ID A0A093Z6T9_9PEZI Unreviewed; 1410 AA.
AC A0A093Z6T9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Dicer-like protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=V492_07751 {ECO:0000313|EMBL:KFY06775.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY06775.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY06775.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY06775.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY06775.1}.
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DR EMBL; JPJU01002698; KFY06775.1; -; Genomic_DNA.
DR STRING; 1420902.A0A093Z6T9; -.
DR HOGENOM; CLU_000907_4_6_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00657}.
FT DOMAIN 63..243
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 400..576
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 597..691
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 940..1085
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1130..1316
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1347..1409
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 554..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1410 AA; 158317 MW; C359F6D0A6C4EC9A CRC64;
MTTLRTSTRT SYYQRLHSNE AIMTSQEPTH VVLEDAPADF TGGELAKPTA IPSEQSRLYQ
LEMLEASMAR NTIVVMDTGS GKTHIAVMRI KAELESCPQH KRVWFLAPTV TLCEQQCATL
RANIPYVQTR LLVGSDNVDR WSEQRIWDTV LENIRIVVST HGVLADALSH GFVQIEELAL
LVFDEAHHCA REHPANKIMK NYYHPLLERK GPHAVPHILG LTASPVIRSK PSDLQIIEHN
LNALCRTPRI HRGELLEHVH PPTFVRLAYL SSPSEYGNYT SSALVSLIAM YSNAINSSMP
QTYDDDLVKK QAKTYRELKS FCTKASHIYD ELGQWAADYY IRTSIEIWNA AEMNRRADVF
SDNGNHNVLL EQLLHRIRSD NTASDSTRPD DTNTTRKVRQ LVRFLTSYKE GDLHGIIFVE
QRATVAVLHQ LLSLHPMTKG MIRSGTFIGT SNFSSRKSSL GDWLSPLEQM DTLDCFRKKN
KNFIIATSVL EEGIDISACN IVICFNRPPN LKSFIQRRGR ARKNRSIFVL LVASDDRSLG
LQEWGDMENQ MREEYQKDDS KRQKLQQLED EEEHVEGYSN SRFEIKSTGA LLTLEIAVAH
IHHFCATLPP QPYVDLLPKF YFRESPYGLV TGVVTLPNCV DASVRTAASC REWKSERMAK
KDAAFQAYVA LYKKGLVNDN LLPLLLEKDP EAIADIETRA AVEEVSQIYD PWVRVAKSWA
EAGQSLRRRL ISISRPGRST LHLVIVVPQE LPALETFTVY WDNQTTYSVS ICEITSTSTT
DTASLSTMRQ VTSTIFQAVH SNRMPAESND FLALFIPNIE EGLLQSWLEE SAGNFPATEL
LNAEHNSSYG LIRDQARYAS PHVFKEAAAN GTIKVVRLPK RRDFLHRSVA IKQDDAEDLD
CSERPDLFLP LESSTIDRLP MDYVECSLLI PSILHRLWRQ ALGLELHSTV FENQGFLNLD
YLITATNAPS ANEDSNYQRL EFIGDSVLKY LVCLNLYANN PSWPEGYLSR AKDQDVSNSR
LSRAALTVGL DRYIVTKTFT ARKWSPPYIK YVLEAESSSE KRVLSTKVLA DVVEALIGGA
FLDRGFEAAV NCISRFLPGR PIAAPLRIFA GGTDAEERVF APTSLASGHL SDVERLIGYQ
FKNRCYLLEA ITHPSCEHDA HTSSYQRLEF LGDSTLDMIV VSFMIDNAPH LSHGMMHLTK
TAVVNAGFLA YLCLDASLEQ HVTDVSFGPD YNLDDLMEVR SSKLVHLCQL MRYQHPEINT
AMSSCLERYY KLKPAIASAI KNGNEYPWVL LASLAPAKFL SDIVESIIGA VLIDAGGDLS
ACTKVAEHLG LIDYLRRILD DDIDILHPKN KLGEMSLDRT VEYKPGKEGE GYTCTVEVGG
ATIVTVSNGI SQEEAVTRAA YMATEILDND
//
