ID A0A093ZQX2_9PEZI Unreviewed; 1095 AA.
AC A0A093ZQX2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
DE Flags: Fragment;
GN ORFNames=V492_03259 {ECO:0000313|EMBL:KFY13440.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY13440.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY13440.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY13440.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY13440.1}.
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DR EMBL; JPJU01001007; KFY13440.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093ZQX2; -.
DR STRING; 1420902.A0A093ZQX2; -.
DR HOGENOM; CLU_002472_0_0_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299}.
FT DOMAIN 978..994
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1095
FT /evidence="ECO:0000313|EMBL:KFY13440.1"
SQ SEQUENCE 1095 AA; 120273 MW; 50D05FCDAA0DB2FD CRC64;
MAPPNGKGAE KQRSIASFFT PKSTVNGLSQ KSPSQATPSS TPSATPVSNG LGNSKDADSD
EDIVAPTRRA VSTATKRKSP LDEDTDAVNV GSDRSAKRTK SGGNDTQSSF FEGNTSNQSP
RQLENKPTLS GRTEKYLYSG TQSQEAFESA EPEGDAILRQ KQLLHDKFVK KLGHPDSIAQ
IKRRNWQITE ETAALDDEDA EAAEDEEPAP RPKGAKKGAK SKLTPMEIQF LDIKRKHLDA
ILIVEVGYKF KFFGEDARVA AKELGIVCIP GKFRFDEHPS EAHLDKFASA SIPVHRLPVH
AKRLVAAGHK VGVVRQIETA ALKKAGDNRN TPFVRKLTNL YTKGTYIDDT EGLGDATAGT
PGGAPATGYL LCITETKSKG WGTDEKVDVG ILAVQPGTGD VIYDSFEDGF MRSEIETRLL
HISPCEFLIV GELTKATEKL VQHLSSSSTN VFGDKIRIER VEKEKTIAAE SYAHVAQFYA
RNIKAHGNST DERSTNLLDK VLKLPESVTI CLSSMIKHMS EYGLEHVFDL TKYFQSFGAR
SNMLLNGNTL TSLEIYHNQT DHAEKGSLFW TLDKTQTRFG KRLLRKWVGR PLIDKERLEE
RVAAVEELRD GNQAVQVDKL KSLLMKVKSD LERSLIRIYY GKCTRPELFT VLQTMQRISN
EFAHVKSPAD AGFKSSLLND AVAALPTIGD AITDFLEKIN AEAARNDDKY AFFLESEETE
DIGDHKLGIA SVEHDLDEHR PIAASKIRKT NVRYVTSAGI EFLIEVDNTN LKHVPASWVK
VSGTKKLSRF HTPEVIKMIR ERDQHKEALA AACDAAFSNL LSDIAAHYQA FRDCVASLAT
LDCLLSLATV ASQPGYVKPE YTGDTEIAVV GGRHPMAEQL LLDSYVPNDT SLSADGTRAL
LITGPNMGGK SSYVRHVALI CIMAQIGSYV PAESARLGML DAVFTRMGAF DNMLAGESTF
MVELSETADI LKQATPRSLV ILDELGRGTS THDGVAIAQA VLDYVVRDLQ CLTLFITHYQ
TLAGVARAFG SGELRNVHMK FTEQGRVGDE DITFLFQIGE GVAHRSYGLN VARLARIPRG
VLEVAREKSG MMEEE
//
