ID A0A093Z9M7_9PEZI Unreviewed; 1665 AA.
AC A0A093Z9M7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V492_02897 {ECO:0000313|EMBL:KFY14031.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY14031.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY14031.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY14031.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY14031.1}.
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DR EMBL; JPJU01000883; KFY14031.1; -; Genomic_DNA.
DR STRING; 1420902.A0A093Z9M7; -.
DR HOGENOM; CLU_000972_1_1_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 8.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 7.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT DOMAIN 277..383
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1027..1243
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 190036 MW; BBB5337AD600D1CC CRC64;
MSYRHPLQQI QANDYSSQLA KRQPSTASTS SSAYSHPSEA SYLSRTSTIS STASSGYQQP
AHKRGLSEVK GMAPTADPRP GSSGRGFSTP NSEDPFQSVR LSLRPLPQVP AQTCPSPPSK
QLFQHSRGQS LDVKPMYNDV SASPPPKRTA ALRPNSMLLS RADSTRTVRS NSMQPSSQLS
PLHTPVAAPD LQSLGKSSTG HLRTLSKFAE VSSPNEFAIS SPAQEVAGLH GRRRLQRTDK
TANGGSAVAL SNGTGYGWEG RNWMDKQRQF LQAYEYLCHI GEAKEWIEDI IHRPIPPIVQ
LEEALRDGVT LAEIVEALQP DNRFRIFRNP KLQYRHSDNI AIFFRFLGEI ELPDLFRFEL
IDLYEKKNIP KVIYCIHALS WLLYRQGVVD FRIGNLVGQL EFEHHELEAM QKGLDKAGVS
MPSFGNMGAD FGVPEPEPEP VESEEDRIDR ELHENEPAVI DLQAQIRGAL ERMRLANTME
KLWNSEDWLV DLQSRIRGDF SRQIIDYRLS MRRFAVNLQS ASRGFILRKQ LMNRTEFFKN
SEAEILKLQS LFRARKVRAE VCITKSQLKN ESFAVRDVQA AVRGFLMRKR MEQQHKETRS
MATPVRGLQA SIRGMLLRAT IANDHHILDA ETASIALIQA NARAMLTRIQ VSRQKQALQA
STGIWKALQA MSRGHLLRNQ IAYTRKELKA QSPSIAMFQA AIRASAVRSE TARILAALET
EEPTITDVQS LARGMISRQR IAAQREALNR QAANITKLQG CARGFLFRAA NADLRADLYS
NSPAIIQLQG LIRAMLHRNV IGTLLGELED EEDSVVAFQT AARGLLVRAK FAEKQKFFKE
NMQKVIKIQS FVRGRLQGEA YKSLTTGKNP PVNTVKNFVH LLNDSDFDFN EEIEFERLRK
TVVQQVRQNE TSEQYIEQLD IKIALLVKNK ITLDDVMQHQ RNFGSHASNL LPSTAMSSGN
HFDLKALNKN SRKKLDTYQQ LFFTLQTQPQ YLARLFRMVR EQGMAEQESK RVETLMMGLF
GYAQKRREEY YLLKLIARSV KEEVDGAHSI QDYLRGNFFW TKLLSNYTRS PRDRKFLREL
LGPLIRENII DDPALDLESD PMQIYRSAIN NEELRTGRPS HRPLDVSREV AIKDKETRDL
FIDHLRDLRE ISDQFLLALE ETLSKMPYGI RFITQQLFEC LCERFPGEKQ AYILQVVGQW
VFRSYIQPPL TSPQEVGVVE RQLTPLQKRN LGEVSKVLCQ VTTGKLFGGD NIYLQPLNAY
VGTAIERMGI IFADLIDVPD VEQTFDIDEF NDLYSKTKPT LYIKMADIFA IHNLVIKELP
QICPNRDDML REIIQELGSA KNNEIEWSGV TSSEIQMTLN PKLHDSDDPE AEVKALFMET
KRCVLYIIRV QSGPNLMDIL VRPITREDDQ KWRALVREEF AAGSNTRGAY SDANMMDITS
MPYSELKRTA LENIMRLETQ FGRISRHNQY QDLLNAIAVD IRTKSRRRIQ RQRELEGVRL
TLGNLHDKAA WLEQQRKSYD NYIEQAMMTL QNKKGKKRFL LPFTRQYNHE RELQRTGRQP
KFGSFKYSAR NLADKGVLVS WAGYTEKQYE KINVTISCDE VGIFFIEGSL GSIQIPGASA
QVPLEDCLSA QFNNHQFMNL FEGGLKLNVN LFLHLIYKKF YRSTD
//
