ID A0A093XU29_TALMA Unreviewed; 5521 AA.
AC A0A093XU29;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 39.
DE SubName: Full=Nonribosomal peptide synthetase 8 {ECO:0000313|EMBL:KFX48773.1};
GN ORFNames=GQ26_0111560 {ECO:0000313|EMBL:KFX48773.1};
OS Talaromyces marneffei PM1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX48773.1, ECO:0000313|Proteomes:UP000029285};
RN [1] {ECO:0000313|Proteomes:UP000029285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM1 {ECO:0000313|Proteomes:UP000029285};
RX PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA Lin X.;
RT "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT of Dimorphic Transition in Penicillium marneffei.";
RL PLoS Genet. 10:e1004662-e1004662(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX48773.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPOX01000011; KFX48773.1; -; Genomic_DNA.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_0_1; -.
DR Proteomes; UP000029285; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 5.
DR CDD; cd19545; FUM14_C_NRPS-like; 4.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 708..784
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1784..1860
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2855..2931
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3926..4001
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4998..5074
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT COILED 1196..1223
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 5521 AA; 615945 MW; C15AD720953FE042 CRC64;
MKRMYISNFR AESSINVEDV SAAWAILLKD YIGSFDVSFS LAGPSFGPSH RIDLCMAEET
TVNEIYQEIE KQLASRDEHD TKEEDLSYRT RLHIYDARSE NSPGRLPEDE IFSNDLLVTD
GSPKVEMDLW LDVVISNNEG HVYLSARSMS TTWSETYLRR LLKQLEHVIC QIQPQENRTT
LIYNIETATE MDREQILLWN AHIPGAVEST ALKIFSNHVT KSPTAPAVNA WDGDLTYQEL
DNLSTTFAYH LISLGVGKGN IVPLCFEKSK WTVVAIWAVI KTGAAFLLVD EVLPEERLRL
LANTISEEKI LVLCSVSQYD KAKCLDSRIV VVEEEYLDKN LLRSSTPTPE CASPSDLLYI
VFTSGTTGVP KATMIQNSNI CSYVDAMEGL QNLDHKSRIL AWASYSFDVS LANIFLSFLT
GSCLCIPSSW ECKNDVAGII QRYQITYAMM TPSVSKMLRP SDSSTLEILE LCGEPCSEDA
LSRWRKTCTR VMNTYGPAEC TVTGVANGNV LLSPKSTIIG KGLGACWVVD PINRDRLAPV
GGIGELMLEG PLQHFESLAM GTRGRLYRTG DLVRYTEDGM IDIIGRRDMQ VKIRGQRVEL
GELSAHLQRI MSPTIQWIPE VVKLNKRVES LIVFIVLPED QGNRAELSQS VVNLWDSLLK
SKLHPAMVPT AYVQIAQIPL GLTDINGRDF INEEPNITAE QNNHIRVPEK SHRMEILKHV
WAELFDTDLA SMHPNSSFFE YGGDSLTAIE LVGLASRRGI QLDVAMIFRH PELSDLASWS
RFSANLMPQV PEPFSLLSRR INLNEIALAC HTYPENVEDA YPCTPLQEGL ITSSDSKSAS
YIGRASLRLP QKISLPRLKR AWERVLQVHP ILRTRIVDLP AEGLVQVILK DNGVPSESQI
SNPHSYDPEN DDLKMGLGTS LFHYAFLRDD NAKSTYLVVT MHHAIHDGWT LPRLGEELFK
AYQGEPSRKT RDELLGRAIC GRKGNHNLSR RVSGAGGSLG KELTEVDNTV TAQCHSDNIY
AIDFERAWAL VVSKNLASED ITFGATVSGR NVPINNIQDL LSPTICTIPV RVRLYGDMRV
DNFLQAIQNQ SIDAMPYENY GLQNIRKINS ETQHGTRFQT LFIVHPPNNR SLPHRQSLST
LSASEQKLKT QLENINLSSS LSSFNEYALM ITIRQESSNL EVEANYDSNI LEACQIELLL
DQLAHLTQEI SRSENMTKKL KEIRYASDSE LETIWEWNAA EHRPKRKLVH ELINQTIGAS
PEATAIRAWD GSLVYKELDR LAARIEGKLR RQGVGRNDIV PICMEKSMWT TVAMLSILRV
GAAFVVMDVR HQPKKRLQII AQEVKAKCIV TTGPATALAG ELVKDIIICD NLSDDNDDDT
ISSISEGSYS STSDIAFIVF TSGSTGIPKG IKITHENFTS TIEIHAHKLK LSSDSNIYDY
ASYSFDIAVH NSLMALTLGG CLCIPSEDDR ENDIEGSFER LGANWVDITP SVAKLIEPSA
IPSLNTLVLS GEAMTREVVE KWSTRVALIN AYGPAECQIC TIQEDVTNPT RASDIGRAVA
CSAWVVDLES GDLSPIGAIG ELVIEGPIIS PGYLNARGDA FVSNPPWLLR GSSKIPGRHG
TVYRTGDLVR YRPDGTLVYA GRATDQIKLH GQRVELGEVE FQVRQVKRDS DEVIVDLVDF
HGTSSLTAFF ASPAKDQADN KIGNVVQDTL LNLQLEIVPS DLLVKLRSIL PGYMVPAMFL
RASHLPLTPS RKVDRRKMKK LASQIPRDLL IGFEQGTKNN DDGTDLNERE VEMLDVWSQV
LKLDKSRIQR QSDFFQLGGD SISAMRLVKY CRLKSLLFTL SDVFRHSQFQ ELCKLASDAV
HDNSWPETTS KLVSPFSLLS IHHKNSLVSL AASACRVPEE VIDDMYPCTP FQEGVFAMTA
GDSSAYVQHT GIRFSDQLDL DRVLMSWATV IDKSPILRTR LVHGEESAVL FQVIIRPRPQ
EWKWYDTVAD YLSESMKVPM GPGDPLFRLG LIRAGSTSLN RSTPTLIWTM HHAVYDSWSM
DLILRQVSAH YRAEDRIYIN PNYNSFVKFI LDQEQKSAQW WGSYLRGASD ASIFPKAPMV
ESLQMTDKVI RKEFVFPDAL PPGYSPAVLL RAAWAIVMAR HTGGERVLFG ETRLGRNVSL
EGIDALVGPA IASVPILASV NRDQTISAFL TQIRDIGLEV QNFEHLGIQN IRRISEDART
ACNFQTLLVF LENKDRVDGD SLFHVDETMD DIRNFNSYYL LLYLSLSKSR FVIEAVFKDF
TVDQGMVELL LDQINVILSN FSTLPSQALI QELDTASDYD LAKIWNWNAM PSDSVDKFVH
DLISHKAREN PDKLAVHGHD GEFTYQQLDD YSTCLASLLS SRGIGLGSIV PICFEKSAIV
PIAMLAVIKT GAAFTVMDVT YPENRLKSIT SAVKAQLILS SPSQVQLAER LADKVFLVDK
STFSTNVPEA LQEVSQDTNR LMYICFTSGS TGEPKGVMVT HRNLASAAVA QTQALDFVPE
DRIYDFSSHA FDANIWHFYL GWVAGACVCI PSNEERKENL AGSITSFRST ALFLTPSVAR
SLNPQEVSTV KRLYLGGEAV TPLDVSMWKD HLDLWGAYGP TETTPLCIFT RLRSPDNASN
IGRGVGVRSW ICNPNGGELV AIGAVGEMVN EGPLVTNGYY NRPERTAAVF IENPKFLQRG
HGHISGRPGR LYRTGDLVRY CYDGTIQYLG RADTQVKLRG QRVEFGEIEY QMKHALPEMT
SVCDVVVHPS SKRPMLVAFC ASPYWKIPID KKALQMHLGK CLPSYMVPEF FFTLSDIPKN
PSGKVDRLKL RAMGVSMMQE SSSHQEKVSI ECVYGPLTEM ESRLAGLWIT ALGDSPTIIG
PESEFADAGG DSIAAMKLSN LARKHELSLT VRDILGNSRL SAMALAMTAI DNTGSTYKAF
SLLDASQRDV LRSRAARICN IPVGSIMDIY PATPLQTEVF ALTMKQPQAY MKTSAFEVPS
HLEFQKIIQA WNVVVERNPI LRTRFVQLPS GDLLQVVVKG HEWKQYDRVD SYTKASMLDS
PDLGKQLSHL AIIRQDSVIK IVWTVHHALY DEWSILILED QLRRAYKGHH IREPPAYANF
IGYLSSQNKA KAVEYWKNRL AGVTPASIYP KLPSRHHLVR PSAVYNRTLK YTGAHRGNLQ
AKVYASWTLI VAKLMGSDDV LFASTLTGRN IPVKGVEQMV GPMITPVPIR VRLGTIKQRV
DDFLTMIQNE ITEMAPFQHV GTRDIQSIDQ DTQAASKFQT LIVMTPAKEN EDQTAEHLTT
SNSELENFKG DSFHTFALVL FLFPKKSCID LQVVFDPDVL HKREIERLSG RLEKVMIDMD
EMKYISSIDC VGKEDVDDIW KWNSTVPIAS SQSLHEAIVA GGKGRSDKVA IDAWNIRITY
AQLEELSDNL SVTLLGQGVR KGSVVPLLSH KSGYVPVAAL AILKSGAAFM PLDASLPLNR
IKEIVDQVNP EFILAADSTH NIATKLQLRV ISIEGSLKST TRATNSLQRV IQIEPDDIAC
VLFTSGSTGK PKGVMQTHQS LSSAIIHQSA DTGFNENARA FEFASYGFDV SWNMIFKVLA
RGGTLCVPSD DERNNDLTGA LNRFQATLTE LTASVARLIN PADLTTLENI ILSGEPVDLR
EFDHWKPKVR SVVCYGPSEC TSVSTINRGD SGQANNRGIG KGSACVTWLV NPNNHRQLMP
VGAVGEILIQ GPIVGKGYYN NDPLTRASYT YDLPWLHAGN SVVSSRSFIS GDLATYDADG
NLHFVSRKDL QVKLHGQRIE LEEVQYHVRS ILGDLPVIAC VFNDPAKGNA QKLAIFICEK
RAIKDHQKCE FTSPDPATVG IVVTLDEKLG LIAPKYMIPS VYYFITTTPR TPNGKINRQK
LVEMALVAQP DQIYHGRTSQ QTTGRMPNSE NEITMQQLWA IALRTSENIS ADDDFFHLNG
DSISAMRLVA AARDRGFALN VATIFDNPKL SDLALKLVST RTSHLTMKPF DLLDDGVDTT
DIRGEVAVKC GIRDPDDVED VYPCTPLQEN MLAGTIRDSH AFISLRLYHV PKHVDLQRLR
DAWMSVVKKH PILRTRLVDI EKHGLNQAVI RVRDDSDLWG YSDMETFLKE NLEENMGLTT
PLTRWALIKE QDEHRLVWKI HHAVYDGWML PLIEDEVNKN YHGMESDTYL DIRPIVKYII
KEPKDASISF WSRELASAEQ SIVFPSFPHQ SKNAHPSAYL EKDLIMSTAP QSRQINISAL
LYGSWSVVVS RLTGNSKIRF GSILTGRNAP VDGIERVMGP TITTIPILID VNGSSTVQDY
MRQIQDMNIR RIPHEHFGIN AIRRINNSCK TACDFQTVLV IQPSTESAQN QASANDQAIL
EELDETTVEG FPDQYSVLNQ YGLMLELLPN GNKMKVRASF DSKVISHLQL ERILAMWEIT
IQHMMKTSNH QSISVGSLNS LCDEDLRGIW KRNEIPVNPA TTKFVLETIS EIALKQPNAL
AIDSWDGQLT YEKLDMASSL LSDRLLSMGV GPGYFVPLIF RKSMWTNVSM LAVMKSGAAF
VPLDADHPEG HLRAIMQPLN AEIILCEAST RDRASRLARC TIIVDDEVIP YVKETNLSGS
VLPLSNGISH IRDRIKPESL AYAVFTSGST GAAKGVMISH ENLATAIHYQ AGAGAYGINK
DSRTLDSSSY SFDACLVPSV ARTVDPAMLT DLKTLVLTGE PLTKGDIETW CHRVRLINAY
GPTECTILCS VSPRITGGSQ LGHIGCGSGA NLWLTEIGNP RKLAPIGAVG EILIEGPIIG
AGYLGPYEFP IVEDPPWLIA GMEGSHGRSG RLFRTGDQAR YTDDLQLVFM GRIGAEIKLR
GQRVDLFAIE DTIRRRISNH WEIAVDIVHL TLGQSGGEYE RQTLVIYVCD KKLELCSPSD
RLEGFGSALQ PIISDLKAYL DTSMPSYLQP EAFVPISFMP KTSSSKTDRR RLKAMGTQLQ
LRDLIWITGD MMAKTSTPLN TQKEKTLADL WSELLGVKYE SICKEDDFFK LGADSLAVMR
LTTKAHEKGF ELKPGDVFSC SNLERLADKM VEVSTILIKS RAYERYSLVP GIQDIGAFTS
ELIAPTLGIA PDEVEDILPA NGFQVDYIVN SEEPLGLQYA YIDIEPEVLW PDLVNAFRTV
IQAFECLRAR FYCQEGRYYQ IILKEAPLIV EEIESRGQIT TFFNQFCADD CRKAKLTDIF
SKITLVSDGH RRRVILRLSH MQNDGWCTIR IFTNIANVFN GLEVENTLKW TNLLSYRQAI
GFESREYWNE VLRDTTRLTP GLVYKPKEGK VRTLRSYALP NFHISTENRR TRPTVVVNVA
WALVLQKLAG HDDVIFGNVT TGRNGSLPGL DTVIGPCVNM LPMRLRLQNR PSLSRRAYLR
SLIEASAQQV DQRTAYEGLD WEETVNECTK WPSGSRYSSA VHFRNMAFEP QLTLGKSKVN
FAWYELVAEP HWTTVLVYPE ENVLRLWLLA NPAEIGDDGA DEILHMLAEY CDEIVDSLCE
Q
//
