ID A0A094C950_9PEZI Unreviewed; 799 AA.
AC A0A094C950;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Disintegrin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V496_09220 {ECO:0000313|EMBL:KFY50696.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY50696.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY50696.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY50696.1}.
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DR EMBL; JPJY01001808; KFY50696.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094C950; -.
DR STRING; 1420909.A0A094C950; -.
DR HOGENOM; CLU_012383_1_0_1; -.
DR OrthoDB; 2961161at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04271; ZnMc_ADAM_fungal; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR034028; ZnMc_ADAM_fungal.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF159; MIND-MELD, ISOFORM J; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13688; Reprolysin_5; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..799
FT /note="Disintegrin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001898363"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..497
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 522..614
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT ACT_SITE 435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 434
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 438
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 444
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 799 AA; 83948 MW; 682BC722BF0D3FB3 CRC64;
MRLLRCVAAA IVSAGFSHIA QAHSVKRAPL SYLSIVDEPV IHTPSHRVHA HSSFDLSFHL
HGRQQYIKLT LDPNDDVIAE GATVNYIGAD GQVREVELIE RTDHRVFKGH AWVRTHEDTQ
WTHAGWARVV IHRDGVDPLF EGAFRIDGNH HHIHPRNSYI ATKHELDPYV EDDREDIMVV
WRDSDITPDD SSRGELKRDV NTGSCLSDDL AFNLMPEHPV YSQGYSQSTI LRKGESFWGS
ISTGSIFGRD IDPASTMPGN GAGVNLLNSI GNPDGCPTSR KVALVGIATD CTYTGFFNST
SSVRSNIITQ MNSASVLYED SFNISLGIQN LTITDAACPG ASQANTPWNR DCNSGLQIQD
RLNLFSAWRG ASPDTNAYWT LLTTCGTGSA VGLAWLGQAC VNTAQASSQE GSNDTVSGAN
VVVKTDTEWL VIAHEVGHTF GAVHDCDSTT CADGKTVAAQ QCCPLSADSC PAGGKFVMNP
STSSGITNFS PCSIGNICSA IGGQSVKTHC LTSNRNVPTI TGSQCGNGIV EMGEDCDCGG
ESGCGDNPCC NPTTCKFKTE NNAVCDPSNE DCCLSTCQFA TAGTVCRAST GECDPQETCS
GTAASCPADA HKDEGSGCGA DGEGLSCASG QCTSRDKQCK TLMGPQYYQC SDDGCQLFCA
SDASQFTCDG LTQNFLDGTK CGGGGKCSNG VCKGSSVAGR IKEWVDQHKP LVIGLSAGVG
GLLLLAILSC IFSSCKRRRR ARKYVPGGAM PPGNGRGEWE GGAGVGAAGA GEGVCACADA
AGDAAARDGR AADGRAAAV
//
