ID A0A093YE05_9PEZI Unreviewed; 1735 AA.
AC A0A093YE05;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V490_01127 {ECO:0000313|EMBL:KFY00973.1};
OS Pseudogymnoascus sp. VKM F-3557.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1437433 {ECO:0000313|EMBL:KFY00973.1, ECO:0000313|Proteomes:UP000029320};
RN [1] {ECO:0000313|EMBL:KFY00973.1, ECO:0000313|Proteomes:UP000029320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3557 {ECO:0000313|EMBL:KFY00973.1,
RC ECO:0000313|Proteomes:UP000029320};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY00973.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJS01000317; KFY00973.1; -; Genomic_DNA.
DR STRING; 1437433.A0A093YE05; -.
DR HOGENOM; CLU_001083_2_0_1; -.
DR Proteomes; UP000029320; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029320}.
FT DOMAIN 925..1117
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1153..1324
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1390..1701
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1735 AA; 192200 MW; 54B07E2EDCBE8CC2 CRC64;
MSFRQNGQHR YGHVPPQQYG GQQPAQNVGL GLQRQSSFDN GDDAQFFDNA NGTRPPPAQP
NAYPQQSHYG SQRASGGGQD ELYLDGTGRG HRSPERQQYT PQPSQYTNQM YAGQPGGVPQ
TPSTPSTYNP QHFPRTQSQS QPHVTPSYTP QLYSSQSVSS HHQPYVPAAY QPQQPPVPPR
PPGQSPYMQG PSYGTSPMPQ HNQTFGGPPL AQNQQASPYW SPQIPQSQQY SAAPQLPARV
PSQPAYEPSY EPAYEPLYAP SLPAPLPPKP AQYSAPPATA SYPANGTTYG STNDYRAQST
PSPYPPVTQM PLGPSYEAAY DDFGPDAYGG RPSRPSSNSN PPPLEQDVQN VTSLRRHPTG
RPLPTAPAVE DTDPFDDDQD RLSAEARAQE LMFQEIEAAV GGNIASRSQI SQPHAPMSGD
LLDNEFGDLP GSNGLGADAR TPTAGQNSEQ MYEFEDSDEA EAVAGVEALR LANEADANRS
SIGAFGLYSQ QQQVPQETSQ GASSDSDNYA TGFDLSNLGG GPYVPMAYGN DIVSHAEMQD
ESRPLPSTLE MRSQERHAPV AVAGLGGLTD YSIPSDDIHH PFPDPVADIP SLPVHRRSFD
EGDERSSLGS RMTAGSRLSG RSGSDSPTRE EYADIPFDPG MAAASIYNRP LPAVPPLSEN
RTPQLRPAGS YRNPPTQQQD PQKTSQMYSP DGPESSTPLV VPPMRSRTDA EERQARQRAL
RGYTPALDGF DAGTPQSTVP LDLPALPPGR RKKATPENLR SSDYKKCREP WALSGIADWI
REMYCGESGD GDADLRVKSI QDLLVALFTH KVPTMNTADA EVISAVVVND MLQASVLVED
EEWVKFGPGE ISGVLWQMSG SGCYSPKVHE HEIHGRCYSH HCHRTLKKIN LHAQKMAPAK
RAEPWHEFFK LTKAQIDAAD SKEVLRQNNL HEIIMSEDKF MVQVDVLRTI YRDELQAWQP
PIIGQAKLPR FIQQVFGRAE AVKNVNMNHL LAQLKYRQQE EGPWVTGFSS IFREWKRRAH
QVYLDYAASY PNATYLVRRE MEKNVLFRQF LDQAQSNKVS DRLGWDTYLF APLKRLQQYT
LLLKEVLKHT YVDNEEKANL IIAIKEVDEM TKDCDEKVNE ENKKIEMQEL QAKLYMRPGF
KRVDLHLDHL GRQLIMQGDL QRPGTSRFNW LETRAILFDH YLVLAKAVSQ RDSAGLKNKE
VFDVSKEPIP MQLLTLESTN DEAVVKSKGL GSVTTVTRSA ASTSDSRISR ASTASDRPLL
DHASTSTSLS SMSKVSSNTT AEGDARSMFP FRIKHLGSQD VYTLYAPTAQ NRQEWCEKIM
LAKERHAASL FSQNAEPFRL KVLADTAFLM DPAQVGSRSA GLTVAGTPLD RAIKDIEREY
GHARVSPVCR AQVNCATAFN IYGKSMIAIG TDYGVFISEV NNPRGWTRSI QSSRITQIAI
LEDFSICLVI SDKALIAYHL DSVVPVSNFP APQHDSARRA PQKISGSREV TFFATARMKD
RTLVFYRGKG SLGNLSSSTF KVLEPVFQKS SEKKSKLFGR SKMGGGTTEF FREFDEFYIP
VECYGITLFH SYIAVCTQKG FELLTLDKKI TMSIPDPKQA NIAAIFDRLK NQMPLGMFRL
SDAEFLLCYE DCGVYVDKHG EVSRSVVLEF VGKAKSAAMY GAYLILFDTD FVEVRNAENG
RLRQIVAGKD VRCLDYGVQG ASTMARRSIK VAMAHPEMPN CQLVVELVLN EGQRE
//
