ID A0A094AGG2_9PEZI Unreviewed; 681 AA.
AC A0A094AGG2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 33.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=V493_02911 {ECO:0000313|EMBL:KFY28479.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY28479.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY28479.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY28479.1}.
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DR EMBL; JPJV01001098; KFY28479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094AGG2; -.
DR STRING; 1420906.A0A094AGG2; -.
DR HOGENOM; CLU_013809_0_1_1; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 219..412
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 529..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..615
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 72722 MW; C977E566A536BCF3 CRC64;
MASTTTTTAP PPQFAFRTLK EIGLTDAAPL YAPVPGFTRP QGNSRCCIYS PCGRYFAWAA
VEGVHVVDSA TGAPVAELPV PNVYELAFSP RGSYVITWER PSKDEAGDAV KNLKVWRTVE
EGERTVLGRW VQKSQTGWNL QYTADEKYCA RTVTNEVQFY ESHELGVPWN RLRVEGVADF
ALSPGNNNSV AVFIPQRKGQ PAAVKVFNVP QFGTAVSQKT FFKGDKVQLK WNALGTTLIV
LAQTEVDKTG KSYYGETTLY VLSANGGFDS RITLDKEGPI HDVAWSPNSR EFGVVYGYTP
AKTTIFNTRA VATHSFPLGP RNTMLFSPTG RFVLVAGFGN LAGQVDVYDL SKDYRKLTTI
ESGNPSVCEW SPDERFILTA TTSPRLRVDN GIRVYHVAGS IVYNEDMVEL YHAAWRPSIP
GPSTVSNPLA PVPQHSSAAQ YLTTVKTPSK PAGAYRPPGA RGTSTPLHFK REDEGGAAHT
VSNGTSLVSA PVFGHQGPRA RRAVPGAELV EVPAAATVED ENLSKAALKN KKKREAKKAK
EAEIKAGGGA PAVPPGFEGV AAAGAQRANG TANGNANGNR NAGRNTPAAA AAPPSTPARR
AAPAAPEPAP PAPVVAEEVL SPGGGSAHAK KLRGLQKKMR AIEELEMRLA GGERLEDTQM
RKIGTKASVV KELEGLEAGG V
//