ID A0A093Z8H0_9PEZI Unreviewed; 2174 AA.
AC A0A093Z8H0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Carrier domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V492_03137 {ECO:0000313|EMBL:KFY13636.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY13636.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY13636.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY13636.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY13636.1}.
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DR EMBL; JPJU01000971; KFY13636.1; -; Genomic_DNA.
DR STRING; 1420902.A0A093Z8H0; -.
DR HOGENOM; CLU_000022_6_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 381..813
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1657..1738
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1796..1873
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1742..1790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1742..1784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2174 AA; 236286 MW; F9C5DADD9195642D CRC64;
MVEKISFLLF GEQSLDTQGF LADFCCNGNP SVLSHAFLDR VASTLQNETE RLPSLERRHI
PPFTTIQELN QRYHAKDITH SAIDSALLVA TQLAHYIDRA EKVPEDATRP QETWTVGLCT
GLFAAVAVSI APSLSALVNI GAEFVRLAFR TGRHVSTLAE QIHESGDSIK SWTYVVPGLG
ESAARSLLAD FNGSKGYTTT TQAYISAITS TSVAFSGPPP TLKALVDEHE FKAEPLPLPI
YGPYHASHLH SADEIEIVLR LNDPNLSEVL KNASPRFPVI SCSTGHWLTE KDPKKLITTV
IRDILQEPLN FQRVLASCVT QAHNYQSSSC LVIPFGPTHA ANSLVQLLKN ETDLEVHLRR
APHSKKDRIA SHTGDHGSSK KCKLAIVGMA GRFPDAATHE KLWEQLEKGL VLHREVPADR
FDVKTHCDPS GKVMNSSHTP YGAWIENPGL FDPRFFNMSP REAHQTDPMQ RMAITTAYEA
LEMSGYVPNR TRSTKLDRVG TFYGQTSDDW REINAAQEVD TYFITGGVRA FGPGRINYHF
GFSGPSFNID TACSSSMAAI QLACTSLWAK DCDTAVVGGL SCMTNSDIFA GLSRGQFLSK
NGPCATFDND ADGYCRADAC ATVIIKRLDD AIADKDNVLG VVLGTATNHS ADAVSITHPH
AGTQEILYRQ ILNMAGVNPW DVDYVEMHGT GTQAGDATEM KSVTNVFAPA DLKRSAEQSL
YLGSVKANVG HGEAASGVTA LIKVLMMLQK NTVPPHVGIK KTINRTFPKD LAERNVHIAY
HSTPLVKKNG QSRRVFVNNF SAAGGNSGLL LEDGPATTTL SKDERSTHIV SITAKSKSAL
LNNAERLMYY IEQHPEASLA DISYTTTARR IQHNWRVAVT GFNITQVREF IKHKLTENIT
PIPQTTREIA FLFTGQGSHY AALGKELFEN SSLFKETMLE FNNIAATHCL PSFLPLIDGS
TVAMTDLSPV VVQLGLLCFE MTMARLWASW GINPSVVVGH SLGEYAALNI AGIISASDAI
YLVGKRAQLL MEKCTVGSHG LLAVKASVSS IRESVNGTSI NIACINGPEE TVLSGDIALI
DAISERLAAA GFKCMQLKVP FAFHSAQVDP ILDEFEKLAA SVQFHSPTVP TVSTLLGRQL
REKETVNPSY LRRHAREPVN FLGGIISIQS AGLVDEQTLF LEVGPHPVCI GMVKSTLGKE
TVAVPSMRRA ESAYKTLSDS LSTLHTAGFN IDWNEYHRDH LDCVRLLDLP TYAFDEKNYW
LQYTGDWCLT KGRASNSQVA LQQDLKPKIS TTTVHKVVEE LVDGDVATIS TESDLARADL
RSAVMGHLVN GAGLCPSSIY ADMAMTVCEY AYKLVRPDVE NIGINVASME VIKPLIARPD
GTSQILKLTA TIDASRSSAK LIFSSGSDKV RVDHAHCVVT FGDCATWLLE WERIAYLIQH
RIDSLKNAEK NGKASKIGRG LAYKLFAALV DYDAKYRGME EVILCSENME ATSHVSFQTK
PTDGTFVCSP YWIDSVAHIS GFIVNGSDAV DSGNQVYVSH GWDSLRIAEP LSADKTYRSY
VKMQPAGGKM LAGDVYVFDG SRIVAVVGGL KFQCILRAVL NTLLPPAGVT TPGPAPARAP
VAQSSPAVAI QTTSALHKTT TTTTKINTAQ DRMTNLEPGS KKLATVCSQT MDILAKEVGV
GMDELVDNIA FADLGVDSLM SLTISGIMRE ELEIDVPPSI FLEFPTIGQF KTSLARFETA
DSDISEGTES PVLYVNTDDC TPSTDDSTPN TDSSTPTINE ISPLSTPPDD LELELNKDNN
PWEIIRNTIA SEVGATTEEV TDAQDLALLG VDSLMALSIL GKLREETDLS LPADLFVTCT
SIKDIERALG VGQRPKPVRM NDATSFPKLS SQPISTETVV LKESGHQLTD ITPERFATSV
LLQGKIRTAT SHLWMVPDGS GSATSYADIP EISPTLAVWG LNSPYMKASE EFTCGVPGVA
AKYIQELKRR QPIGPYMLSG WSAGGVIAFE MLNQLVKAGD EVTHMIMIDA PCPLIIEALP
SSLHRWFASI GLLGDGDPNK LPSWLLPHFA ATVAALSAYD AVSIPKDKTP SVTAIWCEDG
VCKTESDPRP DPYPEGHALF LLDNRTDFGP NLWDSFLPAE KIRCVRMPGN HFTMMGGDLV
KKLGGIIREA IAMT
//
