYAADKSSI PASNIVRSFS TEDVVSLASP
EENPFQKHIL LFNISIPRYE EITRAELRIY ISCHKEVGSP SRLEGNLVIY DVLGGDHWEN
PESTKSFLVS HNIQECGWEM FEVSSAVKRW VRADKLKTKN KLEVVIQSKA LGGFTCGKLD
ISVTPDTKNL PLLIVFSNDR SNGTKETKVE LREMIVHEQE SVLKKLGKNN TSSEEEEQRE
EKAITGPHQH SSRSKRSIGA NHCRRTPLHV NFEEIGWDSW IIAPKDYEAF ECKGGCFFPL
TDNVTPTKHA IVQTLVHLQN PKKASKACCV PTKLDSISIL YKDDAGVPTL IYNYEGMKVA
ECGCR
//
