ID   A0A093VGR0_TALMA        Unreviewed;       836 AA.
AC   A0A093VGR0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase {ECO:0000313|EMBL:KFX51355.1};
GN   ORFNames=GQ26_0051720 {ECO:0000313|EMBL:KFX51355.1};
OS   Talaromyces marneffei PM1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX51355.1, ECO:0000313|Proteomes:UP000029285};
RN   [1] {ECO:0000313|EMBL:KFX51355.1, ECO:0000313|Proteomes:UP000029285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PM1 {ECO:0000313|EMBL:KFX51355.1,
RC   ECO:0000313|Proteomes:UP000029285};
RX   PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA   Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA   Lin X.;
RT   "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT   of Dimorphic Transition in Penicillium marneffei.";
RL   PLoS Genet. 10:e1004662-e1004662(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFX51355.1}.
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DR   EMBL; JPOX01000005; KFX51355.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093VGR0; -.
DR   eggNOG; ENOG502SKBE; Eukaryota.
DR   HOGENOM; CLU_339859_0_0_1; -.
DR   Proteomes; UP000029285; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   PANTHER; PTHR46082:SF6; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..836
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001892536"
FT   DOMAIN          11..130
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
FT   REGION          579..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          766..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..617
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..753
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        776..797
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..828
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  93582 MW;  2E54C55EA8F2361F CRC64;
     MRPRSRSDFA IAIICALPLE ADAVEALFDE TYDRLGRLYG KQPGDANAYV NGRIREHDVV
     LCYMPRMGKG SAASVASSLR VSYTGVQLAL VVGICGGVPY PSASNNTEIF LGDVIISDAV
     VEYDFGRQYP SRFQRKTDGH NKDMLGGPDR EIRTLLTSLR ASQTRNEFQG QIIQQLYSIQ
     QLDARWRRPD SWNDILFESG YHHKHYIQES SAICRCFDGD SPDDICDEAL EHSCDSLGCD
     WDRIRRCQEE SADTTNKVSV HIGKIASADT VMKSGEHRDQ IARKERVIGF EMEGAGVWDN
     IPCIIIKGVC DYADSHKNKN WQDYAAATAA CGLKVFLGYY KIGKNTQSLV EQDMQVSINH
     LNEQSRTTII FLFFAFLYFR GLLLTLHTRL TRLINPWSEL PAILEDAHLR RFTIPLDTIN
     TWEIFDFILE KHFSDMPGYR QVKTGSYVLE DSISRSAVKH TDAFKACFRP GRRVFMSMLF
     HLKQHEKSTC PSCHAANLDS GQSDVCCSFC GMQYRRIMEV VEDDNKNERH LDSANAKRLK
     VNPARGHAFI APKTPAEADY PEEDVAQFKR VHIVAAPDTR QPAAGGKMVS NRNGLDTLNK
     NKTTNSHSSI PRPITKNKNP RISALQRHFE QLSREFQKEV QRERLQRAAE SQYSRVYPTI
     SSKPTVEVYK NIYRRPSLPA PSETSSSDSF FKSTYLGMDD VLQDTDDASS TPDDSIVNAG
     GLGERTLTPS GDGVPSRRAM VTRHDDDDGD GRHVTLRTLA EEEYAAFRER ERGGGSNTNS
     RSSGSDSRLS GESSNAERAV SVIILPSSDI ESEGGCITLP SSDISSMPPE SIHGLR
//