ID   A0A093ULR6_TALMA        Unreviewed;      1575 AA.
AC   A0A093ULR6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 {ECO:0000313|EMBL:KFX40870.1};
GN   ORFNames=GQ26_0890030 {ECO:0000313|EMBL:KFX40870.1};
OS   Talaromyces marneffei PM1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX40870.1, ECO:0000313|Proteomes:UP000029285};
RN   [1] {ECO:0000313|Proteomes:UP000029285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PM1 {ECO:0000313|Proteomes:UP000029285};
RX   PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA   Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA   Lin X.;
RT   "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT   of Dimorphic Transition in Penicillium marneffei.";
RL   PLoS Genet. 10:e1004662-e1004662(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFX40870.1}.
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DR   EMBL; JPOX01000089; KFX40870.1; -; Genomic_DNA.
DR   HOGENOM; CLU_000680_23_2_1; -.
DR   Proteomes; UP000029285; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          844..1118
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          113..151
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        20..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1575 AA;  176265 MW;  2C532F842948A57F CRC64;
     MVDATEEEPA TVPAPVTRSG RVITPSTRAR EATGSADNTS TAKAPKKAMT QMELTGVKKA
     ANLIEEKQSA KDGSKDLLRK ICQYLESTVL EVKGLQESLC KQEKIIKEQS EMIREQSGTI
     KALQTQVESI QSQSAEEYKQ LREQLDNIAN TPVKATYAAV VENQPGHQQN EPQGPLGRPT
     FANVLFCTID TSRVGEEDKP KAQIAKVRQM IEKEIQAKGE MKNWRCAAVV KDAKNPDRVK
     VICRHEDEIQ LVKEAAPKLN IPGLRVLRDQ LYPVKIDNVN RTAVLDTDGN ILPGAAEVLG
     KENNVDIAKI SWLSKKDSNK AYGSMVVYIT KGIDARRLIE GEYFDIAGES AYTRLFEPRI
     GLVQSKTVEY ASYSLMYKSL RVLQLNVGKR DMIQQSLMND NKIRDYGAIA ISEPYARMIE
     NTLVTSPMGH SYWTKMIPTE RQEGRWPIRS MLWVRSDIDA EQIPVASSDL TAAILQLLDR
     AVLVVSVYVE GSNDEALIST VRQLHNLSVN IRGREGRRTD VLIMGDFNRH DQLWGGDHIS
     SVRQGEADAL VDYMAEHSLH SLLPRGIKTW QSGDIETTID LALASTELAE EMVRCCIHYT
     NHGSDHQAIE TEFDISIPDR SADARLLWKN APWAEIRSRV ATNLQAAPLD GSVQQQTDRL
     MTAVMEAVMK LTPKAKPSPY AKRWWTTDLT QLRRIYTYQR NQARSQRRAG RAIPELEQRA
     KEAAKEYHDA IRRQKKAHWE DFLADDTNIW QASRYLKPSG CLFSDKIPPL SKPDGSTTKD
     NVEQAEELLS IFFPPLPARI EDEGILPQRP PIHMPDLTIE EIERKVFEAK PWKAPGEDGL
     PAMTSLRDSE LPSQWRNAKI IPLKKPAKEN YSLAKSWRPI SLLSTLGKIL EAVIAERISY
     AVETFGLLPA NHFRARKRRS AEQALLLLQE EIYKAWRTKK VFSLVSFDVA GAYNGVFKER
     LLQRLRARGM PDIIIKWINA FCSRRTATII VNRLPSEQQD LLQAGLPQGS PLSPILFLFF
     NADLVQQRIS AAGGSIAFVD DYTAWVTGAS AEVNHSNIQA TIDRALDWER RSGATFEHDK
     TAIIHFTRTA SRSSSTPFMI DGKLIQPKDS AKILGVVMDS RLRFKEHIAN AATKGLIAAI
     ALRRLRMKQG AIAVTGAFQT VATTVAEAEA SIQPFHIRHM EKATKLWIDI HTLPKSNPLT
     KLSTFTTQRF TSPLQKIAQS LRTTRTKWIE TIQAFTVSPW TGRIQAICEK EGDKAIETAT
     KAIGILAATS ASTKSEIVGM GGCMRDTQID GNRVSSYSTT LGKRTDQNPY TAELEAMAVA
     LECIPTETRG RWISILSSNR SALAAISQPR QQSGQATIQR IYKRTQSLRK QGNAVNAIWI
     PAYADITLKQ QAKAEAQKST RVEQQPEKQP FQAKSTAIRL ALAAIQQEWT LPEHVGKYSK
     KVDIALLGKH TRSLYDSLNW KEAKILAQLR TGMTRLNSYL NQIGIADSGL CACGQASETV
     EHFLFRCTKW TAMRDGMNQC TESKRGNLSF FLGGKSRSDR DRWQPDMKAV HAAIKYAIAT
     GRLEPESESE PEATQ
//