ID   A0A094C672_9PEZI        Unreviewed;      1102 AA.
AC   A0A094C672;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=V496_09882 {ECO:0000313|EMBL:KFY49671.1};
OS   Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY49671.1, ECO:0000313|Proteomes:UP000029302};
RN   [1] {ECO:0000313|EMBL:KFY49671.1, ECO:0000313|Proteomes:UP000029302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY49671.1}.
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DR   EMBL; JPJY01001921; KFY49671.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094C672; -.
DR   STRING; 1420909.A0A094C672; -.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000029302; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          308..380
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          885..957
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1048..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1061..1087
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  121555 MW;  236B7A0218CB1B4D CRC64;
     MTMNGSTRSK RKQHAAPLPE RPQKLHRAVN GKESVGENTP DLGSSSPIDE MEMEMEEEDD
     GRIGVIAPAD SAEWQETIEE VVRNVVSIRF CQTCAFDTDP ALTSEATGFV VDAERGYILT
     NRHVVGSGPF WGYVVFDNHE EVDAYPVYRD PVHDFGILRF DPKAIKYMPV AALELRPDLA
     KVGAEIRVVG NDAGEKLSIL SGVISRLDRN APEYGEGYSD FNTNYIQAAA AASGGSSGSP
     VVNIDGFAVA LQAGGRADGA ATDYFLPVSR PKRALECLQQ GLPITRGTIQ CQWMLKPFDE
     CRRLGLTPEW EAKIRAEFPK ETGMLVAEIV LPEGPSDTKL EEGDILLKVN GELLTAFVRL
     DDILDSNVGE RVKLLIQRGS EDIEVELGVG DLHKITPDRF ISVAGASFHD LSYQQARLYA
     VACKGVFICE ATGSFKFEGT DSGWLVQSVD HKKTPDLATF IEVMKAIPDR SRVVVTYKHL
     RDLHTLNTSI LYIDRHWSSK MRLAVRNDDT GLWDFSDLAE ALPALPPVPR SASFIQLDNP
     THPAAAELVK SFVRVACHMP VKLDGFPRNR KWGMGVVLDA EKGLVIISRA VVPYDFCDIS
     ITIADSIIVD GKVVFMHPLQ NYAIIKYDPS LVDAPVKSAK LSTEQIKQGA STFFIGFNQN
     MRIVVAQTTV TDITAVAIPA NAGAPRYRAV NLDAITVDTS LSGQCGSGVL VAEDGTVQAL
     WLTYLGERSS TTNKDSDYHL GMATPTLIPV IKQIQAGVTP ALRMLSVEFN AIQMSQARIM
     GVTEAWIKSV AAANSAHHQL FMVRKRTFER DEDAHALQEG DVVLTLNGNI VTRVSELDVM
     YDNEVLDAVI VRDCVEMRIS VPTVASHDVE TDRAVNFCGA VLHRPHLAVR QQISKLHSEV
     YVSARTRGSP AYQYGLAPTN FITAVNGIAT PDLEAFIREV VRIPDNTYFR LKCMTFDNVP
     WICTMKKNEH YFATMEWIKD PSEECGWRRV SYEHGESIKG EGKDGINEIA AESVCEDDVG
     AGDTEPVAVK ATTQVVYVVD RNMGTSAGGL GLDSYPPSNS RRRRQRLHRR AAARKNHRQR
     QRHQKRHNGA LIYPDPKPAV RP
//