ID A0A094B6I0_9PEZI Unreviewed; 4368 AA.
AC A0A094B6I0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=V494_04793 {ECO:0000313|EMBL:KFY37336.1};
OS Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY37336.1, ECO:0000313|Proteomes:UP000029288};
RN [1] {ECO:0000313|EMBL:KFY37336.1, ECO:0000313|Proteomes:UP000029288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY37336.1}.
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DR EMBL; JPJW01001622; KFY37336.1; -; Genomic_DNA.
DR STRING; 1420907.A0A094B6I0; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000029288; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029288}.
FT DOMAIN 1944..2082
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2236..2477
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2601..2751
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2943..3109
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3205..3260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3438..3472
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4368 AA; 494144 MW; 9FD769104FD2D4E1 CRC64;
METLVSSPAS PSANGVAGSH FSTVDPTLVV EHLARLIEAN LGATRRELES IGSLLSKSRY
PETVQRCTRF ATESQVALYV QKDIVGTEED AKQSPDGQGM YYCILANSQT GTNDDAGGFA
YTLTGDPTLS PLTITSLIVT KRSPAIDPSI PVALQIHSIV LPGAAAQTTT TGGSGPTIEV
LYNLIHNGLG PFFDAYIKNQ AAANGNSGRT EVDSKTGIQV TKKRIADLDL SLRHLQENVE
IPELSLPLHP LVQNATEEAA ARGAKPTVDY ISESILQDST FLNSLQATVN NWIKSIQTIT
KMTRDAKTGT ANQEIDFWLS KESALESIEA QLRSDGVQLT LEILRHAKRF QATVSFTADT
GLKEATEIVQ KYNQLMRDFP LDDLNSATSL SKVVEAIGLI FNHLNKKLRI CPYPVPRTLS
LVEAISADLD TKLHSLLHGR SLMHLDYRDF KVLMTTADSI FAAWDESIKE FTNVAREVTR
RRNDKFIPIK INSRHAALQQ RLKYVNTFRD NHEQLQRTIV NVLGPKSNGG GIDGGSANGV
VLIEEMGDVD AVEEVQQAFA ALKNVDLLDT SPEGTQFWAQ QETAYNERTA RVENSIIARL
RDRLATANSA NEKFRVFSKF NALFVRPKIR SAIAEYQTVL INNVKTDITA LHERFKQQYG
HSEAHAMAQL RDLPPVAGAI IWARQIERQL DGYMEKVENV LGHDWALHAE GQKLQTESNM
FRKKLDTRPI FEAWLHDVQR RQINITGLLF VINKNRSAGN ALELVVNFNP QVIALFKETR
NLVWQGYQVP HAINNISKEA KRVYPYAVSL MESVRTLAQT NRQISEMSDV STLLSGYQND
VQALIVKGLP LKWESFIHSY DVHIKQTYLA NGTMDHGNRN ESKHVQFVRE FGATVSLLQN
KTEILASINT TVQKALTDIE TCPYNEATFQ ERLETIQMAV DQLNLENFVN LDHWVHGMNQ
RIEDTLLGRL HQAIKTWIEA FQDVQSETVD SDSRRRLTTG PNDALISSVP VIRQLVHEIT
MRNQVIYLEP PLEYARANWV SELHGWLGVV CNLRKIKASR YQMSIAASNE AEARFTDLPR
NCAESLLEVY TTIENQLLEI SRYVDKWLQF QSLWDLQSEQ VYEILGDQLS KWLQLLREIR
KTRSTFDTTE VSRSFGHVTI DYDQVQTKVN AKYDQWQHEI LTKFAGRLGT RVREVHSEIE
KARKDLEVQS LEASSTAQAV QFITIVQACK RKVKTWGPEI EIFRQGHTTL VRERYQFPAD
WRSNEQVDSE WDALNELLNR KSKTVQDQTD ALRAKIVAED RLVGDKIAEI IVQWNEEKPV
SGTIAPDVAS STLTSFESRI TKLHEESLMV SRAKEALDIP GSPDAALAAI LEEVQDFKGV
WAALSTIWKS LNDLRDTLWN SVQPRKLRTS IDGLIKMTKD MPSRMRQYAA FEHIQNILRK
LLKANSLLAE MKSEAVRDRH WNKIYKSLRP GKRYSPISMT LGDVWDLNLA ASEVVIRDII
AQAQGEMALE EFLKQVREIW TNYSLDLVAY QNKCKLIRGW DDLFAKCSEN LNSLQAMRHS
PYYKEFEEEA ASWEDKLNRV HVLFDVWIDV QRQWVYLEGV FTGNADIKHL LPVESNRFQN
INTEFFSVMK KVYKVPFVLD VLNIPEVQKS LERLADLLNK IQKALGEYLE RERVSFPRFY
FVGDEDLLEI IGNSNDTLRI AKHFKKMFAG LSGLIMDQDA IISGFTSKEG EEVRLKKEIS
LVKTPKINDW LALLESSMKS TLAELLAEAY SEFHSLFTAE DVDSTLLNDY IKKYPAQIVV
LATQAVWTNA VEASLQAGGS TLQTLYEQEV KVLRLLATTV LGDLDPIERK KCEHLITECV
HQRDVIEKLV RLNATTPTHY MWLLQMRYVY QPEGEFLNRI SINMANAKLS YGFEYLGVAE
RLVRTPLTDR CFLTLTQALS QRLGGSPYGP AGTGKTESVK ALGVQLGRFT LVFCCDDTFD
FQAMGRIFLG ICQVGAWGCF DEFNRLEERI LSAVSQQVQN IQLGLKQGVE DEKSQIELVG
RQLRVNANTG IFITMNPGYA GRSNLPDNLK KLFRSVAMSK PDKELIAEVM LYSQGFNQAK
QLSKQTVPFF DRCGAKLSKQ AHYDFGLRAL KSVLVSSGGL KRARLTVSGG DLGPEEEVEP
QIIVQSIRET IAPKLIKSDV EIMRAIEEES FPGVQYIPAS LDELQAAMRS IAGERNLVVN
DTWMTKILQL FQIQTIHHGV MMVGNSGSGK TAAWKVLLQA LQQVEGVEGV CHVIDSKVMS
KEALYGNLDS TTREWTDGLF TSILRKIVDN LRGEETKRHW IVFDGDVDPE WVENLNSVLD
DNKLLTLPNG ERLNLPSNVR IMFEVETLKY ATLATVSRCG MVWFSEDTVS PTMMVDNYLG
KLRKVALEDL DEDSVATGQT TAKALAIQEE VSNLLQSYLK TEDFLLTALE HAENFNHIME
FTVARVLNTL FSLLNKTVRD IVEYNAQHVD FPLDSDQIES FVSKKLLLAL VWSLTGDCPL
GDRKVFGDYV ATLSTFGSPL LEGNSSLIDF DVTLPQAQWV SWQNQVPTIE VNTHSITQTD
VVIPTLDTVR HEDVLYSWLA EHKPLLLCGP PGSGKTMTLF SALRKLPNME VVGLNFSSAT
TPDLLIKTFE QYCEYKKTLN GVILSPTQIG RWLVLFCDEI NLPSPDKYGT QRAISFLRQL
VEQNGFWRTS DKTWVTLDRI QFVGACNPPT DAGRTPMGAR FLRHAPLIMV DYPGQLSLKQ
IYGTFTSAVL KIVPSLRGYS DALTNAMVQF YIESQERFTP KIQPHYVYSP RELTRWVRGI
YEAIRPLDTL SVEGLVRIWA HEALRLFQDR LVSEDERKWT DDAVRRNALE FFPMMDEAKA
LAGPILYSNW LSKNYVPVDR EQLREFVKAR LKTFCEEEVD VPLILFNDVL EHVLRIDRVF
RQPQGHLILI GVSGSGKTTL SRFVAWMNGL KVFQIKVHGK YSAEDFDDDL RDVLRRSGCK
GEKICFIMDE SNVLDSGFLE RMNTLLANAE VPGLFEGDEL ASLMTACKEG AQRQGLLLDS
QEELYKWFTQ QIIKNLHVVF TMNPPEDGLS SKAATSPALF NRCVLNWFGD WSDQALFQVG
SELTHSVDLD RPNYTPSDSI PVAYRDLSLP ASHRDAVVNA MVYIHYSLQR FNIKLQKQQS
RVTFLTPRHF LDFVAQYVKL YNEKREDLED QQRHLNVGLE KLRDTVDKVR DLRISLAEKT
EQLERKDAEA NEKLQRMIAD QRLAEQRKTT SLEIQSALEK QEVTVAERRE LVLNDLANAE
PAVIEAQKSV SNIKKQHLTE VRSMSNPPRA VKLALDSVCT LLGHRIDSWK TVQGIIRRDD
FIASIVNYDN EKQMTKNLRV KMRNDFLSKE DFTYEKVSHA SKACGPLVQW VEAQVNYSEI
LDRVGPLREE VGLLEEKALE TKAEAQAVEN TITALEQSIA RYKTEYAALI SETQAIKSEM
SRVQFKVDRS VRLLDSLSSE RTRWEDASKS FETQISTLVG DVLVAAAFLA YSGLYDQQFR
KNMMDDWLGQ LQMSGIDFKQ HNPITEYLSS ADERLSWQEN SLPVDDLCTE NAIILKRFNR
YPLIIDPSGR VTEFLQKECK DRRLTVTSFL DDSFTKQLES SLRFGNPILI QDAEHLDPIL
NHVLNKEYQK TGGRVLIQLG KQEIDFSPAF KIYLSTRDPS ATFAPDVCSR TTFVNFTVTQ
SSLQTQSLNE VLKSERPDVD ERRSNLIKLQ GEFKVHLRQL EKRLLQALNE SRGNILDDDN
VIETLETLKK EAAEISKKMS NTEGVMAEVD AITLQYNIIA RSCSAVFAVL EQLHYLNHFY
QFSLQYFLDI FNSVLHDNPR LATETDHNVR RDIIIEDLFV TTYQRTSLGL LQKDRITFAM
LLAQASPFKM EKNLIDLILD DGIDGTDLST ETDRKEEVFA RAARVPALKG KLDNIPPADL
ERFLCEEMGE NFIPKIWDDN TSEIDKELLS LLVVKIFRLD RFVPSAERFV TAVFGSRIFD
MTEDLRQTVE QVSASRPIAL CSSPGFDASY KVDSLVERVK ASCTNIAMGS NEGLSTADKA
ISNAAATGNW VLIKNVHLAP TWLQSLEKRM DSLKPHPDFR LFLSMESSPK IPVNLLRASR
VLMYEQPAGV RANMKDSLSS VSTRAIKTPV ERTRLYLLLS FLHAVVQERL RYAPNLGWKG
FWEFNDSDYE CSAYVIDTWV ESISAGRSNV APQNLPWDML RTLITETYGG KIDDEGDFAR
LTQLVESIMT PAAYEIGHKL VESTPGLTVA TDGSDGSLVV PSGTGLKEYM EWVNKLPERE
PPTYLGLPAN AEKLLLVGLG RSMIGNLGKI TEILDEGEQL MAEAAVAA
//
