ID A0A093Y1A3_TALMA Unreviewed; 1657 AA.
AC A0A093Y1A3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Autophagy-related protein 14 {ECO:0000256|ARBA:ARBA00013807};
GN ORFNames=GQ26_0051280 {ECO:0000313|EMBL:KFX51293.1};
OS Talaromyces marneffei PM1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=1077442 {ECO:0000313|EMBL:KFX51293.1, ECO:0000313|Proteomes:UP000029285};
RN [1] {ECO:0000313|EMBL:KFX51293.1, ECO:0000313|Proteomes:UP000029285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM1 {ECO:0000313|EMBL:KFX51293.1,
RC ECO:0000313|Proteomes:UP000029285};
RX PubMed=25330172; DOI=10.1371/journal.pgen.1004662;
RA Yang E., Wang G., Cai J., Woo P.C., Lau S.K., Yuen K.-Y., Chow W.-N.,
RA Lin X.;
RT "Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms
RT of Dimorphic Transition in Penicillium marneffei.";
RL PLoS Genet. 10:e1004662-e1004662(2014).
CC -!- SIMILARITY: Belongs to the ATG14 family.
CC {ECO:0000256|ARBA:ARBA00009574}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFX51293.1}.
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DR EMBL; JPOX01000005; KFX51293.1; -; Genomic_DNA.
DR Proteomes; UP000029285; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR InterPro; IPR001138; Zn2Cys6_DnaBD.
DR PANTHER; PTHR31644:SF2; TRANSCRIPTIONAL ACTIVATOR ARO80; 1.
DR PANTHER; PTHR31644; TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED; 1.
DR Pfam; PF10186; ATG14; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 682..718
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000259|PROSITE:PS50048"
FT REGION 66..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 274..319
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 66..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1657 AA; 185927 MW; 843363154C6127F9 CRC64;
MSDSNNNSRR ERPLLFSVNR KLRHLQGLSI RNLSITPPSR ARGKTIDDDD IPYSLKTPVK
LAVQAQNRSV TQSRSYTDLK SISPKVQPLD GNQEQHDKQI RESRPNRRRS TLPWSGGDLE
SRQTKLEDIA RSRMADVWFS IHCDGIDGPV YVSEVVEKTT NPDFRVLDLN VCGPHVSRMD
QLCVKVWVKS ENMSDYTLLL ELHQSFRSLQ FVGKSLETFH HPLPPNCVLF HFADGIFTNL
TDLPPTQTNL AGFTNGSPHM EPQSTSSYDA LMRLANLDDC IQDALATREK LESQINVILK
KYQKSLELLN QVSQAEEKTA LIKRGIANEK KQVRLSAKRR DELIASINAR RESMTSGREN
QNKTCTHLTD ARLKLTFSAS LLGHNREDAK GQIRRICEDL LAIYPIEPLS DKALAFTIAG
LHLPNSKFDD IDREVVAAAL GYTGHLVYLL SFYLSVPLPY PIKPYMSSTF IQDPVSAGLS
RRTFPLYPVN VQYRFEYGVF LLNKNIEVLM NRFGLRVLDI RHTLPNLKYL LYVLTARTNE
LPARKAGGVR GLLLGRSTPM MSRQNSQDSF ASSEIMPPHR MPSELLRNDA NKSQTSPTTP
PPFPLLSQAR FASGCLAHPR PLPERRRPSP RRLTTAIARM ESTHDGSMSQ DAVSLNNGSY
DESNRELRSE TPPTQHRRGY QACDPCRKRK VKCDLGSVDN PRPPPCVRCR RESKRCEFSA
TRRKRKTSDA EPEQETPLRR DKRMMVGEVL YGESSSSIGS NGKREPSYGP TAPAPFDNGN
LHKYAWPENS PHTVSQASPI IQKDHHQHSP VSASHYHDGR GIQSSAYQAQ HSRGPPGSEI
RQHVMNKTAA DLLFPTISNS HDALHLLSEA AGRTEDLNRQ RLENKARQSA GSYGAHMSAT
SSTMPRNPHH PYPKRSHQMS ADGYSDTSAD YRKQNFETYN DPGYLDAVKA WSRLRFVRAG
WLSVEEAMAY IAYYYKHLAP LSPIVIPDFS PPSTHRTLLT DEPVLAVTML TTASRYMKPK
GDGAHTRGYY IHDRLWAYLR GMIERLFWGQ EKFTGNSVGM GTPRSLDIPL PAQGQASLRG
HLRSLGTVEA LLILTDWHPR NLHFPPGDDE NTLLDADALL PSRNDGDSDS RGPSGGGVEG
RFAFQKWLEP TWRSDRMSWM LLSTAQALAF ELGVFDRKAP SALESVAEQV RKRRVRRLII
VYITQGSGRL GIPSMLPLDR WSDDIEPTTP ADATEAEIAI DRMQDLWVQI SKIMSLSNTD
LFPSKEYTSE LIKTGRYKQQ IAEFLPHLQK FRAYYDSVSL SPQMQNILTI EYEYTRIYVN
CLALQAVVER WTTINNEPSS KSSAASSLRV LMEIYRVNEK YIQEVVDASR KILHIVLDCL
VPDEQLKHCP TFTLGATEDD VRVSLDLQDR TIEALRTCVV DDVHLSNTIS RLLELLTANI
RTRFLRFAPT DRGADGDSHE RSSQPSSRVA SPRPTKDNNS TRRDSGAHWQ HQIPTPTHNK
LGYQFNQGAG ESQQQHPVGS HHDPLAGIPA QPINSSNIGV SFMPPPPSVY YNYYGANGPS
PPKLDDSNSI AQSVHEGGLP DWFALPLDQF FNSSATGVDQ GLGGTGPMLG EFDMLEVLLN
EQLDKDGNVG GPSAGNGVEN MDGAPTPRNQ HQHHPFM
//
