ID A0A093VC14_TALMA Unreviewed; 2127 AA.
AC A0A093VC14;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Conidial yellow pigment biosynthesis polyketide synthase {ECO:0000313|EMBL:KFX49730.1};
GN ORFNames=GQ26_0093000 {ECO:0000313|EMBL:KFX49730.1};
OS Talaromyces marneffei PM1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX49730.1, ECO:0000313|Proteomes:UP000029285};
RN [1] {ECO:0000313|EMBL:KFX49730.1, ECO:0000313|Proteomes:UP000029285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM1 {ECO:0000313|EMBL:KFX49730.1,
RC ECO:0000313|Proteomes:UP000029285};
RX PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA Lin X.;
RT "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT of Dimorphic Transition in Penicillium marneffei.";
RL PLoS Genet. 10:e1004662-e1004662(2014).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX49730.1}.
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DR EMBL; JPOX01000009; KFX49730.1; -; Genomic_DNA.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR Proteomes; UP000029285; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 410..822
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1648..1725
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1759..1835
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2127 AA; 233382 MW; 356578A0742D9A77 CRC64;
MDGLVNHQQP KGDYPLPLFE TRQYDRLQGK MLRERSIVFF GDLSLPIHPA LSQLLRAQTE
YSILSRFLTQ AKTALQAEAT NLSVVERKSL PSLTDLYTLS ETENSHGSDH PILAPALLVI
LQLGQFISWH EEHPEKRYPE SDSTIFAGIC VGQISATAIS LAKSLTELLP LAVDAVRIAF
RLGRLTTEAR NDLELSLEET WAIVTPRDTS IPTEDVLDRI IKESGILGRR KPYATAYFPK
TVTIQGPPST LRLVSDSLQK ARGSSHTYFA SELPIYAPYH APHLYNQDTV VEILDGVEFV
DKKNDTWATG QVKLISPTTG TFYDVSNRLD IMSKALHDIL LKPINWEKLC EGCTSVVASS
EPARWSIRPF GPSKATKSLL SAISSVTNAD IILDETFISS STSQTPTTAK EPIAIIGMSG
RFPNSTNTDE LWKLLEQGID CHKVIPADRF NASLYVSQDR NSRNKSKSPY GCFIEKPGMF
DPRFFNMSPK EAAQTDPQQR LALVTAYEAL EMAGYVPNGT PSTQLDRIGT FYGQTTDDYK
DLNTSQDIDT YYVSSVIRAF GPGRVSRSNQ LACTSIWSQE CDTAVVGGML LLGSPEMYAG
LSKGHFISET GPCKTFDDSA DGYCRGESVA SIVIKRLDAA KADNDNILAV ILGAGTNYSA
YAASITQPHG PTQEMLYRKV LNQAGLDPFD IDYVEMHGTG TQLGDAIEMS SVSNIFAPVS
PRRPIERPLH VGTVKPNIGH GESASGITSL IKALLILREE RIPPHIGIKS GVLNHTFTDL
QRRNVHIPLE TAAFPRSQSR KRRLMVNNFG AAGGNSAFIL EEGPIYEGHG VLDSRPDHVI
SVTAKTAFSL QKNISNLIAH LEQYPQVSLS DLSYTTTARR VQHPLRASAI ASNVDELKGR
LVQLLETIPP KPASGKFPGV AFAFTGQGSV YLSLGQQLFE TSSQFRADMR RFDQICQGYE
FKTFLPVIDG SATNLNDLSP TQAQLALVSV QIALARLWAS WGITPNFVIG HSLGEYAALN
VSGVLSISDT LYLVGIRASF LETLCTKNTH SMLAIHATLD AVKSAAENKL GRLELACVNG
PEDIVLSGLF KDIQELSQHL KQQGFKCTVL QVPFAFHSSQ TDPILDSLEK AAQSVRFLKP
EIPVVSTLLG AVVDEIDVFG PSYLRRHARE PVNFDGALRQ ACFDGLTDAQ TIWLEIGPEP
ICLAMVKSIL GSEIKAFPTL RKSEAPWKTS AKTVSALHSL GFDITWKEYH RDFEGGQRLL
HLPSYAFDEK NYWIDYRNDW LLHKGKDIVK QMDTPRINSG PATTTVQTLI TEEVKDGTVF
VVFESNLSEP KLNALIAGHS LNGLALCPSH QAKLPASSGS NIVDMQIVKP VTITVPRVDT
PELLRISGTA NLEKGIVEVT FGTYSSKSGK TDQNAKCIIE FGDTKLWLNH WSRSAYLIQK
RIEDLERGVK NGDVDKLFEK TIYRLFSAVV DYDPRYHGMK EVMINSNELE AVALVKLYEG
TDAGDFFCSP LWLDNLAQLA GFIMNGVNVV DPRKFVYISH GWGSYQLADD IDPTKPYHVH
VKMHPAEKNV VVGEVSIFQG DTMIGLCSSI KFQKVPRSLM EMLLAPPSHQ QQSSVQIPNQ
RPTLSSAKQA RVIPPRKAAV LPEYSSGKST PGIKSMALET IAQEIGVTAA ELVDSATFVE
FGLDSLMALT ILSKLRESLQ LDLPSDIFQE LTTIGDLRGF LDKFDNTNEG NVDTPSTDAM
SPILATPEPL FEDETSIAGD MLNSVYSIMA KQIGVEVEEL LAVDDLSSLG LDSLMSLSIQ
GSIQEELSLK LELQFDGSAK LPTLVNIQEA LGLSPAEPLI IPQPLIPATS HRAGLGPSAS
TLLLQGNPRS STKFLFLFPD GSGSAAAYAA LQEISPDLVV YGLNSPFLKS ADKYTCSIEE
IATIMVQAVR SIQSHGPYTL AGWSAGGMYA FEAARQLIQA GELVSKLILI DSPCRSTYEP
MPANLLEFIM SSTILKGFTD KSAPNRIVDH FKSTIRALQI YSPTKLDASR APEVFIIWAK
NGLSEDLGNN ERGNVDWSRG VANWLFHREA NAGPLGWEKL LPGRPISVAD VAGNHFSMVN
KSNSKSLSLA ISDVLRDDLR KQQWRIF
//
