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Database: UniProt
Entry: A0A094C5R8_9PEZI
LinkDB: A0A094C5R8_9PEZI
Original site: A0A094C5R8_9PEZI 
ID   A0A094C5R8_9PEZI        Unreviewed;      1480 AA.
AC   A0A094C5R8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   03-JUL-2019, entry version 29.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=V496_10138 {ECO:0000313|EMBL:KFY49269.1};
OS   Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY49269.1, ECO:0000313|Proteomes:UP000029302};
RN   [1] {ECO:0000313|EMBL:KFY49269.1, ECO:0000313|Proteomes:UP000029302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A.,
RA   Gerasimov E.S., Kochkina G.A., Ivanushkina N.E., Vasilenko O.V.,
RA   Kondrashov A.S., Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence
RT   of horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFY49269.1}.
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DR   EMBL; JPJY01001952; KFY49269.1; -; Genomic_DNA.
DR   EnsemblFungi; KFY49269; KFY49269; V496_10138.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000029302; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029302};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      129    471       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      535    965       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1004   1078       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     62       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A094C5R8}.
FT   COILED       68     88       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     25     39       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A094C5R8}.
FT   COMPBIAS     41     62       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A094C5R8}.
SQ   SEQUENCE   1480 AA;  167187 MW;  32697FC4172B64D0 CRC64;
     MVGTLLPQKR VFGEASSARR NIDSSPASMK KRKLEGADTP ISRLKSSQNG PKGKPGSSQP
     SHFESEVLEK LTQDMTGLKN KNSEKDQQWD RPALTDFNAE TDNLIFQQIE AEEGTLHGGK
     ATVKLFGVTE TGHSVMLHVT DFLHYLYVAA PVAFVRTDCE NFKVFLESQV AQHQPAIHSV
     QIVMRENLYG FQGNQQSPYL KITVTDPKFI NRVRTTIEGG NANWKGMWKG ADGGVLTFDS
     IQYVLRFMVD TKMAGMSWVE APAASYKMIN ANERQSNCQI EAEIGYRDLI AHKPEGEWSK
     MAPLRILSFD IECAGRKGIF PEANHDPVIQ IANVVTRYGE KKPFVRNVFC LDTTSLIVNT
     QIFEFQREEK MLMAWRDFLE KVDPDIIIGY NISNFDFPYL LDRAKHLKVG GFDYWSRLHS
     IKSVAKESNF SSKQMGNRDT KATNTNGRLQ LDLLQLVQRD HQLRSYTLNS VSAQFLGEQK
     EDVHHTMITE LFNGTPESRR RLAVYCLKDA YLPQRLLDKL SCLENYTEMA RVTGVPFNFL
     LSRGQQVKFV SQLFRKALEQ KLVIPNQRTE ASGEQYEGAT VIEPTRGYYD VPIATLDFAS
     LYPSIIQAHN LCYTTLLNKA GVEKLGLKKD EDYIVTPNGD MFCTAKQRKG LLAQILDELL
     TARKQAKREL AVETDPFKKA VLNGRQLALK ISANSVYGLT GATVGKLPCL EIAGSTTSYG
     RQMIEKTKAE VEAKYTIANG YAHDAQVIYG DTDSVMVKFG TKDLAESMKL GEEAASYVSS
     KFVKPIKLEF EKVYFPYLLI NKKRYAGLYW TNPNKYDKMD TKGIETVRRD NCRLVQTTIE
     TVLRMILIDQ DVQGAQDYVK DTISDLLQNK VDMAKLVITK ALAKADYANK QAHVELAERM
     RKRDAGSAPT LGDRVAYVII KGAAGAKNFE RSEDPLYVLE NNVPIDTKYY LDNQLAKPLG
     RIFEPMLGET RARSLLTGAH TRSVAIAAPS VGGLMKFAKK TSTCMGCKKP LVGKEESGNA
     VCKNCAPRMG ELYTKTLTKV SDLEVRFGRL WTQCQRCQES MHCEVICSSK DCPIFYMRMK
     AKKDVEDAGK ELARFDKDAA ACDLSLEPSA MPSLKKWLRN KLPYRKGTPL KPKPTIDPLP
     LLPVERPSIL TPSPSREALV SFTDSYGYFQ LLPYEIRHQI LIYAIGGRTL HIDPLYITWP
     VIKDHKFIFD SDEKPIYSPG PTWGWFSGEC HQTTLWPDGI PRRNFGEREI KTPRRLPCAG
     GCADGRNRVG GCCGVGIMGW LLACRPAYAD AIDVVFATNT IHMEKYDLLK QLPRVILPQR
     LRCIESLELS WDFRPELHVS GYKPLRVLWE DQTAKDSDLH EMCRMVLQLF PGLRRLDINL
     LFETRNIPGG AERTILGPIE DMIQALGPGR EVCIAIQQSV FYALYEEHRG LYGQKLKTEV
     YNPYATRFWK ELDLHNGLGY WICSGTPDHC RLGSTYFDNY
//
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