ID A0A094AVH6_9PEZI Unreviewed; 1386 AA.
AC A0A094AVH6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Dicer-like protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=V494_07693 {ECO:0000313|EMBL:KFY33349.1};
OS Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY33349.1, ECO:0000313|Proteomes:UP000029288};
RN [1] {ECO:0000313|EMBL:KFY33349.1, ECO:0000313|Proteomes:UP000029288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY33349.1}.
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DR EMBL; JPJW01002363; KFY33349.1; -; Genomic_DNA.
DR STRING; 1420907.A0A094AVH6; -.
DR HOGENOM; CLU_000907_4_6_1; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000029288; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029288};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00657}.
FT DOMAIN 41..221
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 378..554
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 575..669
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 931..1063
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1108..1294
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1325..1386
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 1386 AA; 155500 MW; 170E2D3ADD92D3F7 CRC64;
MTSKEPTHVV LEDAPANFTG GELAKPTAIP SEQSRLYQLE MLEASMARNT IVVMDTGSGK
THIAVMRIKA ELERCPQHKR VWFLAPTVTL CEQQCATLRT NIPYVQTRLL VGSDNVDRWS
EQRIWDTVLE NIRIVVSTHG VLADALSHGF VQIEELALLV FDEAHHCARE HPANKIMKNY
YHPLLERKGP HAVPHILGLT ASPVIRSKPS DLQIIEHNLN ALCRTPRIHR GELLEHVHPP
TFVRLAYLSS PSEYGNYTSS ALVSLLAMYS NSINSSMPQA YDDDLVKKQT KTYRELKSFC
TKASHIYDEL GQWAADYYIQ TSIEIWSAAE MNRRADIFSD NGNRNVLLEQ LLHRIRSDNT
ASDSTHPDDT NTTRKVRQLV RFLTSYQEGD LHGIIFVEQR ATVAVLHQLL SLHPMTKGMI
RSGTFIGTSN FSSRKSSLGD WLSPLEQMDT LDCFRKKDKN FIIATSVLEE GIDISACNIV
ICFNRPPNLK SFIQRRGRAR KNRSIFVLLV ASEDRSLGPQ EWGVMENQMR EEYQKDASKR
QKLQQLEDEE EHVEGYSNAR FEIKSTGALL TLATAVAHIH HFCATLPPQP YVDLLPKFYF
RESPYGLVTG IVTLPNCVDA SVRTAASCRE WKSERMAKKD AAFQAYVALH KKGLVNDNLL
PLLLEKDPEA IADIETRAAV EEVSQIYDPW VRVAKSWTEA GQSLRKRLIS ISRPGHSTLH
LVIVVPQELP ALETFTVYWD NQTTYSVSIC ETTQTSTADT ASLFTMRQVT STIFQAVHFN
RMPAESNDFL ALFVPNIEEG LLQSWLEESA GNFPATELLN AEHNSSYGLI RDLARYASPH
IFKEATADGT IKVVRLPKRR DFLHRSVATK QDDAGDLDCS EKPDLFLPIE SSTIDRLPMD
YVECSLLIPS ILHRLWRKAL VLELHSTVFE NQGFLNLDYL ITATNAPSAN EDSNYQRLEF
IGDSVLKYLV CLNLYANNPS WPEGYLSRAK DQDVSNSRLS RAALTVGLDR YIVTKTFTAR
KWSPPYIRDI LEAESSPRKR VLSTKVLADV VEALIGGAFL DRGFEAAANC ISRFLPKRPI
ASPLRIFARG TNAEERVFAP TSLASGHLSD VERLIGYQFK NRGYLLEAIT HPSCEHDAHT
SSYQRLEFLG DATLDMIVVS FMVDNAPHLS HGVMHLTKTA VVNAGFLAYL CLDASLEQHV
TDVSLGPDFN LDDLMEVRSS KLVHLCQLMR YQPPEINTAM SSCLERYYKL KPAIASAIKN
GNEYPWVLLA SLAPAKFLSD IVESIIGAVL IDAGGDLSAC TKVAEHLGLI DYLRRILDDD
IDILHPKNKL GEMSLDRTVK YKPGKEGEGY TCTVEVGGAT IVTVSNGISQ EEAMTRAAYM
ATEILR
//
