ID A0A093YDX9_9PEZI Unreviewed; 1136 AA.
AC A0A093YDX9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=V490_01131 {ECO:0000313|EMBL:KFY00938.1};
OS Pseudogymnoascus sp. VKM F-3557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFY00938.1, ECO:0000313|Proteomes:UP000029320};
RN [1] {ECO:0000313|EMBL:KFY00938.1, ECO:0000313|Proteomes:UP000029320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFY00938.1,
RC ECO:0000313|Proteomes:UP000029320};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY00938.1}.
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DR EMBL; JPJS01000321; KFY00938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093YDX9; -.
DR STRING; 1437433.A0A093YDX9; -.
DR HOGENOM; CLU_001524_2_1_1; -.
DR Proteomes; UP000029320; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000029320};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 699..929
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1136 AA; 128430 MW; B002DF79EB864E37 CRC64;
MLLPTRAGYS SRPCASFVRL AKLKARDETT HLSRGAVRRG FATDGAIPED HQTKNSSSLA
KTSNPRFNEI GVQQLSSHVH SQIFPGPSVT APKELVELSR DHLQRHELLG KNTDDNAPIS
FDLPQLQGET LDEHFYKLGT DAGEPYSGYA NQFTKANGPP KPRKWVHRSG WTKYYSDGRT
EAVDAPNEEM LCFDTEVMWK ESSFAVMACA VSPTAWYAWL SPWLLGESES DRHLIPLGDP
QKHRIIVGHN IGYDRARIAE EYSVTQSKNF FLDTMSLHVA VNGMCSRQRP TWMKHRKNRE
LRDKIAHETD NIELAALLGD RGLTEEEEEL WVGRSSVNSL RDVAKFHLDV TIDKAQRDSF
GELDRAGVRG KLDELLDYCA ADVSITHRVY KIVFPNFLAT CPHPVSFAAL RHLSSVILPV
DKSWESYIAN AEATYLKLSD SVQERLIALT EKALEIKGDE EKWSNDPWLR QLDWSGQEIK
MVKGKKKNDP PRPAARQKMP GMPAWYKGLF AKAGAPINLT VRTRIAPLLL RLAWDGHPLF
WSDKYGWTFR VPVAESQKYK DLQMQRCNEF DEKDIALRDD TGGVFYKIPH KDGPTARCAN
PMAKSYMSYF ERGILSSEYS YAKEALEMNA SCSYWISARD RIMSQMVVYD ADLQKPAKGQ
EGNDTGYILP QVIPMGTVTR RAVENTWLTA SNAKANRVGS ELKSMVKAPP GYCFVGADVD
SEELWIASLV GDAQFKLHGG NALGFMTLEG TKAAGTDLHS RTASILGITR NDAKVFNYGR
IYGAGLKFAS TLLRQFNPGL SEAETTKVAT ALYKETKGAK TNRKALHKRP FWRGGTESFV
FNKLEEFAEQ ERPRTPVLGA GITEALMSRF INKGGFMTSR INWAIQSSGV DYLHLLIISM
DYLIRLFNID ARLAITVHDE IRYLVREEDK YRAAMALQVS NVWTRAMFSQ QMGINDLPQS
CAYFSAIDID HVLRKEVDMD CITPSHLTKI PHGESMDIVQ LLAKGPLAEL DNSIKSTDAP
KLDGIKYTHR QPVMEALEKA NLSFLKAQIT ADENELKEIV KVQKKVLDAD EKTTKPRQTR
ARKILPYQAH AELMEEPLNI TDLLESNFRK DTRKKKQQNY PWEEQMPPRY KSIPRW
//
