ID A0A093TK87_PHACA Unreviewed; 1080 AA.
AC A0A093TK87;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=ribonuclease III {ECO:0000256|ARBA:ARBA00012177};
DE EC=3.1.26.3 {ECO:0000256|ARBA:ARBA00012177};
DE Flags: Fragment;
GN ORFNames=N336_03026 {ECO:0000313|EMBL:KFW94649.1};
OS Phalacrocorax carbo (Great cormorant) (Pelecanus carbo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Suliformes; Phalacrocoracidae;
OC Phalacrocorax.
OX NCBI_TaxID=9209 {ECO:0000313|EMBL:KFW94649.1, ECO:0000313|Proteomes:UP000053238};
RN [1] {ECO:0000313|EMBL:KFW94649.1, ECO:0000313|Proteomes:UP000053238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N336 {ECO:0000313|EMBL:KFW94649.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000109};
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DR EMBL; KL442824; KFW94649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093TK87; -.
DR Proteomes; UP000053238; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd19877; DSRM_RNAse_III_meta_like; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR HAMAP; MF_00104; RNase_III; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR044442; RNAse_III_DSRM__animal.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR11207:SF0; RIBONUCLEASE 3; 1.
DR PANTHER; PTHR11207; RIBONUCLEASE III; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF14622; Ribonucleas_3_3; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS00517; RNASE_3_1; 2.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000053238};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..762
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 813..939
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 966..1040
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW94649.1"
FT NON_TER 1080
FT /evidence="ECO:0000313|EMBL:KFW94649.1"
SQ SEQUENCE 1080 AA; 126008 MW; CEB153ECBEFD66A7 CRC64;
RERERERHRH RESRRSPSPD RSYKKDYKRA GSKLFVFYYK TVTVKIITRI AFVCFVPLSR
SPSRERKRPR WEEDRERWSE NQSSSKEKNY TAVKDKESEE NASEKNEEED EELLKPVWVR
CTHSESYYSN DPMDQVGDST VVGTSKLRDL YEKFDEELGK RQAKAKAARP PWEPPKTKLD
EDLESSSDSD CDSEDDSSCS SSSDSEVFDV IAEIKRKKAH PDRLHEELWY NDPGQMNDGP
LCKCSAKARR TGIRHGIYPG EEPIKPCRPM TNNAGRLYHY RITVSPPTNF LTDRPTVIEY
DDHEYIFEGF SMFAHAPLTN IPLCKVIRFN IDYTIHFIEE MMPENFCVRG LELFSSYLFK
DILELYDWNL KGPSTDNDSI SCPRFHFMPR FVRFLPDGGK EVLSMHQILL YLLRCNKALV
PEEEIANMLQ WEELEWQKYA EECKGMIVTS PGMKPSSVRI DQLDREQFNP DVITFPIIVH
FGIRPAQLSY AGDPQYQKLW KSYVKLRHLL ANSPKVKQAD KQKLSQREEA LQKIRQKNTM
RREVTVELSS QGFWKTGIRS DVCQHAMMLP VLTHHVRYHQ CLMHLDKLIG YTFRDRCLLQ
LAMTHPSHHL NFGMNPDHAR NSLSNCGIRQ PKYGDRKVHH MHMRKKGINT LINIMSRLGQ
DDPAPSRINH NERLEFLGDA VVEFLTSVHL YYLFPTLEEG GLATYRTAIV QNQHLAMLAK
KLELDRFMLY AHGPDLCRES DLRHAMANCF EALIGAVYLE GSLEEAKQLF GRLLFNDKDL
RDVWLNYPLH PLQLQESNTD RQLIETSPVL QKLTEFEDAI GVIFTHVRLL ARAFTLRTVG
FNHLTLGHNQ RMEFLGDSIM QLVATEYLFI HFPDHHEGHL TLLRSSLVNN RTQAKVAEEL
GMQEFAITND KTKRPVALRT KTLADLLESF IAALYIDKDL EYVHTFMNVC FFPRLKEFIL
NQDWNDPKSQ LQQCCLTLRT EGKEPDIPLY KTLQTVGPSH ARTYTVAVYF KGERIGCGKG
PSIQQAEMGA AMDALEKYNF PQMAHQKRFI ERKYRQELKE MRWEREHQER EPDETEEARK
//
