ID A0A094B2F0_9PEZI Unreviewed; 1160 AA.
AC A0A094B2F0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V494_07339 {ECO:0000313|EMBL:KFY33793.1};
OS Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY33793.1, ECO:0000313|Proteomes:UP000029288};
RN [1] {ECO:0000313|EMBL:KFY33793.1, ECO:0000313|Proteomes:UP000029288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY33793.1}.
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DR EMBL; JPJW01002321; KFY33793.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094B2F0; -.
DR STRING; 1420907.A0A094B2F0; -.
DR HOGENOM; CLU_003639_0_2_1; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000029288; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029288}.
FT DOMAIN 649..709
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 711..775
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 782..856
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 130426 MW; 78EA4E9AD19369B2 CRC64;
MPPFLPRKRL RSDSPNPEQL EPGPESAKSK RSRTGNESRA QTKKTGGKSN AAIAPPRKRT
LFDDLDTGTR HSSPRKPSEL LRSLGGGGED DEEEETDSED FAFEDVVARK EDEDDDDVEF
EDVPQAGPPN TNRPSISVAP AEQEDLDLTL TKETRISLVN PHNKKQGPSK IERGIRVATH
QMHVQFLMWH NSVRNRWCCD KELQEVLTGE LMKRTSFEKD LKRWKRDSGL GGNETEENER
PKRKGKPKED NAKKGKVERG KGKERSQADW SSSAQRAEVG SVNMSHGDPL FSLLNRLSSY
WKKRFTITAP GLKKIGYMSL PRIDEEIKSN RTDYDFERHG ERIESKDSFK ELAKEHEGSR
DVGAQLFTAL LRGLGLEARM VVSLQPVGFG WSKNEEAVER KEKKIVLTEP DFQSSDESDD
ESSTPTFKEK APIKPKQSAP RSKARTTPQI SGNSTRRKGT KDLPIDLSET DQNHDDGEAG
GMVVDASPSR RQRKQPSKVY EKDLAPNYWI EVLSPVTNTW VPVNPFAAND PVVTNPDLLL
SFEPRGAKAE KAKQVMAYII GFSSDGTAKD VTVRYLRRHT WPGKTKGMRM PVEKVAVYNS
NGKIKRHDEY DWFKTVMSGY ERREQQRTII DDQEEATDLK AVKPEKKEVK EGEETLQSYK
QSSEFVLQRH LRREEALLPT AKHVKLFTVK GKADAPPTEE KVYLRKDVVS CKSVETWHKE
GREPKVGEQP LKRVPFRAAT TNRKRELAEA ELASGGQKML QGLYSREQTD WIIPPPIKDG
IIPKNGFGNM DCYVPSMVPE GAVHIPLRGT TRICRKLGID FAEAVTGFEF GARMAIPIIS
GVIVAEENEE MVIEHWREYE AERLRKEDDK RTKAALGMWR KFLMGMRIMK RVREEYGEHG
GENPDVLNPW TNKHTMGSVR SNVEEDMSRQ QMEQADEDLA GGFFPEGHEE EEVPQSFFPT
RHEDSEDDSG GFAIEHEEAD NIPSRNISNA YPTPLSIQHN KTGKMPIDAS DGEKSSSESK
PAASVASTMK GTTMSTARPP TMSNRRGANS MRDHDSDTEG QPTPNQRSSG RHSLRGGVVG
KRMPPSDNED IATPDLENDC AARVVDIPQA KTPASRKKGK STALPAESPA TRAMPRRKAT
RRSTGTKSQY FEADGEEDFE
//
