ID A0A093UVF4_TALMA Unreviewed; 1529 AA.
AC A0A093UVF4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Metal resistance protein YCF1 {ECO:0000313|EMBL:KFX41719.1};
GN ORFNames=GQ26_0550380 {ECO:0000313|EMBL:KFX41719.1};
OS Talaromyces marneffei PM1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX41719.1, ECO:0000313|Proteomes:UP000029285};
RN [1] {ECO:0000313|Proteomes:UP000029285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM1 {ECO:0000313|Proteomes:UP000029285};
RX PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA Lin X.;
RT "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT of Dimorphic Transition in Penicillium marneffei.";
RL PLoS Genet. 10:e1004662-e1004662(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX41719.1}.
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DR EMBL; JPOX01000055; KFX41719.1; -; Genomic_DNA.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR Proteomes; UP000029285; Unassembled WGS sequence.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:UniProt.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR CDD; cd18603; ABC_6TM_MRP1_2_3_6_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF456; BILE PIGMENT TRANSPORTER 1-RELATED; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 61..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 308..592
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 628..853
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 958..1241
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1278..1513
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 855..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1529 AA; 171096 MW; 178670B825C17D82 CRC64;
MIDGNPQLVI GNDRSSTGSF YTAANPLHVS TTLRQPLCGN SEGWGPINSD LADFTPCFVD
VPVSITAWWG VVMGAGALWL LLKRREPQHV PKNWHFYAKL VVLALLLALT ATQAILQLVS
NAQLYIADFR FWANVWTLAS LAVIFAVQYF EHWRSRQPNG VVLFYWVFFI IAHGIKLRSL
VTREVFRYHL PYFIVITISV ALAIVEFILE YLVPKKQSAY DTLGKEDECP FEYADIFSVL
TFSWMTPMMK YGYKHFLTQD DMWNLRERDT TKTTSSLLED SWGIELEKKS PSLWIALFRA
FGGPYMRGAI IKCGSDILAF VQPQLLRYLI SFVDSYRTDQ PQPVARGVAI ALAMFAVSVC
QTACLHQYFQ RAFETGMRVK SALTGLIYSK ALRLSNEGRS AKTTGDIVNH MAIDQQRLVD
LTQFGTQLWS APFQITLCMV SLYQLVGNSM WAGIGVMILM IPINGIIARM MKTLQIVQMK
NKDSRTRLMT EILNNMKSIK LYAWNKAFMS KLSHIRNDLE LNTLRKIGAT QAVANFTWSS
TPFLVSCTTF AVFVLIDDRP LTTELVFPAL TLFNLLTFPL SILPMVITSI IEASVAVKRL
TDYLTSDELQ EDAVLFQEPV THNGDESVRI RDASFTWNKY QPNNVLENIN LSARKGELTC
IVGRVGAGKS SLLQAILGDL WKSQGEVIVR GRIAYVAQQS WVMNASVREN IVFGHRWDPH
FYELTIEACA LVDDFKTLPD GDQTEVGERG ISLSGGQKAR LTLARAVYAR ADIYLLDDVL
SAVDSHVGRH IINRVLGPTG VLNGKTRILA TNSIAVLREA DFIALIRDRT FIEKGTYEQL
MAMKGEVANL IRTISAEDDD ENDSEASRDD AKSPISLDST TVDESDMSEI EEAEDDLGAL
APIKPGGYCK LACPRRETSD EENGLKTKQT KEKSEQGKVK WSVYTEYAKE SNLYAVSIYL
FFLLASQTAQ VAGGFWLKRW SEVNEISGRN PDVGKYIGVY FAFGLGSSAL VVLQTFILWI
FCSIEASRKF HERMAYAIFR SPMSFFETTP SGRILNRFSS DIYRVDEVLA RTFNMLFVNA
ARAMFTMGVI AFSTPAFLTV IVPLGFVYMS YQKYYLRTSR ELKRLDSVSR SPIFAHFQES
LGGVSTIRAY RQTKRFAMEN EWRMDANNRA FFPSISANRW LAVRLEFIGS IVILSAAVLS
IISVSTGSGL SGGMVGLAMS YALQITQSLN WIVRQTVEVE TNIVSVERVL EYANLPSEAP
DVIFKHRPAI GWPAQGGVSF QNYSTRYRPE LDLVLKKINL DIKPHEKIGV VGRTGAGKSS
LTLALFRIIE GTEGEISIDD LDISTIGLTD LRGRLAIIPQ DPAMFEGTVR DNLDPRHVHD
DTELWSVLSH ARLKEHVAGM EGQLDAVIQE GGSNLSQGQR QLVSLARALL TPSNILVLDE
ATAAVDVETD ALLQQTLRSS IFKDRTIITI AHRINTIIDS DRIVVLDRGT VAEFDTPAEL
LRQGGKFYDL VKEANLLDSD AVTSMLGKK
//
