ID A0A094AWW1_9PEZI Unreviewed; 893 AA.
AC A0A094AWW1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=V491_00822 {ECO:0000313|EMBL:KFY27625.1};
OS Pseudogymnoascus sp. VKM F-3775.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420901 {ECO:0000313|EMBL:KFY27625.1, ECO:0000313|Proteomes:UP000029338};
RN [1] {ECO:0000313|EMBL:KFY27625.1, ECO:0000313|Proteomes:UP000029338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-3775 {ECO:0000313|EMBL:KFY27625.1,
RC ECO:0000313|Proteomes:UP000029338};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY27625.1}.
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DR EMBL; JPJT01000409; KFY27625.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094AWW1; -.
DR HOGENOM; CLU_323683_0_0_1; -.
DR Proteomes; UP000029338; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR CDD; cd11063; CYP52; 1.
DR CDD; cd08249; enoyl_reductase_like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002974; Cyt_P450_E_CYP52_ascomycetes.
DR InterPro; IPR047146; Cyt_P450_E_CYP52_fungi.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR24287; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR PANTHER; PTHR24287:SF1; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR01239; EP450IICYP52.
DR PRINTS; PR00385; P450.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000029338}.
FT DOMAIN 19..341
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 893 AA; 97731 MW; 77F227DA8472EC2C CRC64;
MPGIIVSNGI PASQTAIIAN ETGEFIVAHD VPVMDLEPGT IIIKTAAVAL NPVDTKMIGD
FSTPGAILGN DCAGTIVAID PQVKAPLKIG DRVCGSADGM NRLRPSGGAF AEYVSCLGDL
VMKIPDDMSF EEAAPIGTAV ASAVLSVFYS AKVPGTLAKP TKAPQWVLVN GGSSSTGTMA
LQLIKLAGFR PIATCSPKNF ALAKSYGAEK VFDYRSATCA QDIREYTKNT LEFIIDCITV
EATMKLCYQA MGRAGGNYTA LEPPPEAQHT RKAIKHDWIL ATATTGRSCS WPEPYGRPGD
PLIRAFAEDF AVQTQVVFSE GKLKPHPARV LKVCSMGRGV VDREDRDSEL PSTEARAVGH
NIGINSTDYS TRGQAPNLNI LTDLYTPMPP NSAWPAGDIR AARAAQANMK ALAPEVKRWT
CFRQALRSLL PFSLEAKYKV LRFKGDFLED WVTQRFRQHG CWTYANDSRL DPSIFTAEPA
LIQAVLATHF SDWGLGASRA NAVGPLLGPG VFTSDGPIWQ HSRAVLRPQF ARDLISDLKH
TQRHVQQLFK AMPLGDDGWT QTTDLLPLIL RFTLDVSTQY FVGESMESQS KDNSVLERAF
KDANAGVQLR LKVGPFVRLA STKSFREACR TWAEYGTHFV EHAARLRDTS GSSPEEEKER
AKYSFLRGLA ASTDNNTTLM RDLTIQLLFA GEDTSASLLS FTLRCLAHHA GSYAHLRAEV
IAKFGTKSTP AAPITFTSLK ECEHLQNVLK ETLRLYPPIP FNTREALKDT VLPVGGGKDG
KSPCVVAKGT VVKYSVYVMQ RRMDLWGSDA TQWKPDRWVG RRAGWEYLPF NGGPRICMGQ
QFALTEAAYA LVRICQNYDS IECTMPEDEI STRFATALFP KLGVPIRMHW ASA
//
