ID   A0A094BUX6_9PEZI        Unreviewed;       499 AA.
AC   A0A094BUX6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=V494_00943 {ECO:0000313|EMBL:KFY45479.1};
OS   Pseudogymnoascus sp. VKM F-4513 (FW-928).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420907 {ECO:0000313|EMBL:KFY45479.1, ECO:0000313|Proteomes:UP000029288};
RN   [1] {ECO:0000313|EMBL:KFY45479.1, ECO:0000313|Proteomes:UP000029288}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4513 (FW-928) {ECO:0000313|Proteomes:UP000029288};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY45479.1}.
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DR   EMBL; JPJW01000289; KFY45479.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094BUX6; -.
DR   STRING; 1420907.A0A094BUX6; -.
DR   HOGENOM; CLU_009834_22_0_1; -.
DR   OrthoDB; 3639304at2759; -.
DR   Proteomes; UP000029288; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029288}.
FT   DOMAIN          67..409
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   499 AA;  55716 MW;  3DDE1A3D12341F81 CRC64;
     MISRSLYRRA GAAVSWNSRA TMPLTSKIQN PAFKAQMATK ATDGAAIKEL PGDEAEDVLF
     DTLYGLRTIE LNRPKKLNSL NGSMVRKIVP RMQEWTKSDM ANIILLKGAG EKAMCAGGDV
     AELAKWNSEG PKGQQRSTDY FGLEYKLDHM IATYKKPLVA LMDGITMGGG VGLSIHTPLR
     IATERTVFAM PETTIGFFPD VGASFFLPKM NGSVGTYLAL TSDRLKGANV FYAGIATHYI
     HSTSLPSLEA RLAELRFNDY DSLDTRLQLI DSTIEEFTTG LPHDEPIHIA GAMREAIDRC
     FSPDSVPEII AALEAETGET QEWAQKTLKT LQQRSPTSVY VTLRQMRLGK DWSIKETFQR
     EHQIAAKFMR HPDFTEGVSA LLIRKPEPGQ PRQPPKWQPA SLDDIKASDN VAEPFFEVEG
     EKKLDLLSEE DYTRYPHAKY SLPTESQVAR HVRSELKSRK SIVKDFVQMR SGKQGIKEVV
     EEILSRKTTV QDGKAVWID
//