ID A0A093Z970_9PEZI Unreviewed; 4098 AA.
AC A0A093Z970;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Elongation factor 2 {ECO:0000256|ARBA:ARBA00017891};
GN ORFNames=V492_06971 {ECO:0000313|EMBL:KFY07625.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY07625.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY07625.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY07625.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY07625.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJU01002508; KFY07625.1; -; Genomic_DNA.
DR STRING; 1420902.A0A093Z970; -.
DR HOGENOM; CLU_000126_0_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006113; P:fermentation; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR CDD; cd03700; EF2_snRNP_like_II; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR047104; BLTP1_N.
DR InterPro; IPR029636; Csf1.
DR InterPro; IPR048636; Csf1_mid_RBG.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR32085; PROTEIN CSF1; 1.
DR PANTHER; PTHR32085:SF3; PROTEIN CSF1; 1.
DR Pfam; PF20413; BLTP1_N; 1.
DR Pfam; PF21678; Csf1_mid_RBG; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3271..3509
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 124..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2573..2596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2927..2954
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4098 AA; 453468 MW; D53830C54E618F5B CRC64;
MSSSGGLTAV SLTPVLGFNW VFLVELIVCG ILTLFFLFYF NRLFATIVSY GIRAWSWHKY
RVYVDIQALQ ISLLGGRIFF KGLRYHGNNE TILVHSGFIT WAYWRRNVRE LDLSHGKDLH
SVASESTAKN DKENYKDQSA TESGAKAAKS TLPCRLNVEI KGLEWFIYNR SAAYDSIVAG
LAKSDEIKQE STLVDDPTGK EHDTGLKKRG FPKPAVLASI LNKHSSETDG SSGLPPLTEK
DTNRESLGTT GSLHSEDSSN ACNGQANQET EKSFILNLLP LHIDCVKAAV VMGNDNTKSV
FITKADKFSG DINATACRAP DLYKQVFDLQ FVHPMIQLKP NEDYNEDQTT TANRAKDDIK
ERTDGVEGVL HPSRLFHRYR RKAWHKLQNI VPYFSSSVET FSSSTPEPVI SDTNTQGNLH
QWQGLSRYLN DEEDGKAKWS SFEYATVSTI LDSPEASVSY YWDIPGKVPM EMGSPKTQPW
QTSDINGDMP PEWGIDVIIK GALINYGPWA DRQRADLQRA FFPSLCKDAA PADNLKPGDT
RVATNLKIYI QLDDDTTLRV PIREESKNWK WKSQADTMTS QMQEQNKRTG KSSRKHKAKG
DHAGPEIRPF GWLDLKICKN ATVNYNMDMV AGASGFSNTL DVDFPNLEIT TSVNHGILCR
SLNQRLSCNL SNPLGWNAFH TWKFDFISNG MELFILREHI FLFIDLIDDW TTGPPPDYLT
FTPFHYLLKL QFGDFKLYLN VNDSNIINNP SDLDDNAFLI LDGTGLVADL CIPLDKYRPH
RNNVPFDLAV DRANLVLHVP PWNTQATFMP SNEIAQVEGV SIKGKYQYCD TTSSSNTDTL
MVDVSGRNLE VQLFGFLIRY FMKIKDNYFG EDIHFRTLEE YQQIINAKDP GTEALLNKPP
PKKSNDLDVI ISIGCKTNGA LLPANLYSAK DHVRVEIATL SADLRFTNYY MDLNVSLSPL
VFSQGTQEGL STPMTSVSGS QLFVDGVEIF GNRLFGLPPT EPTYLCNWDF SVGSVRGETS
AEFLMKLSAA VKAFAFSFDD DENALPPITP EILHDATFLR ASVEHVHVWA HVDDAAFLLS
TGPVRVSFND LAGQLYSKKL NVTIPDLALG CVDADSASRH RSRASHPVET HAYITTTIEF
TMVNRKAGFE DDKRLQQAHI RHEDSRTHRT QFLLVDDPFR PPPIQVDTPA MCFPPVPLPV
NNGNNYHPNR AASSIASSQN AKQYLRRKSS FLSLTSSERS SQKSIIRTHN SLSDPRVQYN
SSDSPSRSRQ LGDSLRLTPL PRDISAASTG RQPSFYSAVD HNDLRARTSS SVIFSSPFIS
PYFPLDEIEP DMGNLPELGE HDLDQAPTPS AEMKPADKIF DDNTEYTSFI VEFKQGIRAV
SNPQAIKAVT RFLEVLQPTS AEDIIDSVQI ESMNDIFAAK KKIVVAGKNT DVNIVLPIIR
LRFANTAVSE YHQRSDQPLD QYDFSARGMS VIGRQRSAAK ENVDRSKSNE ASAVRVRVLS
AEVSAKERSH GRADAQAAIN GRVDDISFWM ASDKTVSGHL NIKAIDVEMA SSKVKYLASL
LHRTTHMASE AGDGFASLAR WQTNRIRHSV FLLSTQGQRT SDPLFMTRPS YVLRSAADHL
RTTDSWKLIT RLRHVYSTLG YNERQRIEML LSERDSASYP EDIREQVQAG FEKWRSWDLE
NLTECVLMTK VFGSLIRDDT APPEIQKPTQ FRAAITRTSF VLDPGPKQNE IALITLAANV
SMSQVNADDT SDQAPIQDAC TIVQIYCMDS SITLNWELCE LIEVTTKLYN ETQAAPAPGQ
PAPAVRPPTT TQINKPKQSL HLIFASDNGS VTLDTINIRA RSLSTGLKVS LLVADGLCDG
RSIVTALVTA DAATSKFRSH HQDLAIHQFL APTLNVSRES RVVGKIKENA WKVAGNSQEL
SFVVKQDVVA LLQVLDHIVG DEVHQISQIL RSLPKKPVQR SVKCRVPSTA AINKINIALF
LDEYHISIPL LNSVRYDISG VVARASLAAR QGVEFVFDFD IKENSHDIRT EATGKSQTIS
VLQLPPTNGR VIAQISEDEH KFSVFVSVEP IFLDAAKIQN VVAALNRPEM TNMMDEAREG
FRTLTSHIPE GIDPGKVPAK QEVAKDTPSP FIYDAHLSMA GLEVFTDAPN GNYNDNKARL
TFNLGIVQVE AHNRLAMAGP ALQFPELQLN LRRVVADLAS ISNTGKGESC GNFAFAAKFT
AGSKETDDGG QVRSYHLTSD SLEINLFADT ASTIVNVVGH LQTKIKELEL PRDVNYFQRF
RNPRITVEED VGTPESTAAS LNLFDAMFSL ELSNLQVSWI VTAPYLDQAE GREDLVLSLQ
RIGLSTRKKK SARLSIENLM LQMVPPDQVK NVRSQNSALL PEVVFNIGLV STATATRLAF
QAAGKSLDLR LTSQFITPGS NIQKSIASAV EKARSASASW MTSPASDKPS DTAKNIFFGK
KNMESLLVDA DFAGAVVHLQ GMKTSDSAMS SLPDKRSRVP QGGRYGQFAQ DEATSSTMLR
SPGLAIKVEY KDNGTDDPSL NAEVKVNASK NILYPQVVPL IMEISSNVQA VMSNNNEPEG
ASDKKPPPQK PMGAADDNIL TVDPSAVLGR TRLNLGIRIC AQEFGLSCQP IARVAATARL
DDIYITMNTV RSVDHGHFFA LSASINHLQA SVQHVYSRES TGSFDVDSIV LSMMNSKHVS
GTSGLSAILK VSPMRVLVNA KQIQDFLLFR DIWMPTDLDR GPAPAPVPQQ ERTSQAQTYL
VQRYQQVAAT AAFPWNATIS IEELDVQLDL GQAIGKSTFV ISGFWVSSKK SSDWEQNLCL
GFEKVGIDST GRMSGFTSLQ NFRIRTSIQW PEREKALNQT PLVQGAVSFS HFRLKVAFDY
QAFLVADITS IQLMLHNVRN GPSAAGDRLV SMLDGDSVQI FCTTTSASQA LALYQALEKL
MQEKKSNYES SLKEIERFIR RRPSTFPVAE IAEATPPPQE ELTKAPITLH TDVVVTLKEV
NMGAYPSTFF DAQIFKIEAL NAEFRFAVTV PAGIVHSRLG LTLGQLRIGL AGVKSPGQPK
STGELSVEEV VSSATGSRGG TILKVPRVEA TMETWQSAGS NQIDYIFKSS FEGKVEVGWN
YSRISYIRGM YGNHAKSLAQ RLGKPLPPSA VKITGVPEAD EDGKERATGE QQKITAEVTV
PQSKYEYVAL EPPIIETPQL REMGEATPPL EWIGLQRDRL PNLTHQILIV TLLELAGEVE
DAYAKILGSS STAIMVNFTV EEVRTLMDKP TNVRNMSVIA HVDHGKSTLT DSLLSKAGII
SSAKAGEARA TDTRADEQER GITIKSTAIS LYGKLTDPED IKDIIGQKTD GGDFLINLID
SPGHVDFSSE VTAALRVTDG ALVVVDTIEG VCVQTETVLR QALGERIKPV VIINKVDRAL
LELQIEKEDL YQSFSRTIES VNVVISTYFD KSLGDVQVYP YKGTVAFGSG LHGWAFTVRQ
FAQRYAKKFG VDRVKMMERL WGDNYFNPHT KKWTNKGTHE GKPLERAFNQ FILDPIFRIF
NAVMNFKKDE INTLLEKLSI KLTSDDRDKE GKQLLKIVMR TFLPAADAML EMMILHLPSP
VTAQNYRAET LYEGPPDDEA CLGIKNCDPK GPLMLYVSKM VPTSDKGRFY AFGRVFSGTV
KSGLKVRIQG PNYVPGKKDD LFIKAIQRTV LMMGGKVDPI DDVPAGNILG LVGIDQFLLK
SGTLTTSDTA HNLKVMKFSV SPVVRRSVEV KNAQDLPKLV EGLKRLSKSD PCVLTYISES
GEHVVAGAGE LHLEICLKDL EEDHAGVPLR ISDPVVAYRE TVTTQSSITA LSKSPNKHNR
IYMIAEPLSE EVSNLIENGK ITPRDDIKTR ARLLADEHGW DVTDARKIWC FGPDTNGANL
LVDQSKAVQY LLEIKDSVVS GFQWASREGP VAEEPMRSIR FNIMDVTLHA DAIHRGGGQI
IPTARRVLLA STLLASPGLL EPVFLCEIQV PESAMGGVYG VLTRRRGHVF AEEQRPGTPL
FTIKSYLPVN ESFGFNADLR SHTSGQAFPQ SVFDHWQILP GGDPLDPTSK VGGIVTEMRK
RKGIKAEVPG VENFYDKL
//
