ID A0A093US46_TALMA Unreviewed; 887 AA.
AC A0A093US46;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=GQ26_0410640 {ECO:0000313|EMBL:KFX42765.1};
OS Talaromyces marneffei PM1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX42765.1, ECO:0000313|Proteomes:UP000029285};
RN [1] {ECO:0000313|Proteomes:UP000029285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM1 {ECO:0000313|Proteomes:UP000029285};
RX PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA Lin X.;
RT "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT of Dimorphic Transition in Penicillium marneffei.";
RL PLoS Genet. 10:e1004662-e1004662(2014).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX42765.1}.
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DR EMBL; JPOX01000041; KFX42765.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093US46; -.
DR eggNOG; ENOG502QWBM; Eukaryota.
DR HOGENOM; CLU_325215_0_0_1; -.
DR Proteomes; UP000029285; Unassembled WGS sequence.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR021858; Fun_TF.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00745; apbA_panE; 1.
DR PANTHER; PTHR21708:SF30; 2-REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00740)-RELATED; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR Pfam; PF11951; Fungal_trans_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
FT DOMAIN 13..171
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 208..328
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 887 AA; 98213 MW; BC5A02A722AF8BB9 CRC64;
MPGTMGSMAK SNILVVGFGG IGTITAYNLE AGGLATVTGV LRSNYDMVKE RGFKIWSCDH
GDIPSWRPST ISKNVPNVEA ESLTPFDYVV VCTKNIPDIP PTVADIIAPA ITAGHTAIVL
VQNGINIEKP IIAAFPSNVA ISGISRMSSA ELAPGQIFHQ DHDILIIGAF RNPNLELKTE
LKAAKHFADL YNAGGKATGQ YDEDVTFMRW RKLVYNASFN SLCAITGMDT TKLRLSGSAV
HELLLPVMLE IKNIARAAGV KLAPDQEEVS LAGDAIDAYF RPSMQQDIEK GNYMEMEIIV
GESVREAQRL GVPAPTLTFI YSLLKVLQFK TKAKKNLVTL PPMKDYGAGD ILAAFKKGLR
YFLDRCVPRN DHDEAANSVV QATTNATKHH LHVVGAKIAD SCATMGRFLS NGAMFAQFSP
VVDSMSHGPC QRNNSLVPLR LQRIFPMPGM TINLLIMPTM TYLLLHCYQR AQLLCRKNEE
DVNRVAGELQ GHDGFHNPYR KLSVLSLSFP VLLRSILSCA AEHMRSLDLC PAPLAVELHD
QAIRAIRLEL ATWNSHRTTP TSNSGLPISV GMTADESLLA AVLLQPGAIA FSGSAPISVH
THLEIGFHML TDLGYLRSSE TLKSAIPKFL LQRFAIVDLG ICVWHRRRPR IPVNTWLVGS
ANITTKDDAI HDTFDDIQPS FREMAGCPYN VYTFLNRVMH LAADMSCSPS PQSQRVIYQE
AITLETEIRT YELRISSPNQ NRSPQSVPMD AVRRAFTHAA LILLLRRVFL EPSSSPRVQN
SVEIIFTLMD NIPVTQKRTS TRAEDVYSGI DSAAGLPFYL AAREALTLEM QQIIREKHEK
WREVYPNPAR IQLMEVAERL WLQRVKDPSF SEKACEEIET SCDAYIF
//
