ID A0A093ZNG8_9PEZI Unreviewed; 1906 AA.
AC A0A093ZNG8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=V493_08296 {ECO:0000313|EMBL:KFY18856.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY18856.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY18856.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY18856.1}.
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DR EMBL; JPJV01003717; KFY18856.1; -; Genomic_DNA.
DR STRING; 1420906.A0A093ZNG8; -.
DR HOGENOM; CLU_000893_1_0_1; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1383..1557
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1630..1906
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1906 AA; 212741 MW; 1CD43A8AC821B37F CRC64;
MDTRARGIRR KALQKIAALS VTSGKSQGNP DLERLYNIFP SRSNSKAGLN GYADEDNSVP
LGGVAMNIRE FEVLLALCKA APLLQDYQSA ERLAAQLAPY TLEAHTQIFV TSPFFREIEP
SPIESLNFNL TSALLSLGIN HPGLQNAISN NFTAYLERCQ YTARAVISRQ GFAAGKEDIG
DVEDAINVAR VAIALLGFLD AATIQANFWT AGERLALITV VKRVLSEDFL VAVETAFSRI
RNYHSTNREV KEWKRHVRHY AATGRPLGAM LLQRSFMWLL VATSSLLITD TKTLRDNCIL
ELMMGDTVPR PLTSHTAEDS LTSIDTMAEF ATEEMNKLED GADYLRIGSA WQQRIAFAVK
AGALTCYLNC VTLNDDVADA ESLMVWLEET LSDPIQMADQ TLANVVLRSM ALVAQICPSL
APNMSRILPR FIVQGSPRGD TVAVASTCLA FVLRLLSEDA VITTLYSLGN VLTPITSTER
VVATQARGET ANGHSSNPAF YGLKQTGSAI SLAAAGELEI AVAYGNVIKS IRVIAESCAD
DKITALAQSM LLQKITKIDT AVDAAIIYEA AVLASTGSPV ELKSLLKLYS RLTQEALLDE
DESMLAALLK TRNYLSSTLK KGSSAYDIYF EYLLETIVSR GDVYQLHHTR ESDVESAARE
IGTLVQPLAL LMSANNLGED ETTDDDIWAL VRDAWFNMVV HGFTTCTERG RQYLDELRIL
AVNSKPLVTE QRGEQLESDI ELNSVLRRGM NSEHEAIQKK RLTSLIPSKA GEIRSLSYRK
TIFLHTAYLV ETLRADSGDC TKAMIYFLEP GMRTGNMSSV MEAITMSVVD TYLRKAMLGV
NPTFSAPCVA EQLVSIFCGC CHRIERVQQA AIACADKILV NVTSALCQRS SLFALLELLS
LMWISCLEAE TDEYEWKSSY TSARSNVTIQ LGDNFEFRGR TLNTIYKKAK VWVMNVINIA
PLDIKGLLQT YLSEYDDDGA YGHISLGRSF AAEMGGMIPV TDQRLGAIDR HGDAKINAVS
DFVAQYTTRQ EYRYAEGLPD YDAEWANFMK VASSRSSILV EGLGTEHADA LTVLNFLDAR
MRKGKFIPIS ELRDMLRRAA AFLCRAKGDE AAVVKHLVGI PFVHFSKQSI KLGISLWQGV
INENPRMGSR IIMEIAQQWE NTIHMKKGVF NDEFKHPDPF FIRKEYAPSD KDTLHKKQQH
AQNLLAPHSR LLQFLASHFN ATRLCSPHTQ KTFVRLLQAT LNGLMHSTGH PLSRELRFNI
VMLSLKVLRH GTVLTAAAQY RLKNQMLSAA LSWFSFAPCF TFGGNRLQLK AEAKLLSDVA
AGLDSVRHIG AKNPTTLKRL MDKEELLFVL LENEQSRLRV WLDPFAEGKA SQHAEPSEAM
LAGLVKTAWF VSSSLAISLV TRFHSARVHT DVRKLLLADP LRGIDDPEGL NILMGREFQS
DLTWQLKYLL FWVPVNPITA VTYFLPSFSD NPFIIQYAMR ALESHSVEVA FFYVPQIVQS
LRYDTLGYVE RYIVETAQFS QLFAHQIIWN MKANSYKDED SQFPDDIKPT LDHVMSRMIG
CFTGPDRDFY EREFRFFDEV TSISGKLKPF IKRPKPEKKQ KIEEELRKIK VDVGVYLPIN
PDGVVIGIDR KSGKPLQSHA KAPYMATFRV KKDIGAEMED TEDMLEAADP RKRVPENSIE
VWQSVIFKVG DDCRQDVLAL QMIAAFRGIF SNVGLDVYVF PYRVTATAPG CGIIEVLPNS
VSRDMLGREA VNGLYDYFVS KYGTPDSVRF QAARSNFVKS LAAYSIISFL LQFKDRHNGN
IMLDDAGHLI HIDFGFCFDI APGGVRFERA PFKLTAEMVA VMGGSSNTQS YRWFEELCVK
AFLAARRHWA TMLQAGEHQA LPRAIRAGEE RARRRDICAE PSAEEP
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