ID   A0A093UV02_TALMA        Unreviewed;      1065 AA.
AC   A0A093UV02;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Linear gramicidin synthase subunit D {ECO:0000313|EMBL:KFX41529.1};
GN   ORFNames=GQ26_0580300 {ECO:0000313|EMBL:KFX41529.1};
OS   Talaromyces marneffei PM1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX41529.1, ECO:0000313|Proteomes:UP000029285};
RN   [1] {ECO:0000313|Proteomes:UP000029285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PM1 {ECO:0000313|Proteomes:UP000029285};
RX   PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA   Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA   Lin X.;
RT   "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT   of Dimorphic Transition in Penicillium marneffei.";
RL   PLoS Genet. 10:e1004662-e1004662(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFX41529.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPOX01000058; KFX41529.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093UV02; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_002220_2_1_1; -.
DR   Proteomes; UP000029285; Unassembled WGS sequence.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
FT   DOMAIN          576..656
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1065 AA;  118000 MW;  A94A02198A82F71A CRC64;
     MTVNELGTAF TWPKLSLLEG EGDARSLPEL IDFQARVNPH RRFCIQAQKS TDAPLLDVTY
     AQLKHAVSCC QDWLGKNVPE IQLENGTKDR PVGLLMDSDL TLVIYLFALM GLGIPTVLLS
     TRLSAEAVKH LVQKTRTSAI LVSARLDGTA NEALSSWDAS DSSPPSKYCP AAYRDFMTEN
     TTSSTAFTES NVGRKNHFVS ESDCNVLILH SSGTTGLPKP IYTSHRHYLS FALCHEFKNA
     EEMLSPALST SPLFHGFGLL PPCLSLGMGK PFCLPEAGTI FTGPSTAQLL RNSGAKSLLT
     VPSVLEEIAL LPDDEGIHVL QELHFIVFGG GLPKETIGDK LTAAGVKLLN HYGATETGPL
     APLYVPQRGY DWHYFKLRTD IQDALQVSLE PIVEENQESE SRWKLSLQPV GWTERFPLQD
     ILVPRPSSDS DNEYTVLGRS DDLIRLATGE KVRPTIVESM LAQSEAVKAA VAFGDGQFEI
     GVLIEPTFKI SSAEEEDALK SSLWPIIQLA GEKMDAHARI SSSQAIVVVQ AGSLPRSDKG
     TVLRREVNQR FEKEIAEVYR KLDGVIDYSI PPLRLNSLEA DLRKLINDNL KWTNNSEWTD
     ERDFFELGMD SLQSTILRRL LVSSLRDGLS KVSIGRDFVY QHPSVAELAK AVREGCGNQA
     ASSVDGSLLD VFIDMYSLQR QQKSNGYGEN DTATVLLTGG TGSLGSHLLA HLVQKSVVRH
     VVCMNRPSTG KQDPYDRQAA ALKSKGLSIS PEEWSKVIVF ETNTGSPKLG LSGADYTWLC
     ERITHIVHNA WPMNFKMHVS SYKSQFRVLQ HLLLLARDAH AHQQPTRRTR VLFISSISTV
     GWYGKFTAET IVPETPIQDF RTALDLGYAQ AKLVCEKIIE RARNDFGTEI EVGYIRIGQI
     AGAQGGFWNT DEHFASLVAS SEALGHLPDI RGPRAYGTVY HLENPVRQPW NEVLDILASE
     LDVDKHNRIP MAEWLEDIMK RRPDDGNPVA ALADFFQEDF EWMSGGSIVL STETSRRHSP
     TLRRAGPVHD ETIRRYVQYW RGIGLIRGLK NQALPVDSSS LLSFS
//