ID A0A093ZN44_9PEZI Unreviewed; 720 AA.
AC A0A093ZN44;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=V493_08541 {ECO:0000313|EMBL:KFY18534.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY18534.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY18534.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent DNA helicase important for chromosome
CC transmission and normal cell cycle progression in G(2)/M (By
CC similarity). May have a role in changing DNA topology to allow the
CC loading of proteins involved in maintaining sister chromatid cohesion
CC in the vicinity of the centromeres (By similarity). Has a specific role
CC in chromosome segregation during meiosis II.
CC {ECO:0000256|ARBA:ARBA00025396}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY18534.1}.
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DR EMBL; JPJV01003764; KFY18534.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093ZN44; -.
DR STRING; 1420906.A0A093ZN44; -.
DR HOGENOM; CLU_011312_1_0_1; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327}.
FT DOMAIN 1..209
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT COILED 180..225
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 720 AA; 82333 MW; 09D08B1B67FEA88D CRC64;
MSEIEKALAE LKALMNYRSE QLGRVEEFRG LGLTSRKNLC LHPSVKREKS GAIVDARCRS
LTAGFVKEKK EKGEDVELCT YHENLDLLEP HDLIPNGVWT LDGIMRYGEE HKQCPYFTSR
RMMSFCNVII YSYHYLLDPK IAERVSKELS KDCIVVFDEA HNIDNVCIES LSTDITEDSL
RKATRGAQNL ETKISEMKDT DAEKLQNEYA KLVEGLREAD EAREEDAFMS NPALPDDLLK
EAVPGNIRRA EHFVAFLKRF VEYLKTRMRV RQVISETPLS FLAHLKETTF IERKPLRFCA
ERLTSLVRTL ELTNIEDYQP LQEVATFATL VATYEKGFLL ILEPYESDTA EVPNPVLHFT
CLDAAIAIKP VFDRFSSVII TSGTLSPLEM YPKMLNFTTV VQETYQMTLA RRSFLPMIVT
RGSDQVAISS GFQVRNEPSV VRNYGNLLTE FSKITPDGMV VFFPSYLYME SIISMWQGMG
ILDEVWKYKL ILVETPDAQE TSLALETYRT ACCNGRGAIL LCVARGKVSE GIDFDHQYGR
TVLCIGVPFQ YTESRILKAR LEFLRETYRI RENDFLSFDA MRHASQCLGR VLRGKDDYGI
MVLADRRFMK KRAQLPSWIN SAVMDSDTNL SIDMAVSSAK KFLKNIAQPF KQEDHEGIST
WSVADLQKHQ EKEDEEKIRQ LRDGAALEDI RHGNEQDVIM GDEYGMDDEE FEAGMMELDG
//