ID A0A094AVB9_9PEZI Unreviewed; 721 AA.
AC A0A094AVB9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=V493_01243 {ECO:0000313|EMBL:KFY31288.1};
OS Pseudogymnoascus sp. VKM F-4281 (FW-2241).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420906 {ECO:0000313|EMBL:KFY31288.1, ECO:0000313|Proteomes:UP000029327};
RN [1] {ECO:0000313|EMBL:KFY31288.1, ECO:0000313|Proteomes:UP000029327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4281 (FW-2241) {ECO:0000313|Proteomes:UP000029327};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY31288.1}.
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DR EMBL; JPJV01000446; KFY31288.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094AVB9; -.
DR STRING; 1420906.A0A094AVB9; -.
DR HOGENOM; CLU_008878_3_1_1; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000029327; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000029327};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 264..477
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 550..701
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 650
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 721 AA; 78042 MW; 80A60248D78B9788 CRC64;
MSTPLGPLST PLPPLPDDIF TSAQWSILLA LMDAVVPRIV RASAASPSRA IDELVISEEE
YGAIARATGN EEGETLDAYL AERPSESEEF KGLLRRQLVS YAREDQRRPL MIILSLLSTR
PGSILLTGYA TPLDQLDIKS RTAILQSWCT QYMGALCTLR NTLTAVGKMI HIKSSRLFPT
ITGYSAIPLQ YSPGPSYEYT FLQFPESQSP AVLDFDVVIV GSGLGGGVSA KNLAEAGFSV
LVVDKAYHYP STQLPMTEAQ GMIHLFENGG VIPSEDSSVN VLTGSNFGGG GTVNWSAALQ
PQGFVRKEWA EDRHLPLFAS ATFQDALDRV CDRMGVTDKH IRHNHGNRVL LEGARRMGHT
AKAVPQNTGG KEHYCGHCIM GCASCEKQGP NVCWLPDAAC AGAQFIEGLS VEKVLMNGKK
AVGVKGLWTS RAGVKREIIV KSKRVIVSAG SIYSPHLLMN SGIKNNQIGR HLYLHPVNFI
SAFFKEEVRA WEGGILTTVC SSFENLDGHG HGVKLEATCM LPSLSVSMLN WNSGIDWKTN
AAKYAHMNSY ISLTRDRDPG RVLHGPKIEY TPSAFDRRHI LRGLIEMSRM LLVAGAREIH
INVPGIRPFI VDETGGGAMC EIVDPRFVAW IAHVEAVGNS PPNATFACAH QMGSNRMSAK
KADGVVDQEG RVWGTKGLYV ADASVFPSAS GVNPMVTNLA ISDVTSRGIA AGLKKETGTK
L
//
