ID A0A094CLB3_9PEZI Unreviewed; 3879 AA.
AC A0A094CLB3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=V497_07344 {ECO:0000313|EMBL:KFY54916.1};
OS Pseudogymnoascus sp. VKM F-4516 (FW-969).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420910 {ECO:0000313|EMBL:KFY54916.1, ECO:0000313|Proteomes:UP000029268};
RN [1] {ECO:0000313|EMBL:KFY54916.1, ECO:0000313|Proteomes:UP000029268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4516 (FW-969) {ECO:0000313|Proteomes:UP000029268};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY54916.1}.
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DR EMBL; JPJZ01001184; KFY54916.1; -; Genomic_DNA.
DR STRING; 1420910.A0A094CLB3; -.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000029268; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000029268}.
FT DOMAIN 2679..3234
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3524..3850
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3847..3879
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 161..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3240..3350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3240..3255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3256..3296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3317..3338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3879 AA; 440538 MW; FC1DF4D1BA0D7E64 CRC64;
MSTNLIDIVV QRLSNPDLDV KLRVDAATQL RDSLEHYTTA QAYPTFLKKL VPIFIQLLKG
QPVFISTNPE QKLRNCVLET LHRLPTSPPE PFEPYTVDVV NVLIGLVRVE NEDNAILCVK
TIMDIMRHQT KILQQPGNNQ VQDFLSLIQE MFDDMPAVVH EQLDNPSPSA ANAVIPSTPG
SSQNFQSPRP GSPVASVSDL GADPQQQTRP LSKGMQSFKV LAECPIIVVS IFQVYRQTVP
ANVKKFVPLI KVVLMLQAKP QEEAHAEAKA KGQIFTGVSP NIRNRAAFGE FITAQVKTMS
FLAYLLRVYS QQLQEFLQTL PGIVVRLLQD CPREKSAARK ELLVAIRHII NFNFRKIFLT
KIDELLDEKT LIGDGLTVYD TMRPLAYSML ADLIHHVRDQ LDANQIRKTV EVYTKNLMDS
FPGTSFQTMS AKLLLNMAEC IARMENKADA RHYLIMILNA IGDKFEAMNR QYPNAIKLSK
TYAQQKDEAA PDNYLADLEH PPDWDEIDIF TATPIKTSNP RDRGADPVVD NKFLFKNLMN
GLKNMFYQLK ACNIGSPIDP ANATPHWQDV SYGFSAEEVQ VIIKLFREGA YVFRYYEIEK
PAAESQYSSP VEFMANHYMT SSTKEEKDLL ETFATVFHCI DPATFHEVFH QEIPNLYNMI
FEHTALLHVP QFFLASEATS PSFAGMLLRF LMDRIDQVGT ADIKKSSILL RLFKLAFMAV
TLFSSQNEQV LLPHVLDIVT KSIELSTTAE EPMNYFLLLR SLFRSIGGGK FEHLYKQILP
LLEMLLEVLN NLLMAARKPA DRDLYVELCL TVPARLSNLL PHLSYLMRPL VVALRAGSDL
VGQGLRTLEL CVDNLTADYL DPIMAPVIEE VMTALFDHLR PNPYSHFHAH TTMRILGKLG
GRNRKFMTGA PALTFQQYSD DRASFDLKLN GSKKDRAFPV EIGIELAIRK LMEIPKGAAA
KKSDIYYKKQ ALHFVKAQTK LRIGYDSLPD EFGRLVRLQA QDFLARDSNA DFSALEVNDR
QRSVMKKDLE QEMLKRLIKA LMFSVSIQDL KEEALATLLG VCRHFTILEV GHALAEFKLK
RQPFDIKAGE GPVVIDSRVL ADAITESLSS DNILVREAAE RALREVFDST AIIFGSNAQV
GRLSFFTHLS NVFCHSCYEE EWFTKAGGSL GINLMVTKFE IGDSWISDRQ FEYVKALLYV
IKDMPQDLPA KTRIGAQETL EVLLKRVTKN SAKKDILPPA PLPPGVPRPQ AASRLPHLCQ
LFGSGLSHLN RHVRETSQKA LTTISETVGV EVWELLEPQK DNILNPIYSK PLRALPFAIQ
IGYIDAVTYC MGLKPDFVQF DDVLNRLLME SLALADAADE SLAGKPAEQR THEHIISLRV
ACIKMLTTAM GFEEFQKGPN NATRTKIVSV FFKCLYSESS QTIEAANDAL KVVLSQTTKL
PKDLLQNGLR PVLANLQDPR RLSTHGLDGL ARLLQLLTTY FKVEIGSRLL DHIKVLAEPN
ALQRISFTLI EQNDQMKIIA AVFNIFHLLP PAAEHFKERL VETVLDLEDK LRRTRYSPFR
APLYKYLNRY PNEVWMMLLG KIEEQKYGRF LAQLLEDPDS APLRSVVVNS VDMLIKNCGD
MGAENKETRY AAVINAINVM HSVCKYPGTE AWMEKKENLM WFRLVGKNLE QRLRNYSLPS
NLRLAAEQAG EQLMIIFTKF LEIHPKDLDA LFGLVDSVTC GDFKPSQQFF SYIYKNIICN
ESIDYWKSII LRSLDVYSSK TASQKTKAFL LHNIVNPIIA KDVMRTWPRT GPMKGPRLID
RAVIESIHTK IWRASLGDPS EDLTQPGIDH TRMEVLQLSA MLVKHYHAIL QDARKDIIKF
GWTYIRLEDV INKHAAYVVI GYFIAHYETP AKIVVQVYLS LLRTNQNEGR TLVTQTLELL
APVLRKRCNS APGDRNPIWA SGARRILAEE GQNVQQMTSI LHFLVKHDEL FYESRDKFVI
SIISSFRKIA QPTTASNESR RLVLQLMNLI WEWEKTRVED KATSPSRLMS ESPNAKKRKI
ESTPVGESSS PSSQKASPQK ARSSPPDRAE YQIPLVYRQK MIKYLVEFIA GLPERYPLQS
AKQREPAQFQ IPAPPSSSIE MITKSISLLK NLLQPQYWSD LDIDLFPNVT DIMLASDRTT
AALASGGTDK EKPDDKFLTN MINTLQVVRV IVNTKTDDWI QKNMSNLQRI LEKSIKSDNA
EIQDCLHSSC QNGDDGRPLK PLLKAILDAV PDDVQMEDAD ADGEAEASTS EIITFLSTTA
TEDLSSGNYN SGINILWTLA QRKPSEMDQG IISAIMRALQ TKLAKEHVAH YAAAVTQSVA
AAAQQENEPT GLMNKYDLKI QTGLMLKAID IMSMRMEVLG DYRRPFLSVL ATLVEKSQSN
ELCLKILDMV DGWVFKSEGS WPTLKEKTAV LHKMLTFENR QDQTLLIKFL ELVIRIYEDP
KITRTELTVR MEHAFLIGTR AQDVDMRNRF MAIFDKSQSP TASARLTYII TSQNWDTLAD
SYWLAQASQL LVGAVEMNKP IQLHHEDFKT IPASVLFGNY AKDTRQPNLM DDDKYDEFIA
GHRRFVRELG DVTVRDIMEP LTQLQHLDPD TAHEIWVSLF PIYWSAMAKD ERGELERGMV
SLLTKDYHSR QIDKRPNVVQ SLLEGAARSW PDCKIPPHVM KFEAKTYDAW YTALVQLENA
AIKPTTDSAL VKESNLDALV ELYAGLQEDD LFYGTWRRRC QFVETNAALS YEQNGMWDSA
QKMYEAAQIK ARTGAIPFSS GEYMLWEDHW VLCAQKLQQW DILQDFAKHE NFQDLLLECA
WRNPETWQTQ DPRDQLDAII KGVMDAPTPR RTFFQAFMSL LKFHNKTETS ADFSKVCDEA
IQLSIRKWHQ LPKRITNAHI PLLQNFQQLV ELHDASVICQ SLAQTTQANL DVKSGELKLL
LGTWRDRLPN VWDDIMAWQD LVTWRQHIFG LINTTYLALL PQQGQNANGA SFAYRGYHET
AWIINRFAHV ARKHQLPEVC ISQLSRIYTL PNIEIQEAFL KLREQAKCHY QDSNELNQGL
DVINNTNLNY FGPQQKAEFY TLKGMFLDKL SQKHEAEEAF GMALFFDIKL SKAWAEWGYY
NDRQFKETPT NYEFARNALS CYLEAAGLFK NAKSRKLLTR ILWLLSLDDA SGTLAETFDA
YKGETPVWYW ITFIPQLLTG LGHKEAAKAH SLLAKIAKSY PQALYFQLRT NREDMLAIKK
SQESKELRER NARASKQNAR QPSVGDAVKQ SGSPSQARSV TPSVRPDSSA GSRPGTANGV
VNAALNGEGS AVKPEPAEAS NNPNATTNTP NAQGQPQATP APAAVAPTKK PPWEHTEEIL
LVLKTAFPLL ALSMETMVDQ IQKHFKCPPD EDAYRLIVAL LNDGLSYVTR MPNSYALDVK
LPSATETNIT RFAETILPAH IRKSFEADFV DKKPTMHEYI QKLRRWRDKF ESKLDRRPLH
QNLEVYSTHL SEFRFGKFDE VEVPGQYLQH KDKNQDFIRI DRFLPDVDLV RAIGVCHRRL
KIRGHDGSVH PFAVQHPAAR HCRREERILQ LFRHFNATLS KRKESRRRNL NFHLPLMIPL
APHIRMVQDD PSYISLQGIF EDHCRKSGLL KDDPILFTMD KLRILAEAKT AKHPDHALNA
RMEIFSAIQD KWVPHTIALD FFKASYPAYA DFWLFRRHFS YQYAALTFMT YILFMNGRYP
HKLNIARATG NIWGSELIAS MAAGKPTFHN PEPVPFRLTP NIQTLMGPMA TEGIFTCAIM
AIARCLTEPE FDLEQQLSLF VRDEMIFWFT SSHRAGSMGE GQLRETVQVN SEIIVKRTLS
LAQAPMGMLP ANQTIIDLVA KAVNPMNLAQ ADALWMPYL
//
