ID   A0A094B479_9PEZI        Unreviewed;      1598 AA.
AC   A0A094B479;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-NOV-2023, entry version 32.
DE   RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN   ORFNames=O988_00225 {ECO:0000313|EMBL:KFY05152.1};
OS   Pseudogymnoascus sp. VKM F-3808.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1391699 {ECO:0000313|EMBL:KFY05152.1, ECO:0000313|Proteomes:UP000029329};
RN   [1] {ECO:0000313|EMBL:KFY05152.1, ECO:0000313|Proteomes:UP000029329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-3808 {ECO:0000313|EMBL:KFY05152.1,
RC   ECO:0000313|Proteomes:UP000029329};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY05152.1}.
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DR   EMBL; JPJR01000036; KFY05152.1; -; Genomic_DNA.
DR   STRING; 1391699.A0A094B479; -.
DR   HOGENOM; CLU_003828_0_0_1; -.
DR   Proteomes; UP000029329; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029329}.
FT   DOMAIN          1275..1510
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          643..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          755..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1054..1086
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1511..1540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1552..1598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..662
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        773..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1565..1585
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1598 AA;  178336 MW;  ADC9C48549F88B9A CRC64;
     MCLGHPVISP SRRNTGLAGV FKTLTGQKTN RGLPSSPYSP SSIPIATVQL AQQLNGPDTS
     RGAIYGGPSE YEELYERLKP DNALADRLAA ADALRLAVSD YPLSGVTSIW YAAKDLISPE
     NPADARRTGF ELLTACVKHA SATDLERKEY FNTLTAQLDP DDFHLQLAAV TELAKNGKDL
     SGFHYDAMSL LTRWLRMAFE AFERARKSPR QSSKSSQPKV PLGEETNIHQ LFNLIVNVIK
     FSFNVSDDEE TGALIDEIIY IAVHATFPNE IRACVRMLDA IVTYGAIPSV KLKDFVSVLC
     SVHFMVRDIR REAWQTIGNL CRSHNGHTTI WILLDVLRHP DMNQKTQAVI REVRGSLSVL
     ERIVGKGGEG GYPPVPFGLL MEALSMSLIV DQPKVDQDIM HLILSLFGED EASLNSSILE
     EDWTKMFEIV SRCAVRALET SDGKVISKTN SSSSGSSTTD SSAHIATGIA QTFYELITRV
     EYLLLSMEAG EFIQRESCIM FFSRVSVHIP DSCAKLVIRY YIDFRFCYPS DSNWEINIKT
     LLDAFFLNRN RQTETRLLAL QAVTDVYDLV EMMEEYNDTD RKQNLVAGIL SGLADENDLT
     VVHDIVAFAV TVCDTAEQDE FEFIIKQLHQ CVNNDRLNSP LFPQAPRPSL QSSRSAGSLE
     NHVPPSAPSG IITRGIIQIF MRTMDSSATK CLRAFDEILW IVRSSSCDTE ARLSALRMLL
     RLRADWANRI FLTPFTEAEA LAALLYRTPA SLAKKQAADE AQPSRPTRTD EARGIRSTSS
     GQAYTTSSAG RSASGVSRTL QRNHQMWMTP DPEALPEQLS DKASPILVSV DAEKPDIDDS
     TDSKPIERNY LKINIWLEIV IGLLQQGCDW ELYSYILVHL PSQLANHSLF KGAIPQVKHL
     RGLLCEQIKN SSFYEPPVSS GLRKSDTAIC LLQALTMVMS YHQHFSRSEE DDLVKSLIHG
     VGAWERAAKF CIHALSICCH ELPASMKLVL GSILVKMSQI ITQSHVAVHI LEFLACLARL
     PDLYSNFRDE EYRTVFGICF RYLQYVRDQN SKAMSGRSST VSSRPTTSNL DPSSASGDGT
     KADNSATNAA NDLPQYVFTL AYHVITYWFL ALRVSDRGSH VSWITKNLVW TDDSGKQQLD
     EQAEVTLDFM RRTAYADVDE SKGDPVFSSK NHDEVLKSRW IMGQSVITVE QATRSGWAQI
     TKRQASATSH YMIHQNYEAP RAHQILSPTD GVRDPSRPNK NCFLPSNLPV QLFAPTSSSM
     QPIHLPDDDM IKRAISSLDR TSTVDGHKVG IVYIGPGQKH EKEILPNISG STDYMALLAG
     LGTLTRLQQA TFNTQGLDRN NNTDGEFTIC WRDRVTELVF HITTMMPTNL EHDPQCIGKK
     RHIGNDFVNI IFNNSGNPFN FNTFPSEFNY VNIVITPESR PSFVATRDRS SVDPNTSFYK
     VQVLSKEGFP EISPASETKI LRLKALPDFI RLLALNASVF CLVWANRHGG EYISSWRSRY
     REIQRLREKY KNASSSTTSP PGTAPQGQAP STTDSSRSVR DSFTTLRRTS VANFLTNIND
     HDRPARPPST AESENESKHG QGDDENMVAQ LDFSKWAS
//