ID A0A094BUN5_9PEZI Unreviewed; 3650 AA.
AC A0A094BUN5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFY14087.1};
GN ORFNames=V492_02867 {ECO:0000313|EMBL:KFY14087.1};
OS Pseudogymnoascus sp. VKM F-4246.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420902 {ECO:0000313|EMBL:KFY14087.1, ECO:0000313|Proteomes:UP000029299};
RN [1] {ECO:0000313|EMBL:KFY14087.1, ECO:0000313|Proteomes:UP000029299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4246 {ECO:0000313|EMBL:KFY14087.1,
RC ECO:0000313|Proteomes:UP000029299};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY14087.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJU01000874; KFY14087.1; -; Genomic_DNA.
DR STRING; 1420902.A0A094BUN5; -.
DR HOGENOM; CLU_000022_31_2_1; -.
DR Proteomes; UP000029299; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF22; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029299};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..431
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2515..2592
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 462..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2938
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 3650 AA; 401251 MW; 2D716BBDF2AE6FDE CRC64;
MSDLEPIAII GIGCRLPGDV GNAEDFWRLL SEGGSGWSVV PKDRWNVDSF YHPDGTSIQS
YNAKSGYFMS QDVTDFDSRF FGFAHNEANV TDPQQRILLE TTFEALENSG VSMESVKGSD
TAVYAALFAR DYDRIGYKNL EGLSQFHIPG TGEAIIANRV SHFFDLRGVS MTIDTGCSGS
LVALHEACTA LRTRQSRMAI VGGTEVLLHP DQNVIMSSGG MLNPDGKCYT FDSRGSGYGR
GEGVAVVIVK RLKDALADGD TVHAIIRNSG ANQDGKTNGV TLPNPDAQEA LIRRVYSDVH
LDPAETPYVE AHGTGTKAGD AAEVQSLGNV FTEKPRSRNL YVGSVKTNIG HTEATSGLAG
LIKSVLILKH QQIPPNLNFI KPKPGLNLDE RQISVPLDLV PLLPEGSKGA HRVSLNSFGY
GGTNCHVILE SLDQYLSDHS GYLTNGSING ATNGVVNGAD GHSATNPNEN NSIRLTNGTN
GVNGSYGSNG VEEKSTASAE SMPFIFPLSA TSEAALDEIP AQIQKWLLGP DASTSGLSDL
SYTLACRRSL FKWRKAFVAS NVTELKTALG EGKISKTRSA PSAKVAFIFT GQGAQWAGMG
VELIGSSQVF KSSIESSSQL LRSLGCEWDL TQELSKSEAE ESRINESELA QPVTTIIQMA
LVDLLAHYDV KPNFVAGHSS GEIAAAYAAG ALTQEAAVQA SYLRGLQSAI AKKLNELPGS
MLATGYGEHV ALQAIKAANI DSEMGRVVVA CVNSPTSTTL SGDEPAVHYI SEMLRSGGVF
RRKLKVETAY HSHHMEKVAS SYLKSLEGLS STEIKSNVEF YSSVTGQTKN SDFGPAYWAE
NLVSQVRFND AMTALLEGMA ATAPPDAANI LIEIGPHSAL QGPINQILSS IPGFKSAYIA
PLSRGKNSVS SFSAATARLF ELGTKVNFEK LFTKPQRVID NLLPYPWDHR VKHWAESRIS
RDHRLRSFPY HDLLGVYDVM SPIEEPRWRH HLSIQRLPWL KDHVVDGMVI FPGSGYSTMI
TEAMKQLVQL KKPDSDTKIA NTIIRNVRIA RPIILPVEST DGPGDDIEVQ LILSPSKISD
ANPWYSIRIL SLQPDGTWAE HVSGTVRAEL VSASVTGKER KATVDEAFEA FKRIQSRAQE
KLNMETFYDE RRAAGNDWGP NFALLYEAHI GPWVGFSKLR IPDMAQCMPA GYFQPHLIHP
TTLDASNHMV PAVFHREIKN APLMPISTEE VLFTNNLSSK PGDEMIVAME LKAEGKSQAR
GNVWVFQNDS VTGEVTFVSS MRGLVMRAVG EGASTDEYKP FQRKHNYQMY WNDDPDHLGK
DSFARLVEPH VRKNSELVEQ LSTIEKATAI YLNRVKDMPV VKNPETSPLP HLRSFSRWIS
DYVNSDACRK ICKSLSASEQ AEVLDRSDSS DIEGEMLGRV GRNLADILSN TADPLELLVA
DDLFERFHNQ GPLTPLYQQL VQYAGLLVNK NAQMNVLEVG AGTGSATLPL FMSMGDDASD
LVKKYTYTDI SSGFFETAKE RLDKWKSIIE YKTLDVSRDP MDQGYKANAY DLVVASNVFH
ATKSIRETLT NVRKLLKPSG ILLFVEINNS PAGASRSLGT IFGTLPGWWD FVDAREGSPL
LTPDQWHEQL LQSSFGGIEY SSQDCDGPLA RASLIVSKAI EEPKPTDTPL LIGSVAVIYN
PVSPMGQLAS AALTSAFQQK GFTSSINYSW EALAEVDAEA CESTMYVVLD SANSSILKHP
TQEMFDRYQN LLVNCRNLIW ISFQEEGGLK EGSIKGLAGG LARVVRRENG GVKLITIDVR
NVLSTKDDVS RFVHKIQDVS LQLLQPGISN RAIVDEEFAI DGDKILIPRA YADKKFNNWT
DLVNGRSNLS PQPFKNLALP LRMEVGTPGL LSSIHFIHDT DASSPLGTEQ IQIDSKAFGI
NFRDILCALG QLQNGTFMGE CAGIVTAVGS GEFVQSTYKV GDRVVGMHAQ PFASYSRLNG
YDAHVLPDNM SFADAASMQV VFTTVYYSFV NVARLEAGQS VLVHYGSGGV GQAAIQLARH
FGAEVFVTVG SEKKKKFILD YFNVPESHVL SSRASPRDLK RHLLRLTQYK GVNVVLNSAS
GEMLAESWDC VASFGFHIEL GKTDIDKNTH ISMAPFKRNV TFSSVDLVTI AKERPKMFYD
VLDKTIALFA KGVLKPVYPL NKFPIDQVES AFRLISERKH IGKVVLECEN EEKVQAVLPE
PAPTKLQPEG TYIIAGGLGA IGRMLVTHLA SRHAGHIITL SRGDLADEKR LPWQAEIVKL
GAKLHVLKCD VTDESSVQRV AEYCRQSLPP VRGIFHAGMV LRDRPLAIMT RDEWNAVLGP
KVRGTFNLDQ AFSSANLEFF VTLSSIATTF GNPGQGNYSA ANAFQDYFAT HHDRTYATRY
VSVDLPVVDE TQALAQIELG TRSFILQVSM LFDVRELMQL MDYAMNRSVE LDRPFLHAIM
GFDRKSMSQG TGDDLFSALF QTIPQMQTSS SQDSNGADAK QDIESLLTAV SSFDEAVEVI
METTMEKFVK FLNFEADDVR PDQPLSSYGL DSLVSIELKN WMVRAFKVTL QVSELTSSRN
IAHLAELLAT RSKILPAGLS KQTQDHKPAK DEAENKANFQ EEQALLAQPD DAEIETLPCC
PLPTKKARQP VPNLVLGLQK HLENSSHFAH SEDEVESLRS AMKEFLAPGS VGEQVYKEIQ
EDACDPKVGN WISKYLSEGY YMPMRQALQY CSFMVMNHPV PVSHTQADRA ALLAETAFQF
KQNIDNGTVE PMYILETPVC QAQLKWMFNT YRHPQIGNDE IIKTAGDYCV VFRRGRLFQV
PLQTGDDPVS FDMLRATMAA ILDHVQDEGT WAGILTSDNR DSWANVRTQL LAVSPGNAHY
FQVIEEAAFA MNLDDSSPTN FTEFAKQCKM GSGFNRWHDK PMQFIVTANG QSGLLVEHSY
LDGTTPAALY DRMHDAIAAY KPTGQAPPQV PSPEEIPLVL PSNLDKHISF LREQWLSNNA
LRDFISYELP TLSGHILGQS KVPIKSGYDV MCQLAFFLYN GRRVVPNWQP VMLSQFHDGR
HDMVQMASPK VRAFCEAVVA TGEDEVPILQ KRNLMIEAAR DVSRRLSEAK DGKGFFRLFV
TIEQRLPKDQ PKPRVFDDAL QKRTWEFPIS NINHNSVESV TTPLDPHALR IRYTIHDDHT
LMSLNCPTGA ADKLIEAVNE AATIIRELTK GWAQARLYYR VLAQMLIKIG DKNTSEEDSA
VLVAGYTSTV AGCGFVAAYY ADTLPNHPEL RPLAAFDISP SRATAFSKRF NIPVAASYQA
ILENPDIDLV VNLTPPASHV EVSRAALLAS KHVYSEKPLS LEPAGAKELI ALAAKQNRLL
AVAPSNFLGG SLQTLARLVR ENVAGTPRLV YAEIDDGPIH QLPYSTWKSG AGAPWPAETE
FRVGCIWEHA AYEVGFLTSV FGPAASVTSF SHTLVTDKKM EIAPQDLGPD FSVAIILFRS
GVVARLTIGT VARRNRSMTI TGDKGILHVP EVWDCEAPVQ FTLSRGSTAN PASPLLLVMQ
PTTSERVAYS PGMPMPERGI QVDTPADGPR QYPKAYRMDM CLGIAELAAA IREKRRPRMA
ADHAFHVYEI LQALDDSVAA PGHREIKSDF APIDPMPPLQ TVASDCTISW
//
